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Prescription pattern of Chinese herbal products for heart failure in Taiwan: A population-based study.
Int J Cardiol. 2017 Feb 01; 228:90-96.IJ

Abstract

BACKGROUND

Certain Chinese herbal products (CHPs) may protect against the progression of heart failure (HF). However, there is a lack of research regarding the use of CHPs in patients with HF. The aims of this study were to analyze CHPs usage patterns in patients with HF and to identify the frequency and combination of CHPs most commonly used for HF.

METHODS

This retrospective, nationwide, population-based cohort study was conducted using a randomly sampled cohort of one million patients selected from the National Health Insurance Research Database (NHIRD) for the years 2000-2010 in Taiwan. CHP use and the top ten most frequently prescribed formulae and single herbs for treating HF were assessed, including total formulae number and average and frequency of prescriptions. Demographic characteristics, including sex and age at diagnosis of HF, were examined, together with existing comorbidities.

RESULTS

The cohort included 19,988 newly diagnosed AD patients, who were given CHP treatment for HF between 2000 and 2010. Among them, female patients (53.3%) and those over 65years old (63.9%) were more likely to use CM. After adjusting for demographic factors, HF patients suffering from coronary artery disease (CAD) were more likely to seek traditional Chinese medicine (TCM) treatment than those with non-TCM users (57.6% vs. 52.6%). Zhi-Gan-Cao-Tang (4.07%) and Danshen (5.13%) were the most frequent formula CHP and single CHP prescribed by TCM practitioners for treating HF, respectively.

CONCLUSION

Most people with HF who consumed CHPs used CHPs to supplement Yang-Qi, nourish the Ying-blood, and strengthen the heart spirit as complementary medicines to relieve HF-related symptoms, in addition to using standard anti-HF treatments. Further large-scale, randomized clinical trials are warranted in order to determine the effectiveness and safety of these herbal medicines.

Authors+Show Affiliations

Graduate Institute of Integrated Medicine, College of Chinese Medicine, Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung, Taiwan; Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; Healthcare Service Research Center (HSRC), Taichung Veterans General Hospital, Taichung, Taiwan.Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan.Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan. Electronic address: hungyuchiang@gmail.com.Graduate Institute of Integrated Medicine, College of Chinese Medicine, Research Center for Chinese Medicine & Acupuncture, China Medical University, Taichung, Taiwan; Department of Psychology, College of Medical and Health Science, Asia University, Taichung, Taiwan. Electronic address: yhchen@mail.cmu.edu.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27863367

Citation

Tsai, Ming-Yen, et al. "Prescription Pattern of Chinese Herbal Products for Heart Failure in Taiwan: a Population-based Study." International Journal of Cardiology, vol. 228, 2017, pp. 90-96.
Tsai MY, Hu WL, Lin CC, et al. Prescription pattern of Chinese herbal products for heart failure in Taiwan: A population-based study. Int J Cardiol. 2017;228:90-96.
Tsai, M. Y., Hu, W. L., Lin, C. C., Lee, Y. C., Chen, S. Y., Hung, Y. C., & Chen, Y. H. (2017). Prescription pattern of Chinese herbal products for heart failure in Taiwan: A population-based study. International Journal of Cardiology, 228, 90-96. https://doi.org/10.1016/j.ijcard.2016.11.172
Tsai MY, et al. Prescription Pattern of Chinese Herbal Products for Heart Failure in Taiwan: a Population-based Study. Int J Cardiol. 2017 Feb 1;228:90-96. PubMed PMID: 27863367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prescription pattern of Chinese herbal products for heart failure in Taiwan: A population-based study. AU - Tsai,Ming-Yen, AU - Hu,Wen-Long, AU - Lin,Che-Chen, AU - Lee,Yi-Chiao, AU - Chen,Shih-Yu, AU - Hung,Yu-Chiang, AU - Chen,Yung-Hsiang, Y1 - 2016/11/09/ PY - 2016/09/03/received PY - 2016/11/06/accepted PY - 2016/11/20/pubmed PY - 2017/11/4/medline PY - 2016/11/19/entrez KW - Chinese herbal products KW - Couplet medicinal KW - Heart failure KW - Pharmaco-epidemiology KW - Prescription pattern SP - 90 EP - 96 JF - International journal of cardiology JO - Int J Cardiol VL - 228 N2 - BACKGROUND: Certain Chinese herbal products (CHPs) may protect against the progression of heart failure (HF). However, there is a lack of research regarding the use of CHPs in patients with HF. The aims of this study were to analyze CHPs usage patterns in patients with HF and to identify the frequency and combination of CHPs most commonly used for HF. METHODS: This retrospective, nationwide, population-based cohort study was conducted using a randomly sampled cohort of one million patients selected from the National Health Insurance Research Database (NHIRD) for the years 2000-2010 in Taiwan. CHP use and the top ten most frequently prescribed formulae and single herbs for treating HF were assessed, including total formulae number and average and frequency of prescriptions. Demographic characteristics, including sex and age at diagnosis of HF, were examined, together with existing comorbidities. RESULTS: The cohort included 19,988 newly diagnosed AD patients, who were given CHP treatment for HF between 2000 and 2010. Among them, female patients (53.3%) and those over 65years old (63.9%) were more likely to use CM. After adjusting for demographic factors, HF patients suffering from coronary artery disease (CAD) were more likely to seek traditional Chinese medicine (TCM) treatment than those with non-TCM users (57.6% vs. 52.6%). Zhi-Gan-Cao-Tang (4.07%) and Danshen (5.13%) were the most frequent formula CHP and single CHP prescribed by TCM practitioners for treating HF, respectively. CONCLUSION: Most people with HF who consumed CHPs used CHPs to supplement Yang-Qi, nourish the Ying-blood, and strengthen the heart spirit as complementary medicines to relieve HF-related symptoms, in addition to using standard anti-HF treatments. Further large-scale, randomized clinical trials are warranted in order to determine the effectiveness and safety of these herbal medicines. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/27863367/Prescription_pattern_of_Chinese_herbal_products_for_heart_failure_in_Taiwan:_A_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(16)33633-6 DB - PRIME DP - Unbound Medicine ER -