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MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment.
Semin Cell Dev Biol 2017; 67:56-64SC

Abstract

Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in animal and clinical studies. The efficacy of MSC-based therapies which was previously predicated on the chondrogenic potential of MSC is increasingly attributed to the paracrine secretion, particularly exosomes. Exosomes are thought to function primarily as intercellular communication vehicles to transfer bioactive lipids, nucleic acids (mRNAs and microRNAs) and proteins between cells to elicit biological responses in recipient cells. For MSC exosomes, many of these biological responses translated to a therapeutic outcome in injured or diseased cells. Here, we review the current understanding of MSC exosomes, discuss the possible mechanisms of action in cartilage repair within the context of the widely reported immunomodulatory and regenerative potency of MSC exosomes, and provide new perspectives for development of an off-the-shelf and cell-free MSC therapy for treatment of cartilage injuries and osteoarthritis.

Authors+Show Affiliations

Faculty of Dentistry, National University of Singapore, Singapore; Tissue Engineering Program, Life Sciences Institute National University of Singapore, Singapore. Electronic address: dentohws@nus.edu.sg.Institute of Medical Biology, Agency for Science, Technology and Research, Singapore.Tissue Engineering Program, Life Sciences Institute National University of Singapore, Singapore; Cartilage Repair Program, Therapeutic Tissue Engineering Laboratory, Department of Orthopaedic Surgery, National University Health System, National University of Singapore, Singapore.Institute of Medical Biology, Agency for Science, Technology and Research, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: saikiang.lim@imb.a-star.edu.sg.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27871993

Citation

Toh, Wei Seong, et al. "MSC Exosome as a Cell-free MSC Therapy for Cartilage Regeneration: Implications for Osteoarthritis Treatment." Seminars in Cell & Developmental Biology, vol. 67, 2017, pp. 56-64.
Toh WS, Lai RC, Hui JHP, et al. MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. Semin Cell Dev Biol. 2017;67:56-64.
Toh, W. S., Lai, R. C., Hui, J. H. P., & Lim, S. K. (2017). MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. Seminars in Cell & Developmental Biology, 67, pp. 56-64. doi:10.1016/j.semcdb.2016.11.008.
Toh WS, et al. MSC Exosome as a Cell-free MSC Therapy for Cartilage Regeneration: Implications for Osteoarthritis Treatment. Semin Cell Dev Biol. 2017;67:56-64. PubMed PMID: 27871993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. AU - Toh,Wei Seong, AU - Lai,Ruenn Chai, AU - Hui,James Hoi Po, AU - Lim,Sai Kiang, Y1 - 2016/11/18/ PY - 2016/09/26/received PY - 2016/11/17/revised PY - 2016/11/18/accepted PY - 2016/11/23/pubmed PY - 2018/3/23/medline PY - 2016/11/23/entrez KW - Cartilage KW - Chondrocytes KW - Exosomes KW - Extracellular vesicles KW - Mesenchymal stem/stromal cells KW - Tissue engineering KW - Tissue regeneration SP - 56 EP - 64 JF - Seminars in cell & developmental biology JO - Semin. Cell Dev. Biol. VL - 67 N2 - Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in animal and clinical studies. The efficacy of MSC-based therapies which was previously predicated on the chondrogenic potential of MSC is increasingly attributed to the paracrine secretion, particularly exosomes. Exosomes are thought to function primarily as intercellular communication vehicles to transfer bioactive lipids, nucleic acids (mRNAs and microRNAs) and proteins between cells to elicit biological responses in recipient cells. For MSC exosomes, many of these biological responses translated to a therapeutic outcome in injured or diseased cells. Here, we review the current understanding of MSC exosomes, discuss the possible mechanisms of action in cartilage repair within the context of the widely reported immunomodulatory and regenerative potency of MSC exosomes, and provide new perspectives for development of an off-the-shelf and cell-free MSC therapy for treatment of cartilage injuries and osteoarthritis. SN - 1096-3634 UR - https://www.unboundmedicine.com/medline/citation/27871993/MSC_exosome_as_a_cell_free_MSC_therapy_for_cartilage_regeneration:_Implications_for_osteoarthritis_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1084-9521(16)30403-7 DB - PRIME DP - Unbound Medicine ER -