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Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.
J Cell Mol Med. 2017 04; 21(4):648-657.JC

Abstract

Ferroptosis is a newly discovered type of cell death that differs from traditional apoptosis and necrosis and results from iron-dependent lipid peroxide accumulation. Ferroptotic cell death is characterized by cytological changes, including cell volume shrinkage and increased mitochondrial membrane density. Ferroptosis can be induced by two classes of small-molecule substances known as class 1 (system Xc- inhibitors) and class 2 ferroptosis inducers [glutathione peroxidase 4 (GPx4) inhibitors]. In addition to these small-molecule substances, a number of drugs (e.g. sorafenib, artemisinin and its derivatives) can induce ferroptosis. Various factors, such as the mevalonate (MVA) and sulphur-transfer pathways, play pivotal roles in the regulation of ferroptosis. Ferroptosis plays an unneglectable role in regulating the growth and proliferation of some types of tumour cells, such as lymphocytoma, ductal cell cancer of the pancreas, renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Here, we will first introduce the discovery of and research pertaining to ferroptosis; then summarize the induction mechanisms and regulatory pathways of ferroptosis; and finally, further elucidate the roles of ferroptosis in human tumourous diseases.

Authors+Show Affiliations

Department of Hepatobiliary Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.Department of Hepatobiliary Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.Department of Hepatobiliary Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.Environmental and Public Health School of Wenzhou Medical University, Wenzhou, China.Department of Hepatobiliary Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27860262

Citation

Yu, Haitao, et al. "Ferroptosis, a New Form of Cell Death, and Its Relationships With Tumourous Diseases." Journal of Cellular and Molecular Medicine, vol. 21, no. 4, 2017, pp. 648-657.
Yu H, Guo P, Xie X, et al. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. J Cell Mol Med. 2017;21(4):648-657.
Yu, H., Guo, P., Xie, X., Wang, Y., & Chen, G. (2017). Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. Journal of Cellular and Molecular Medicine, 21(4), 648-657. https://doi.org/10.1111/jcmm.13008
Yu H, et al. Ferroptosis, a New Form of Cell Death, and Its Relationships With Tumourous Diseases. J Cell Mol Med. 2017;21(4):648-657. PubMed PMID: 27860262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. AU - Yu,Haitao, AU - Guo,Pengyi, AU - Xie,Xiaozai, AU - Wang,Yi, AU - Chen,Gang, Y1 - 2016/11/10/ PY - 2016/06/26/received PY - 2016/09/08/accepted PY - 2016/11/20/pubmed PY - 2017/8/8/medline PY - 2016/11/19/entrez KW - erastin KW - ferroptosis KW - iron-dependent cell death KW - tumourous diseases SP - 648 EP - 657 JF - Journal of cellular and molecular medicine JO - J. Cell. Mol. Med. VL - 21 IS - 4 N2 - Ferroptosis is a newly discovered type of cell death that differs from traditional apoptosis and necrosis and results from iron-dependent lipid peroxide accumulation. Ferroptotic cell death is characterized by cytological changes, including cell volume shrinkage and increased mitochondrial membrane density. Ferroptosis can be induced by two classes of small-molecule substances known as class 1 (system Xc- inhibitors) and class 2 ferroptosis inducers [glutathione peroxidase 4 (GPx4) inhibitors]. In addition to these small-molecule substances, a number of drugs (e.g. sorafenib, artemisinin and its derivatives) can induce ferroptosis. Various factors, such as the mevalonate (MVA) and sulphur-transfer pathways, play pivotal roles in the regulation of ferroptosis. Ferroptosis plays an unneglectable role in regulating the growth and proliferation of some types of tumour cells, such as lymphocytoma, ductal cell cancer of the pancreas, renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Here, we will first introduce the discovery of and research pertaining to ferroptosis; then summarize the induction mechanisms and regulatory pathways of ferroptosis; and finally, further elucidate the roles of ferroptosis in human tumourous diseases. SN - 1582-4934 UR - https://www.unboundmedicine.com/medline/citation/27860262/Ferroptosis_a_new_form_of_cell_death_and_its_relationships_with_tumourous_diseases_ L2 - https://doi.org/10.1111/jcmm.13008 DB - PRIME DP - Unbound Medicine ER -