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Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data.
J Parkinsons Dis. 2017; 7(1):193-202.JP

Abstract

BACKGROUND

Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson's disease (PD).

OBJECTIVE

To examine whether exercise habits were associated with changes in HRQL and mobility over two years.

METHODS

We identified a cohort of National Parkinson Foundation Quality Improvement Initiative (NPF-QII) participants with three visits. HRQL and mobility were measured with the Parkinson's Disease Questionnaire (PDQ-39) and Timed Up and Go (TUG). We compared self-reported regular exercisers (≥2.5 hours/week) with people who did not exercise 2.5 hours/week. Then we quantified changes in HRQL and mobility associated with 30-minute increases in exercise, across PD severity, using mixed effects regression models.

RESULTS

Participants with three observational study visits (n = 3408) were younger, with milder PD, than participants with fewer visits. After 2 years, consistent exercisers and people who started to exercise regularly after their baseline visit had smaller declines in HRQL and mobility than non-exercisers (p < 0.05). Non-exercisers worsened by 1.37 points on the PDQ-39 and a 0.47 seconds on the TUG per year. Increasing exercise by 30 minutes/week was associated with slower declines in HRQL (-0.16 points) and mobility (-0.04 sec). The benefit of exercise on HRQL was greater in advanced PD (-0.41 points) than mild PD (-0.14 points; p < 0.02).

CONCLUSIONS

Consistently exercising and starting regular exercise after baseline were associated with small but significant positive effects on HRQL and mobility changes over two years. The greater association of exercise with HRQL in advanced PD supports improving encouragement and facilitation of exercise in advanced PD.

Authors+Show Affiliations

Center for Education in Health Sciences Northwestern University, Chicago, IL, USA.National Parkinson Foundation, Miami, FL, USA.Department of Biostatistics, University of Texas Health Science Center at Houston, Houston, TX, USA.Department of Biostatistics, University of Texas Health Science Center at Houston, Houston, TX, USA.Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto, Toronto, Canada.Thomas L. Davis, Division of Movement Disorders, Department of Neurology, Vanderbilt University, Nashville, TN, USA.Division of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.National Parkinson Foundation, Miami, FL, USA.Department of Neurology, Northwestern University, Chicago, IL, USA.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Observational Study

Language

eng

PubMed ID

27858719

Citation

Rafferty, Miriam R., et al. "Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: a Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data." Journal of Parkinson's Disease, vol. 7, no. 1, 2017, pp. 193-202.
Rafferty MR, Schmidt PN, Luo ST, et al. Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data. J Parkinsons Dis. 2017;7(1):193-202.
Rafferty, M. R., Schmidt, P. N., Luo, S. T., Li, K., Marras, C., Davis, T. L., Guttman, M., Cubillos, F., & Simuni, T. (2017). Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data. Journal of Parkinson's Disease, 7(1), 193-202. https://doi.org/10.3233/JPD-160912
Rafferty MR, et al. Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: a Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data. J Parkinsons Dis. 2017;7(1):193-202. PubMed PMID: 27858719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data. AU - Rafferty,Miriam R, AU - Schmidt,Peter N, AU - Luo,Sheng T, AU - Li,Kan, AU - Marras,Connie, AU - Davis,Thomas L, AU - Guttman,Mark, AU - Cubillos,Fernando, AU - Simuni,Tanya, AU - ,, PY - 2016/11/20/pubmed PY - 2017/11/10/medline PY - 2016/11/19/entrez KW - Parkinson disease KW - exercise KW - mobility limitations KW - quality of life KW - rehabilitation SP - 193 EP - 202 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 7 IS - 1 N2 - BACKGROUND: Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson's disease (PD). OBJECTIVE: To examine whether exercise habits were associated with changes in HRQL and mobility over two years. METHODS: We identified a cohort of National Parkinson Foundation Quality Improvement Initiative (NPF-QII) participants with three visits. HRQL and mobility were measured with the Parkinson's Disease Questionnaire (PDQ-39) and Timed Up and Go (TUG). We compared self-reported regular exercisers (≥2.5 hours/week) with people who did not exercise 2.5 hours/week. Then we quantified changes in HRQL and mobility associated with 30-minute increases in exercise, across PD severity, using mixed effects regression models. RESULTS: Participants with three observational study visits (n = 3408) were younger, with milder PD, than participants with fewer visits. After 2 years, consistent exercisers and people who started to exercise regularly after their baseline visit had smaller declines in HRQL and mobility than non-exercisers (p < 0.05). Non-exercisers worsened by 1.37 points on the PDQ-39 and a 0.47 seconds on the TUG per year. Increasing exercise by 30 minutes/week was associated with slower declines in HRQL (-0.16 points) and mobility (-0.04 sec). The benefit of exercise on HRQL was greater in advanced PD (-0.41 points) than mild PD (-0.14 points; p < 0.02). CONCLUSIONS: Consistently exercising and starting regular exercise after baseline were associated with small but significant positive effects on HRQL and mobility changes over two years. The greater association of exercise with HRQL in advanced PD supports improving encouragement and facilitation of exercise in advanced PD. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/27858719/Regular_Exercise_Quality_of_Life_and_Mobility_in_Parkinson's_Disease:_A_Longitudinal_Analysis_of_National_Parkinson_Foundation_Quality_Improvement_Initiative_Data_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JPD-160912 DB - PRIME DP - Unbound Medicine ER -