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Periodontal disease and risk of non-Hodgkin lymphoma in the Health Professionals Follow-Up Study.

Abstract

Periodontal disease is a chronic inflammatory condition that has been associated with chronic diseases, including cancer. In an earlier prospective cohort analysis within the Health Professionals Follow-Up Study (HPFS), we observed a 31% higher risk of non-Hodgkin lymphoma (NHL) among participants with severe periodontal disease at baseline. Here, we extend the study with an additional 8 years of follow-up, and conduct analyses with updated periodontal disease status and NHL subtypes. The HPFS is an ongoing prospective cohort study of 51,529 men in the USA Between baseline in 1986 and 2012, 875 cases of NHL were diagnosed, including 290 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 85 diffuse large B-cell lymphomas and 91 follicular lymphomas. We performed multivariable Cox proportional hazards regression to evaluate associations of interest. History of periodontal disease at baseline was positively associated with risk of NHL overall (hazard ratio (HR) = 1.26, 95% confidence interval (CI): 1.06-1.49) and CLL/SLL (HR = 1.41, 95% CI: 1.04-1.90). With updated periodontal status, HRs were 1.30 (95% CI: 1.11-1.51) for NHL overall and 1.41 (95% CI: 1.08-1.84) for CLL/SLL. In contrast, after adjusting for periodontal disease, tooth loss was inversely associated with NHL, suggesting that other causes or consequences of tooth loss may have different implications for NHL etiology. Our findings suggest that periodontal disease is a risk factor for NHL. Whether periodontal disease is a direct or indirect cause of NHL, or is a marker of underlying systemic inflammation and/or immune dysregulation, warrants further investigation.

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  • Authors+Show Affiliations

    ,

    Slone Epidemiology Center at Boston University, Boston, MA.

    ,

    Tufts University, Medford, MA.

    ,

    Division of Hematology/Oncology, Tufts Medical Center, Boston, MA.

    ,

    Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

    ,

    Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

    Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA.

    Source

    International journal of cancer 140:5 2017 Mar 01 pg 1020-1026

    MeSH

    Adult
    Aged
    Alveolar Bone Loss
    Anti-Inflammatory Agents, Non-Steroidal
    Diabetes Mellitus
    Diet
    Female
    Follow-Up Studies
    Health Personnel
    Humans
    Inflammation
    Life Style
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Periodontal Diseases
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Smoking
    Tooth Loss

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27861844

    Citation

    Bertrand, Kimberly A., et al. "Periodontal Disease and Risk of non-Hodgkin Lymphoma in the Health Professionals Follow-Up Study." International Journal of Cancer, vol. 140, no. 5, 2017, pp. 1020-1026.
    Bertrand KA, Shingala J, Evens A, et al. Periodontal disease and risk of non-Hodgkin lymphoma in the Health Professionals Follow-Up Study. Int J Cancer. 2017;140(5):1020-1026.
    Bertrand, K. A., Shingala, J., Evens, A., Birmann, B. M., Giovannucci, E., & Michaud, D. S. (2017). Periodontal disease and risk of non-Hodgkin lymphoma in the Health Professionals Follow-Up Study. International Journal of Cancer, 140(5), pp. 1020-1026. doi:10.1002/ijc.30518.
    Bertrand KA, et al. Periodontal Disease and Risk of non-Hodgkin Lymphoma in the Health Professionals Follow-Up Study. Int J Cancer. 2017 Mar 1;140(5):1020-1026. PubMed PMID: 27861844.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Periodontal disease and risk of non-Hodgkin lymphoma in the Health Professionals Follow-Up Study. AU - Bertrand,Kimberly A, AU - Shingala,Janki, AU - Evens,Andrew, AU - Birmann,Brenda M, AU - Giovannucci,Edward, AU - Michaud,Dominique S, Y1 - 2016/11/25/ PY - 2016/06/30/received PY - 2016/11/02/accepted PY - 2016/11/20/pubmed PY - 2017/5/16/medline PY - 2016/11/19/entrez KW - epidemiology KW - non-Hodgkin lymphoma KW - periodontal disease KW - periodontitis KW - risk SP - 1020 EP - 1026 JF - International journal of cancer JO - Int. J. Cancer VL - 140 IS - 5 N2 - Periodontal disease is a chronic inflammatory condition that has been associated with chronic diseases, including cancer. In an earlier prospective cohort analysis within the Health Professionals Follow-Up Study (HPFS), we observed a 31% higher risk of non-Hodgkin lymphoma (NHL) among participants with severe periodontal disease at baseline. Here, we extend the study with an additional 8 years of follow-up, and conduct analyses with updated periodontal disease status and NHL subtypes. The HPFS is an ongoing prospective cohort study of 51,529 men in the USA Between baseline in 1986 and 2012, 875 cases of NHL were diagnosed, including 290 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 85 diffuse large B-cell lymphomas and 91 follicular lymphomas. We performed multivariable Cox proportional hazards regression to evaluate associations of interest. History of periodontal disease at baseline was positively associated with risk of NHL overall (hazard ratio (HR) = 1.26, 95% confidence interval (CI): 1.06-1.49) and CLL/SLL (HR = 1.41, 95% CI: 1.04-1.90). With updated periodontal status, HRs were 1.30 (95% CI: 1.11-1.51) for NHL overall and 1.41 (95% CI: 1.08-1.84) for CLL/SLL. In contrast, after adjusting for periodontal disease, tooth loss was inversely associated with NHL, suggesting that other causes or consequences of tooth loss may have different implications for NHL etiology. Our findings suggest that periodontal disease is a risk factor for NHL. Whether periodontal disease is a direct or indirect cause of NHL, or is a marker of underlying systemic inflammation and/or immune dysregulation, warrants further investigation. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/27861844/Periodontal_disease_and_risk_of_non_Hodgkin_lymphoma_in_the_Health_Professionals_Follow_Up_Study_ L2 - https://doi.org/10.1002/ijc.30518 DB - PRIME DP - Unbound Medicine ER -