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Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications.
Addict Biol 2018; 23(1):493-502AB

Abstract

Hangover refers to the cluster of physiological and behavioral symptoms that occur following the end of a drinking episode. While hangover has been studied after the typical oral consumption of alcohol, the occurrence of hangover following intravenous (IV) alcohol administration in human laboratory studies has not been previously reported. This study characterizes hangover symptoms and post-infusion drinking behavior following acute IV alcohol administration in social drinkers. Twenty-one to thirty-year-old healthy social drinkers (n = 24) underwent an alcohol clamp session at breath alcohol concentration of 0.06 percent. Hangover symptoms as well as any post-infusion drinking that occurred between the end of the session and the following morning were assessed using the Acute Hangover Scale, and examined for influences of recent drinking history, family history of alcoholism and Sex. Results indicated a 79 percent prevalence of hangover symptoms, with the most common symptoms being 'tired', 'thirsty' and 'headache'. Recent drinking measures showed significant effects on Average Hangover Scale scores, with heavier drinkers showing greater hangover symptoms. There was a significant sex difference in average hangover scores, with females reporting higher scores than males. Subjective measures of stimulation and intoxication were also associated with Average Hangover Scale scores. The probability of post-infusion drinking was not predicted by hangover scores, but was related to recent drinking history; subjective response to alcohol was a significant mediator of this relationship. These findings demonstrate that hangover symptoms are experienced following IV alcohol administration, and extend previous studies of influences of risk factors for alcohol use disorders including recent drinking on hangover.

Authors+Show Affiliations

Section on Human Psychopharmacology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, USA.Section on Human Psychopharmacology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, USA.Section on Human Psychopharmacology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, USA.Section on Human Psychopharmacology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

27860050

Citation

Vatsalya, Vatsalya, et al. "Characterization of Hangover Following Intravenous Alcohol Exposure in Social Drinkers: Methodological and Clinical Implications." Addiction Biology, vol. 23, no. 1, 2018, pp. 493-502.
Vatsalya V, Stangl BL, Schmidt VY, et al. Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications. Addict Biol. 2018;23(1):493-502.
Vatsalya, V., Stangl, B. L., Schmidt, V. Y., & Ramchandani, V. A. (2018). Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications. Addiction Biology, 23(1), pp. 493-502. doi:10.1111/adb.12469.
Vatsalya V, et al. Characterization of Hangover Following Intravenous Alcohol Exposure in Social Drinkers: Methodological and Clinical Implications. Addict Biol. 2018;23(1):493-502. PubMed PMID: 27860050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of hangover following intravenous alcohol exposure in social drinkers: methodological and clinical implications. AU - Vatsalya,Vatsalya, AU - Stangl,Bethany L, AU - Schmidt,Veronica Y, AU - Ramchandani,Vijay A, Y1 - 2016/11/11/ PY - 2014/12/14/received PY - 2016/08/26/revised PY - 2016/10/10/accepted PY - 2016/11/20/pubmed PY - 2019/8/28/medline PY - 2016/11/19/entrez KW - Alcohol Hangover Scale (AHS) KW - drinking history KW - family history of alcoholism KW - human laboratory studies KW - subjective responses SP - 493 EP - 502 JF - Addiction biology JO - Addict Biol VL - 23 IS - 1 N2 - Hangover refers to the cluster of physiological and behavioral symptoms that occur following the end of a drinking episode. While hangover has been studied after the typical oral consumption of alcohol, the occurrence of hangover following intravenous (IV) alcohol administration in human laboratory studies has not been previously reported. This study characterizes hangover symptoms and post-infusion drinking behavior following acute IV alcohol administration in social drinkers. Twenty-one to thirty-year-old healthy social drinkers (n = 24) underwent an alcohol clamp session at breath alcohol concentration of 0.06 percent. Hangover symptoms as well as any post-infusion drinking that occurred between the end of the session and the following morning were assessed using the Acute Hangover Scale, and examined for influences of recent drinking history, family history of alcoholism and Sex. Results indicated a 79 percent prevalence of hangover symptoms, with the most common symptoms being 'tired', 'thirsty' and 'headache'. Recent drinking measures showed significant effects on Average Hangover Scale scores, with heavier drinkers showing greater hangover symptoms. There was a significant sex difference in average hangover scores, with females reporting higher scores than males. Subjective measures of stimulation and intoxication were also associated with Average Hangover Scale scores. The probability of post-infusion drinking was not predicted by hangover scores, but was related to recent drinking history; subjective response to alcohol was a significant mediator of this relationship. These findings demonstrate that hangover symptoms are experienced following IV alcohol administration, and extend previous studies of influences of risk factors for alcohol use disorders including recent drinking on hangover. SN - 1369-1600 UR - https://www.unboundmedicine.com/medline/citation/27860050/Characterization_of_hangover_following_intravenous_alcohol_exposure_in_social_drinkers:_methodological_and_clinical_implications_ L2 - https://doi.org/10.1111/adb.12469 DB - PRIME DP - Unbound Medicine ER -