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Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis.
Emerg Infect Dis. 2016 12; 22(12):2063-2069.EI

Abstract

Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

27869614

Citation

Vilela, Raquel, et al. "Cutaneous Granulomas in Dolphins Caused By Novel Uncultivated Paracoccidioides Brasiliensis." Emerging Infectious Diseases, vol. 22, no. 12, 2016, pp. 2063-2069.
Vilela R, Bossart GD, St Leger JA, et al. Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis. Emerging Infect Dis. 2016;22(12):2063-2069.
Vilela, R., Bossart, G. D., St Leger, J. A., Dalton, L. M., Reif, J. S., Schaefer, A. M., McCarthy, P. J., Fair, P. A., & Mendoza, L. (2016). Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis. Emerging Infectious Diseases, 22(12), 2063-2069. https://doi.org/10.3201/eid2212.160860
Vilela R, et al. Cutaneous Granulomas in Dolphins Caused By Novel Uncultivated Paracoccidioides Brasiliensis. Emerging Infect Dis. 2016;22(12):2063-2069. PubMed PMID: 27869614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensis. AU - Vilela,Raquel, AU - Bossart,Gregory D, AU - St Leger,Judy A, AU - Dalton,Leslie M, AU - Reif,John S, AU - Schaefer,Adam M, AU - McCarthy,Peter J, AU - Fair,Patricia A, AU - Mendoza,Leonel, PY - 2016/11/22/entrez PY - 2016/11/22/pubmed PY - 2018/1/13/medline KW - Lacazia loboi KW - P. lutzii KW - Paracoccidioides brasiliensis KW - Tursiops truncatus KW - bottlenose dolphins KW - cutaneous granulomas KW - dolphins KW - fungi KW - lacaziosis KW - lobomycosis KW - paracoccidioidomycosis KW - paracoccidioidomycosis ceti KW - phylogenetic analysis SP - 2063 EP - 2069 JF - Emerging infectious diseases JO - Emerging Infect. Dis. VL - 22 IS - 12 N2 - Cutaneous granulomas in dolphins were believed to be caused by Lacazia loboi, which also causes a similar disease in humans. This hypothesis was recently challenged by reports that fungal DNA sequences from dolphins grouped this pathogen with Paracoccidioides brasiliensis. We conducted phylogenetic analysis of fungi from 6 bottlenose dolphins (Tursiops truncatus) with cutaneous granulomas and chains of yeast cells in infected tissues. Kex gene sequences of P. brasiliensis from dolphins showed 100% homology with sequences from cultivated P. brasiliensis, 73% with those of L. loboi, and 93% with those of P. lutzii. Parsimony analysis placed DNA sequences from dolphins within a cluster with human P. brasiliensis strains. This cluster was the sister taxon to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins is probably the cause of lacaziosis/lobomycosis, herein referred to as paracoccidioidomycosis ceti. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/27869614/Cutaneous_Granulomas_in_Dolphins_Caused_by_Novel_Uncultivated_Paracoccidioides_brasiliensis_ L2 - https://dx.doi.org/10.3201/eid2212.160860 DB - PRIME DP - Unbound Medicine ER -