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The neuronal basis of copper induced modulation of anxiety state in rat.
Acta Histochem. 2017 01; 119(1):10-17.AH

Abstract

Recently, studies have provided strong evidence indicating the involvement of trace elements in the physiopathology of psychiatric disorders, particularly anxiety. We aimed, through the present study, to describe the effect of acute exposure to Cu (10mg/kg BW) on anxiety state together with the serotoninergic and dopaminergic systems in rat by means of neurobehavioral tests (elevated plus maze, dark light box) and immunohistochemistry using anti-serotonin (5HT) and anti-tyrosine hydroxylase (TH). Our data report that Cu enhanced 5HT innervation in the dorsal raphe nucleus (DRN) together with a loss of TH expression within the ventral tegmental area (VTA), Substantia nigra compacta (SNc) and their subsequent outputs including the medial forebrain bundle (MFB) and striatum. In the elevated plus maze Cu significantly increased the time and the number of entries into the open arms, and raised the time spent in the Dark Box indicating a clear reduced anxiety state induced by Cu. The present data show for the first time a powerful neuro-modulatory potential of Cu in rat which involves primarily a dysfunction of 5HT and DA neurotransmissions.

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Authors+Show Affiliations

Abbaoui A
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco.
E L Hiba O
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco; Chouaib Doukkali University, Faculty of Sciences, Department of Biology, Morocco.
Gamrani H
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco. Electronic address: gamrani54@gmail.com.

MeSH

AnimalsAntibodiesAnxietyBehavior, AnimalCorpus StriatumDopamineDorsal Raphe NucleusGene ExpressionImmunohistochemistryInjections, IntraventricularMaleMaze LearningMedial Forebrain BundleOrganometallic CompoundsPars CompactaRatsRats, WistarSerotoninStereotaxic TechniquesSynaptic TransmissionTyrosine 3-MonooxygenaseVentral Tegmental Area

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27863709

Citation

Abbaoui, Abdellatif, et al. "The Neuronal Basis of Copper Induced Modulation of Anxiety State in Rat." Acta Histochemica, vol. 119, no. 1, 2017, pp. 10-17.
Abbaoui A, E L Hiba O, Gamrani H. The neuronal basis of copper induced modulation of anxiety state in rat. Acta Histochem. 2017;119(1):10-17.
Abbaoui, A., E L Hiba, O., & Gamrani, H. (2017). The neuronal basis of copper induced modulation of anxiety state in rat. Acta Histochemica, 119(1), 10-17. https://doi.org/10.1016/j.acthis.2016.10.003
Abbaoui A, E L Hiba O, Gamrani H. The Neuronal Basis of Copper Induced Modulation of Anxiety State in Rat. Acta Histochem. 2017;119(1):10-17. PubMed PMID: 27863709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neuronal basis of copper induced modulation of anxiety state in rat. AU - Abbaoui,Abdellatif, AU - E L Hiba,Omar, AU - Gamrani,Halima, Y1 - 2016/11/15/ PY - 2016/07/03/received PY - 2016/10/25/accepted PY - 2016/11/20/pubmed PY - 2017/1/12/medline PY - 2016/11/20/entrez KW - Anxiety KW - Copper KW - Dopamine KW - Serotonin KW - Wistar rats SP - 10 EP - 17 JF - Acta histochemica JO - Acta Histochem VL - 119 IS - 1 N2 - Recently, studies have provided strong evidence indicating the involvement of trace elements in the physiopathology of psychiatric disorders, particularly anxiety. We aimed, through the present study, to describe the effect of acute exposure to Cu (10mg/kg BW) on anxiety state together with the serotoninergic and dopaminergic systems in rat by means of neurobehavioral tests (elevated plus maze, dark light box) and immunohistochemistry using anti-serotonin (5HT) and anti-tyrosine hydroxylase (TH). Our data report that Cu enhanced 5HT innervation in the dorsal raphe nucleus (DRN) together with a loss of TH expression within the ventral tegmental area (VTA), Substantia nigra compacta (SNc) and their subsequent outputs including the medial forebrain bundle (MFB) and striatum. In the elevated plus maze Cu significantly increased the time and the number of entries into the open arms, and raised the time spent in the Dark Box indicating a clear reduced anxiety state induced by Cu. The present data show for the first time a powerful neuro-modulatory potential of Cu in rat which involves primarily a dysfunction of 5HT and DA neurotransmissions. SN - 1618-0372 UR - https://www.unboundmedicine.com/medline/citation/27863709/The_neuronal_basis_of_copper_induced_modulation_of_anxiety_state_in_rat_ DB - PRIME DP - Unbound Medicine ER -