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Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome.
J Oral Pathol Med. 2017 May; 46(5):387-392.JO

Abstract

OBJECTIVES

The aim of this study was to evaluate oxidative stress factors and C-reactive protein in the saliva of patients with oral lichen planus (OLP) and burning mouth syndrome (BMS).

METHODS

This consecutive, cross-sectional study included 20 patients with OLP, 19 with burning mouth syndrome (BMS), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire (OHIP-14) and the xerostomia inventory. The following parameters were measured in whole non-stimulated saliva: trolox equivalent antioxidant capacity (TEAC); total antioxidant capacity (TAC); cupric reducing antioxidant capacity (CUPRAC); ferric reducing ability of plasma (FRAP); C-reactive protein (CRP); nitric oxide; nitrates; and nitrites.

RESULTS

The OLP group presented statistically significant differences in reactive oxygen species (ROS) (29 600 cps) in comparison with the control group (39 679 cps) (P < 0.05). In the BMS group, ROS was 29 707 cps with significant difference in comparison with the control group (P < 0.05). Significantly higher salivary nitric oxide (145.7 μmol) and nitrite (141.0 μmol) levels were found in OLP patients in comparison with control group (P < 0.05).

CONCLUSION

Increases in nitric oxide and C-reactive protein were found in the saliva of OLP patients in comparison with BMS and control patients. Further studies are required to confirm these findings.

Authors+Show Affiliations

Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain. Department of Animal Medicine and Surgery, Veterinary School, the Autonomous University of Barcelona, Barcelona, Spain.Department of Oral Medicine, Faculty of Medicine, University of Murcia, Espinardo, Murcia, Spain.Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain.Interdisciplinary Laboratory of Clinical Analysis Interlab-UMU, Faculty of Veterinary Medicine, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Espinardo, Murcia, Spain.Department of Oral Medicine, Faculty of Medicine, University of Murcia, Espinardo, Murcia, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27862315

Citation

Tvarijonaviciute, Asta, et al. "Evaluation of Salivary Oxidate Stress Biomarkers, Nitric Oxide and C-reactive Protein in Patients With Oral Lichen Planus and Burning Mouth Syndrome." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 46, no. 5, 2017, pp. 387-392.
Tvarijonaviciute A, Aznar-Cayuela C, Rubio CP, et al. Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome. J Oral Pathol Med. 2017;46(5):387-392.
Tvarijonaviciute, A., Aznar-Cayuela, C., Rubio, C. P., Ceron, J. J., & López-Jornet, P. (2017). Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 46(5), 387-392. https://doi.org/10.1111/jop.12522
Tvarijonaviciute A, et al. Evaluation of Salivary Oxidate Stress Biomarkers, Nitric Oxide and C-reactive Protein in Patients With Oral Lichen Planus and Burning Mouth Syndrome. J Oral Pathol Med. 2017;46(5):387-392. PubMed PMID: 27862315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome. AU - Tvarijonaviciute,Asta, AU - Aznar-Cayuela,Cristina, AU - Rubio,Camila P, AU - Ceron,José J, AU - López-Jornet,Pia, Y1 - 2016/12/11/ PY - 2016/11/03/accepted PY - 2016/11/20/pubmed PY - 2018/4/5/medline PY - 2016/11/19/entrez KW - antioxidant capacity KW - burning mouth syndrome KW - markers of oxidative stress KW - oral lichen planus KW - saliva SP - 387 EP - 392 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 46 IS - 5 N2 - OBJECTIVES: The aim of this study was to evaluate oxidative stress factors and C-reactive protein in the saliva of patients with oral lichen planus (OLP) and burning mouth syndrome (BMS). METHODS: This consecutive, cross-sectional study included 20 patients with OLP, 19 with burning mouth syndrome (BMS), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire (OHIP-14) and the xerostomia inventory. The following parameters were measured in whole non-stimulated saliva: trolox equivalent antioxidant capacity (TEAC); total antioxidant capacity (TAC); cupric reducing antioxidant capacity (CUPRAC); ferric reducing ability of plasma (FRAP); C-reactive protein (CRP); nitric oxide; nitrates; and nitrites. RESULTS: The OLP group presented statistically significant differences in reactive oxygen species (ROS) (29 600 cps) in comparison with the control group (39 679 cps) (P < 0.05). In the BMS group, ROS was 29 707 cps with significant difference in comparison with the control group (P < 0.05). Significantly higher salivary nitric oxide (145.7 μmol) and nitrite (141.0 μmol) levels were found in OLP patients in comparison with control group (P < 0.05). CONCLUSION: Increases in nitric oxide and C-reactive protein were found in the saliva of OLP patients in comparison with BMS and control patients. Further studies are required to confirm these findings. SN - 1600-0714 UR - https://www.unboundmedicine.com/medline/citation/27862315/Evaluation_of_salivary_oxidate_stress_biomarkers_nitric_oxide_and_C_reactive_protein_in_patients_with_oral_lichen_planus_and_burning_mouth_syndrome_ L2 - https://doi.org/10.1111/jop.12522 DB - PRIME DP - Unbound Medicine ER -