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Daytime sleepiness and nighttime sleep quality across the full spectrum of cognitive presentations in essential tremor.
J Neurol Sci. 2016 Dec 15; 371:24-31.JN

Abstract

There is increasing evidence that essential tremor (ET) is a complex and heterogeneous disorder with nonmotor features including cognitive deficits and sleep problems. We are unaware of a study that has examined sleep deficits in ET across the full spectrum of cognitive presentations. Cross-sectional (baseline) data on self-reported nighttime sleep dysfunction and excessive daytime sleepiness were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) in 96 ET cases enrolled in a prospective study. Cases underwent a comprehensive neuropsychological assessment, and were classified as ET with normal cognition (ET-NC), ET with mild cognitive impairment (ET-MCI), and ET with dementia (ET-D). PSQI scores did not significantly differ across the three ET cognitive groups (p=0.22). ESS scores were highest (more daytime sleepiness) in the ET-MCI group, followed by the ET-D and ET-NC groups, respectively (p=0.016). We examined sleep dysfunction across the cognitive spectrum in ET. We demonstrate for the first time that excessive daytime sleepiness is greater in ET-MCI than ET-NC. Unpredicted low ESS scores in the dementia group raises two possibilities: a self-report bias related to cognitive impairment and/or the possibility that currently undefined pathological heterogeneity in ET may map onto multiple presentations of non-motor deficits.

Authors+Show Affiliations

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, 15 York Street, New Haven, CT 06510, USA.Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, 15 York Street, New Haven, CT 06510, USA.Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, 15 York Street, New Haven, CT 06510, USA.Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032,USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA.Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032,USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA; Division of Geriatric Psychiatry, Department of Psychiatry, College of Physicians and Surgeons, New York Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, 15 York Street, New Haven, CT 06510, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, 333 Cedar Street, New Haven, CT 06510, USA; Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT, USA. Electronic address: elan.louis@yale.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27871441

Citation

Rohl, Brittany, et al. "Daytime Sleepiness and Nighttime Sleep Quality Across the Full Spectrum of Cognitive Presentations in Essential Tremor." Journal of the Neurological Sciences, vol. 371, 2016, pp. 24-31.
Rohl B, Collins K, Morgan S, et al. Daytime sleepiness and nighttime sleep quality across the full spectrum of cognitive presentations in essential tremor. J Neurol Sci. 2016;371:24-31.
Rohl, B., Collins, K., Morgan, S., Cosentino, S., Huey, E. D., & Louis, E. D. (2016). Daytime sleepiness and nighttime sleep quality across the full spectrum of cognitive presentations in essential tremor. Journal of the Neurological Sciences, 371, 24-31. https://doi.org/10.1016/j.jns.2016.10.006
Rohl B, et al. Daytime Sleepiness and Nighttime Sleep Quality Across the Full Spectrum of Cognitive Presentations in Essential Tremor. J Neurol Sci. 2016 Dec 15;371:24-31. PubMed PMID: 27871441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daytime sleepiness and nighttime sleep quality across the full spectrum of cognitive presentations in essential tremor. AU - Rohl,Brittany, AU - Collins,Kathleen, AU - Morgan,Sarah, AU - Cosentino,Stephanie, AU - Huey,Edward D, AU - Louis,Elan D, Y1 - 2016/10/08/ PY - 2016/06/17/received PY - 2016/09/06/revised PY - 2016/10/06/accepted PY - 2016/11/23/entrez PY - 2016/11/23/pubmed PY - 2017/5/27/medline KW - Clinical KW - Cognition KW - Dementia KW - Essential tremor KW - Sleep SP - 24 EP - 31 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 371 N2 - There is increasing evidence that essential tremor (ET) is a complex and heterogeneous disorder with nonmotor features including cognitive deficits and sleep problems. We are unaware of a study that has examined sleep deficits in ET across the full spectrum of cognitive presentations. Cross-sectional (baseline) data on self-reported nighttime sleep dysfunction and excessive daytime sleepiness were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) in 96 ET cases enrolled in a prospective study. Cases underwent a comprehensive neuropsychological assessment, and were classified as ET with normal cognition (ET-NC), ET with mild cognitive impairment (ET-MCI), and ET with dementia (ET-D). PSQI scores did not significantly differ across the three ET cognitive groups (p=0.22). ESS scores were highest (more daytime sleepiness) in the ET-MCI group, followed by the ET-D and ET-NC groups, respectively (p=0.016). We examined sleep dysfunction across the cognitive spectrum in ET. We demonstrate for the first time that excessive daytime sleepiness is greater in ET-MCI than ET-NC. Unpredicted low ESS scores in the dementia group raises two possibilities: a self-report bias related to cognitive impairment and/or the possibility that currently undefined pathological heterogeneity in ET may map onto multiple presentations of non-motor deficits. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/27871441/Daytime_sleepiness_and_nighttime_sleep_quality_across_the_full_spectrum_of_cognitive_presentations_in_essential_tremor_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(16)30637-2 DB - PRIME DP - Unbound Medicine ER -