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Translation of First North American 50 and 70 cc Total Artificial Heart Virtual and Clinical Implantations: Utility of 3D Computed Tomography to Test Fit Devices.
Artif Organs. 2017 Aug; 41(8):727-734.AO

Abstract

Since the creation of SynCardia's 50 cc Total Artificial Hearts (TAHs), patients with irreversible biventricular failure now have two sizing options. Herein, a case series of three patients who have undergone successful 50 and 70 cc TAH implantation with complete closure of the chest cavity utilizing preoperative "virtual implantation" of different sized devices for surgical planning are presented. Computed tomography (CT) images were used for preoperative planning prior to TAH implantation. Three-dimensional (3D) reconstructions of preoperative chest CT images were generated and both 50 and 70 cc TAHs were virtually implanted into patients' thoracic cavities. During the simulation, the TAHs were projected over the native hearts in a similar position to the actual implantation, and the relationship between the devices and the atria, ventricles, chest wall, and diaphragm were assessed. The 3D reconstructed images and virtual modeling were used to simulate and determine for each patient if the 50 or 70 cc TAH would have a higher likelihood of successful implantation without complications. Subsequently, all three patients received clinical implants of the properly sized TAH based on virtual modeling, and their chest cavities were fully closed. This virtual implantation increases our confidence that the selected TAH will better fit within the thoracic cavity allowing for improved surgical outcome. Clinical implantation of the TAHs showed that our virtual modeling was an effective method for determining the correct fit and sizing of 50 and 70 cc TAHs.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Ferng AS
Department of Surgery, Division of Cardiothoracic Surgery, Banner-University Medical Center. College of Medicine-Tucson, University of Arizona. Department of Physiological Sciences, University of Arizona. Department of Biomedical Engineering, University of Arizona.
Oliva I
Department of Surgery, Division of Cardiothoracic Surgery, Banner-University Medical Center. College of Medicine-Tucson, University of Arizona. Department of Medical Imaging, Banner-University Medical Center. Sarver Heart Center, University of Arizona.
Jokerst C
College of Medicine-Tucson, University of Arizona. Department of Medical Imaging, Banner-University Medical Center.
Avery R
College of Medicine-Tucson, University of Arizona. Department of Medical Imaging, Banner-University Medical Center.
Connell AM
Department of Surgery, Division of Cardiothoracic Surgery, Banner-University Medical Center. College of Medicine-Tucson, University of Arizona.
Tran PL
College of Medicine-Tucson, University of Arizona. Sarver Heart Center, University of Arizona. SynCardia Systems, Inc, Tucson, AZ, USA.
Smith RG
Sarver Heart Center, University of Arizona. SynCardia Systems, Inc, Tucson, AZ, USA.
Khalpey Z
Department of Surgery, Division of Cardiothoracic Surgery, Banner-University Medical Center. College of Medicine-Tucson, University of Arizona. Department of Physiological Sciences, University of Arizona. Department of Biomedical Engineering, University of Arizona.

MeSH

AdultFemaleHeart FailureHeart, ArtificialHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedProsthesis ImplantationTomography, X-Ray ComputedUnited StatesYoung Adult

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

27862058

Citation

Ferng, Alice S., et al. "Translation of First North American 50 and 70 Cc Total Artificial Heart Virtual and Clinical Implantations: Utility of 3D Computed Tomography to Test Fit Devices." Artificial Organs, vol. 41, no. 8, 2017, pp. 727-734.
Ferng AS, Oliva I, Jokerst C, et al. Translation of First North American 50 and 70 cc Total Artificial Heart Virtual and Clinical Implantations: Utility of 3D Computed Tomography to Test Fit Devices. Artif Organs. 2017;41(8):727-734.
Ferng, A. S., Oliva, I., Jokerst, C., Avery, R., Connell, A. M., Tran, P. L., Smith, R. G., & Khalpey, Z. (2017). Translation of First North American 50 and 70 cc Total Artificial Heart Virtual and Clinical Implantations: Utility of 3D Computed Tomography to Test Fit Devices. Artificial Organs, 41(8), 727-734. https://doi.org/10.1111/aor.12854
Ferng AS, et al. Translation of First North American 50 and 70 Cc Total Artificial Heart Virtual and Clinical Implantations: Utility of 3D Computed Tomography to Test Fit Devices. Artif Organs. 2017;41(8):727-734. PubMed PMID: 27862058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Translation of First North American 50 and 70 cc Total Artificial Heart Virtual and Clinical Implantations: Utility of 3D Computed Tomography to Test Fit Devices. AU - Ferng,Alice S, AU - Oliva,Isabel, AU - Jokerst,Clinton, AU - Avery,Ryan, AU - Connell,Alana M, AU - Tran,Phat L, AU - Smith,Richard G, AU - Khalpey,Zain, Y1 - 2016/11/10/ PY - 2016/03/11/received PY - 2016/07/21/revised PY - 2016/08/12/accepted PY - 2016/11/20/pubmed PY - 2018/5/1/medline PY - 2016/11/19/entrez KW - -3D surgical modeling KW - -Computerized tomography KW - -Magnetic resonance imaging KW - -Total artificial heart KW - Virtual implantation SP - 727 EP - 734 JF - Artificial organs JO - Artif Organs VL - 41 IS - 8 N2 - Since the creation of SynCardia's 50 cc Total Artificial Hearts (TAHs), patients with irreversible biventricular failure now have two sizing options. Herein, a case series of three patients who have undergone successful 50 and 70 cc TAH implantation with complete closure of the chest cavity utilizing preoperative "virtual implantation" of different sized devices for surgical planning are presented. Computed tomography (CT) images were used for preoperative planning prior to TAH implantation. Three-dimensional (3D) reconstructions of preoperative chest CT images were generated and both 50 and 70 cc TAHs were virtually implanted into patients' thoracic cavities. During the simulation, the TAHs were projected over the native hearts in a similar position to the actual implantation, and the relationship between the devices and the atria, ventricles, chest wall, and diaphragm were assessed. The 3D reconstructed images and virtual modeling were used to simulate and determine for each patient if the 50 or 70 cc TAH would have a higher likelihood of successful implantation without complications. Subsequently, all three patients received clinical implants of the properly sized TAH based on virtual modeling, and their chest cavities were fully closed. This virtual implantation increases our confidence that the selected TAH will better fit within the thoracic cavity allowing for improved surgical outcome. Clinical implantation of the TAHs showed that our virtual modeling was an effective method for determining the correct fit and sizing of 50 and 70 cc TAHs. SN - 1525-1594 UR - https://www.unboundmedicine.com/medline/citation/27862058/Translation_of_First_North_American_50_and_70_cc_Total_Artificial_Heart_Virtual_and_Clinical_Implantations:_Utility_of_3D_Computed_Tomography_to_Test_Fit_Devices_ DB - PRIME DP - Unbound Medicine ER -