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Extracorporeal membrane oxygenation: beyond rescue therapy for acute respiratory distress syndrome?
Curr Opin Crit Care. 2017 Feb; 23(1):60-65.CO

Abstract

PURPOSE OF REVIEW

This article summarizes the results of past and more recent series on venovenous extracorporeal membrane oxygenation (VV-ECMO) and discusses its potential indications beyond the rescue of patients with lung failure refractory to conventional mechanical ventilation.

RECENT FINDINGS

Successful VV-ECMO treatment in patients with extremely severe influenza A(H1N1)-associated acute respiratory distress syndrome (ARDS) and positive results of the CESAR trial have led to an exponential use of the technology in recent years. Beyond its currently accepted indication as a salvage therapy in ARDS patients with refractory hypoxemia or unable to tolerate volume-limited strategies, VV-ECMO may improve the outcomes of less severe ARDS patients by facilitating lung-protective ventilation.

SUMMARY

As initiation of VV-ECMO allows significant decrease in tidal volume, plateau and driving pressures, which has been associated with improved survival in ARDS patients, new trials should evaluate the impact of its early initiation in patients with severe but not refractory ARDS.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Combes A
aMedical Intensive Care Unit, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris bSorbonne Pierre-Marie Curie University Paris, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France.
Bréchot N
No affiliation info available
Luyt CE
No affiliation info available
Schmidt M
No affiliation info available

MeSH

Extracorporeal Membrane OxygenationHumansHypoxiaInfluenza A Virus, H1N1 SubtypeRespiration, ArtificialRespiratory Distress SyndromeSalvage TherapyTidal Volume

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27875409

Citation

Combes, Alain, et al. "Extracorporeal Membrane Oxygenation: Beyond Rescue Therapy for Acute Respiratory Distress Syndrome?" Current Opinion in Critical Care, vol. 23, no. 1, 2017, pp. 60-65.
Combes A, Bréchot N, Luyt CE, et al. Extracorporeal membrane oxygenation: beyond rescue therapy for acute respiratory distress syndrome? Curr Opin Crit Care. 2017;23(1):60-65.
Combes, A., Bréchot, N., Luyt, C. E., & Schmidt, M. (2017). Extracorporeal membrane oxygenation: beyond rescue therapy for acute respiratory distress syndrome? Current Opinion in Critical Care, 23(1), 60-65. https://doi.org/10.1097/MCC.0000000000000375
Combes A, et al. Extracorporeal Membrane Oxygenation: Beyond Rescue Therapy for Acute Respiratory Distress Syndrome. Curr Opin Crit Care. 2017;23(1):60-65. PubMed PMID: 27875409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extracorporeal membrane oxygenation: beyond rescue therapy for acute respiratory distress syndrome? AU - Combes,Alain, AU - Bréchot,Nicolas, AU - Luyt,Charles-Edouard, AU - Schmidt,Matthieu, PY - 2016/11/23/pubmed PY - 2018/5/15/medline PY - 2016/11/23/entrez SP - 60 EP - 65 JF - Current opinion in critical care JO - Curr Opin Crit Care VL - 23 IS - 1 N2 - PURPOSE OF REVIEW: This article summarizes the results of past and more recent series on venovenous extracorporeal membrane oxygenation (VV-ECMO) and discusses its potential indications beyond the rescue of patients with lung failure refractory to conventional mechanical ventilation. RECENT FINDINGS: Successful VV-ECMO treatment in patients with extremely severe influenza A(H1N1)-associated acute respiratory distress syndrome (ARDS) and positive results of the CESAR trial have led to an exponential use of the technology in recent years. Beyond its currently accepted indication as a salvage therapy in ARDS patients with refractory hypoxemia or unable to tolerate volume-limited strategies, VV-ECMO may improve the outcomes of less severe ARDS patients by facilitating lung-protective ventilation. SUMMARY: As initiation of VV-ECMO allows significant decrease in tidal volume, plateau and driving pressures, which has been associated with improved survival in ARDS patients, new trials should evaluate the impact of its early initiation in patients with severe but not refractory ARDS. SN - 1531-7072 UR - https://www.unboundmedicine.com/medline/citation/27875409/Extracorporeal_membrane_oxygenation:_beyond_rescue_therapy_for_acute_respiratory_distress_syndrome DB - PRIME DP - Unbound Medicine ER -