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Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry.

Abstract

BACKGROUND

Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear.

METHODS

Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline. Prospective follow-up for survival was conducted for 4966 CRC cases. Cox regression was used to compare nondrinkers with individuals who consumed, on average, 1 or more servings of alcohol per day in the years preceding their CRC diagnosis with respect to overall and disease-specific survival. Separate analyses by beverage type, stratified by patient and tumor attributes, were also performed. All models were adjusted for the age at diagnosis, sex, study site, year of diagnosis, smoking history, body mass index, and education.

RESULTS

Prediagnostic beer and liquor consumption was not associated with CRC survival; however, higher levels of wine consumption were modestly associated with a better prognosis overall (CRC-specific hazard ratio [HR], 0.70, 95% confidence interval [CI], 0.48-1.03; overall HR, 0.70; 95% CI, 0.53-0.94). Similar patterns were noted in stratified analyses.

CONCLUSIONS

These findings suggest that prediagnostic wine consumption is modestly associated with more favorable survival after CRC. Cancer 2017;123:1035-43. © 2016 American Cancer Society.

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  • Authors+Show Affiliations

    ,

    Epidemiology Department, University of Washington, Seattle, Washington. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

    ,

    Epidemiology Department, University of Washington, Seattle, Washington. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

    ,

    American Cancer Society, Atlanta, Georgia.

    ,

    Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.

    ,

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

    ,

    Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona.

    Epidemiology Department, University of Washington, Seattle, Washington. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

    Source

    Cancer 123:6 2017 May 15 pg 1035-1043

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Colorectal Neoplasms
    Female
    Humans
    Male
    Middle Aged
    Population Surveillance
    Prognosis
    Registries
    Risk Factors
    Smoking
    Surveys and Questionnaires
    Survival Analysis
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    27861761

    Citation

    Phipps, Amanda I., et al. "Prediagnostic Alcohol Consumption and Colorectal Cancer Survival: the Colon Cancer Family Registry." Cancer, vol. 123, no. 6, 2017, pp. 1035-1043.
    Phipps AI, Robinson JR, Campbell PT, et al. Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry. Cancer. 2017;123(6):1035-1043.
    Phipps, A. I., Robinson, J. R., Campbell, P. T., Win, A. K., Figueiredo, J. C., Lindor, N. M., & Newcomb, P. A. (2017). Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry. Cancer, 123(6), pp. 1035-1043. doi:10.1002/cncr.30446.
    Phipps AI, et al. Prediagnostic Alcohol Consumption and Colorectal Cancer Survival: the Colon Cancer Family Registry. Cancer. 2017 May 15;123(6):1035-1043. PubMed PMID: 27861761.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry. AU - Phipps,Amanda I, AU - Robinson,Jamaica R, AU - Campbell,Peter T, AU - Win,Aung Ko, AU - Figueiredo,Jane C, AU - Lindor,Noralane M, AU - Newcomb,Polly A, Y1 - 2016/11/08/ PY - 2016/07/07/received PY - 2016/09/07/revised PY - 2016/10/20/accepted PY - 2016/11/20/pubmed PY - 2017/6/1/medline PY - 2016/11/19/entrez KW - alcohol consumption KW - colorectal cancer KW - survival KW - tumor phenotype KW - wine SP - 1035 EP - 1043 JF - Cancer JO - Cancer VL - 123 IS - 6 N2 - BACKGROUND: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear. METHODS: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline. Prospective follow-up for survival was conducted for 4966 CRC cases. Cox regression was used to compare nondrinkers with individuals who consumed, on average, 1 or more servings of alcohol per day in the years preceding their CRC diagnosis with respect to overall and disease-specific survival. Separate analyses by beverage type, stratified by patient and tumor attributes, were also performed. All models were adjusted for the age at diagnosis, sex, study site, year of diagnosis, smoking history, body mass index, and education. RESULTS: Prediagnostic beer and liquor consumption was not associated with CRC survival; however, higher levels of wine consumption were modestly associated with a better prognosis overall (CRC-specific hazard ratio [HR], 0.70, 95% confidence interval [CI], 0.48-1.03; overall HR, 0.70; 95% CI, 0.53-0.94). Similar patterns were noted in stratified analyses. CONCLUSIONS: These findings suggest that prediagnostic wine consumption is modestly associated with more favorable survival after CRC. Cancer 2017;123:1035-43. © 2016 American Cancer Society. SN - 1097-0142 UR - https://www.unboundmedicine.com/medline/citation/27861761/Prediagnostic_alcohol_consumption_and_colorectal_cancer_survival:_The_Colon_Cancer_Family_Registry_ L2 - https://doi.org/10.1002/cncr.30446 DB - PRIME DP - Unbound Medicine ER -