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Fatty acid composition of serum lipids in patients with a coronary bypass operation.

Abstract

The fatty acid composition of serum phospholipids and cholesteryl esters was analysed in 71 male patients with angiographically defined three-vessel coronary artery disease (CAD) selected for a coronary bypass operation. Their 71 control subjects were matched according to age, sex, smoking, relative weight, and absence of CAD. The concentrations of fatty acids, 14:0, 16:0 and 16:1 of the serum phospholipids, were significantly (P less than 0.01, P less than 0.05 and P less than 0.01, respectively) higher in CAD patients than in the controls. On the other hand, linoleic (18:2 omega 6), linolenic (18:3 omega 3) and arachidonic (20:4 omega 6) acids were at a significantly lower level in the patients when compared to the controls. The polyunsaturated/saturated fatty acids (P/S) ratio in serum phospholipids was significantly (P less than 0.01) lower in the patients than in the controls. In the cholesteryl ester fraction the results paralleled those of the phospholipids. Significant correlations were obtained between the polyunsaturated fatty acids and the high density lipoprotein cholesterol or apolipoprotein A-I in the control subjects but most of these correlations were absent in the patients. Our present results further support the importance of linoleic acid in the protection against atherosclerosis. However, no unequivocal evidence on the possible beneficial effect of long-chain omega 3-fatty acids in comparison with omega 6-acids was obtained.

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  • Authors+Show Affiliations

    ,

    Rehabilitation Research Centre of the Social Insurance Institution, Turku City Hospital, Finland.

    , , , , ,

    Source

    Journal of internal medicine 225:5 1989 May pg 343-7

    MeSH

    Adult
    Cholesterol Esters
    Coronary Artery Bypass
    Coronary Disease
    Fatty Acids
    Humans
    Male
    Middle Aged
    Phospholipids

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    2786546

    Citation

    Marniemi, J, et al. "Fatty Acid Composition of Serum Lipids in Patients With a Coronary Bypass Operation." Journal of Internal Medicine, vol. 225, no. 5, 1989, pp. 343-7.
    Marniemi J, Lehtonen A, Inberg M, et al. Fatty acid composition of serum lipids in patients with a coronary bypass operation. J Intern Med. 1989;225(5):343-7.
    Marniemi, J., Lehtonen, A., Inberg, M., Niittymäki, K., Maatela, J., Alanen, E., & Seppänen, A. (1989). Fatty acid composition of serum lipids in patients with a coronary bypass operation. Journal of Internal Medicine, 225(5), pp. 343-7.
    Marniemi J, et al. Fatty Acid Composition of Serum Lipids in Patients With a Coronary Bypass Operation. J Intern Med. 1989;225(5):343-7. PubMed PMID: 2786546.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fatty acid composition of serum lipids in patients with a coronary bypass operation. AU - Marniemi,J, AU - Lehtonen,A, AU - Inberg,M, AU - Niittymäki,K, AU - Maatela,J, AU - Alanen,E, AU - Seppänen,A, PY - 1989/5/1/pubmed PY - 1989/5/1/medline PY - 1989/5/1/entrez SP - 343 EP - 7 JF - Journal of internal medicine JO - J. Intern. Med. VL - 225 IS - 5 N2 - The fatty acid composition of serum phospholipids and cholesteryl esters was analysed in 71 male patients with angiographically defined three-vessel coronary artery disease (CAD) selected for a coronary bypass operation. Their 71 control subjects were matched according to age, sex, smoking, relative weight, and absence of CAD. The concentrations of fatty acids, 14:0, 16:0 and 16:1 of the serum phospholipids, were significantly (P less than 0.01, P less than 0.05 and P less than 0.01, respectively) higher in CAD patients than in the controls. On the other hand, linoleic (18:2 omega 6), linolenic (18:3 omega 3) and arachidonic (20:4 omega 6) acids were at a significantly lower level in the patients when compared to the controls. The polyunsaturated/saturated fatty acids (P/S) ratio in serum phospholipids was significantly (P less than 0.01) lower in the patients than in the controls. In the cholesteryl ester fraction the results paralleled those of the phospholipids. Significant correlations were obtained between the polyunsaturated fatty acids and the high density lipoprotein cholesterol or apolipoprotein A-I in the control subjects but most of these correlations were absent in the patients. Our present results further support the importance of linoleic acid in the protection against atherosclerosis. However, no unequivocal evidence on the possible beneficial effect of long-chain omega 3-fatty acids in comparison with omega 6-acids was obtained. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/2786546/Fatty_acid_composition_of_serum_lipids_in_patients_with_a_coronary_bypass_operation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-6820&date=1989&volume=225&issue=5&spage=343 DB - PRIME DP - Unbound Medicine ER -