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Zataria multiflora Bioss: lethal effects of methanolic extract against protoscoleces of Echinococcus granulosus.

Abstract

The present study was aimed to evaluate the lethal effects of Zataria multiflora Boiss (Lamiaceae) methanolic extract against Echinococcus granulosus protoscoleces. Protoscoleces were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (2.5-20 mg/mL) were used for 10-60 min. Viability of protoscoleces was confirmed using eosin exclusion test (0.1 % eosin staining). Obtained results showed that Z. multiflora extract at the concentration of 20 mg/mL after 10 min of exposure killed 100 % protoscoleces. The mean of mortality rate of protoscoleces after 20 min of exposure to the concentration of 10 mg/mL was also 100 %. Lower concentrations of Z. multiflora extract provoked a delayed protoscolicidal activity. The findings indicated potential of Z. multiflora methanolic extract as a natural source for the producing of new scolicidal agent for use in hydatid cyst surgery.

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  • Authors+Show Affiliations

    ,

    Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.

    ,

    Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

    ,

    Department of Medical Parasitology, Iran University of Medical Sciences, Tehran, Iran.

    ,

    Department of Medical Parasitology, Jundishapour University of Medical Sciences, Ahvaz, Iran.

    Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27876932

    Citation

    Jahanbakhsh, Sareh, et al. "Zataria Multiflora Bioss: Lethal Effects of Methanolic Extract Against Protoscoleces of Echinococcus Granulosus." Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology, vol. 40, no. 4, 2016, pp. 1289-1292.
    Jahanbakhsh S, Azadpour M, Tavakoli Kareshk A, et al. Zataria multiflora Bioss: lethal effects of methanolic extract against protoscoleces of Echinococcus granulosus. J Parasit Dis. 2016;40(4):1289-1292.
    Jahanbakhsh, S., Azadpour, M., Tavakoli Kareshk, A., Keyhani, A., & Mahmoudvand, H. (2016). Zataria multiflora Bioss: lethal effects of methanolic extract against protoscoleces of Echinococcus granulosus. Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology, 40(4), pp. 1289-1292.
    Jahanbakhsh S, et al. Zataria Multiflora Bioss: Lethal Effects of Methanolic Extract Against Protoscoleces of Echinococcus Granulosus. J Parasit Dis. 2016;40(4):1289-1292. PubMed PMID: 27876932.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Zataria multiflora Bioss: lethal effects of methanolic extract against protoscoleces of Echinococcus granulosus. AU - Jahanbakhsh,Sareh, AU - Azadpour,Mojgan, AU - Tavakoli Kareshk,Amir, AU - Keyhani,Amir, AU - Mahmoudvand,Hossein, Y1 - 2015/03/14/ PY - 2015/02/07/received PY - 2015/02/20/accepted PY - 2016/11/24/entrez PY - 2016/11/24/pubmed PY - 2016/11/24/medline KW - Cystic echinococcosis KW - Protoscoleces KW - Scolicidal KW - Zataria multiflora Boiss SP - 1289 EP - 1292 JF - Journal of parasitic diseases : official organ of the Indian Society for Parasitology JO - J Parasit Dis VL - 40 IS - 4 N2 - The present study was aimed to evaluate the lethal effects of Zataria multiflora Boiss (Lamiaceae) methanolic extract against Echinococcus granulosus protoscoleces. Protoscoleces were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (2.5-20 mg/mL) were used for 10-60 min. Viability of protoscoleces was confirmed using eosin exclusion test (0.1 % eosin staining). Obtained results showed that Z. multiflora extract at the concentration of 20 mg/mL after 10 min of exposure killed 100 % protoscoleces. The mean of mortality rate of protoscoleces after 20 min of exposure to the concentration of 10 mg/mL was also 100 %. Lower concentrations of Z. multiflora extract provoked a delayed protoscolicidal activity. The findings indicated potential of Z. multiflora methanolic extract as a natural source for the producing of new scolicidal agent for use in hydatid cyst surgery. SN - 0971-7196 UR - https://www.unboundmedicine.com/medline/citation/27876932/Zataria_multiflora_Bioss:_lethal_effects_of_methanolic_extract_against_protoscoleces_of_Echinococcus_granulosus_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27876932/ DB - PRIME DP - Unbound Medicine ER -