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Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell.
J Cancer 2016; 7(14):2132-2138JC

Abstract

The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in bladder cancer, we overexpress YAP in bladder cancer cells and discover that YAP is able to promote bladder cancer cell growth and migration. In addition, we provide evidence that knockdown of Mask2 is able to repress bladder cancer cell growth and migration. Furthermore, we demonstrate knockdown of Mask2 is able to inhibit bladder cancer cell growth and migration induced by the excessive YAP. To explain the function of YAP/Mask2 complex in bladder cancer, we check the target genes' expression of Hippo signaling pathway involved in cell growth and migration and find overexpressed YAP is able to upregulate the target genes' expression while depletion of Mask2 downregulates them. Taken together, we demonstrate that Mask2 is required for the function of bladder cancer cell growth and migration induced by YAP via the target genes of Hippo pathway.

Authors+Show Affiliations

State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, PR China.State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, PR China.State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, PR China.State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, PR China.State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27877230

Citation

Dong, Liang, et al. "Transcriptional Cofactor Mask2 Is Required for YAP-induced Cell Growth and Migration in Bladder Cancer Cell." Journal of Cancer, vol. 7, no. 14, 2016, pp. 2132-2138.
Dong L, Lin F, Wu W, et al. Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell. J Cancer. 2016;7(14):2132-2138.
Dong, L., Lin, F., Wu, W., Huang, W., & Cai, Z. (2016). Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell. Journal of Cancer, 7(14), pp. 2132-2138.
Dong L, et al. Transcriptional Cofactor Mask2 Is Required for YAP-induced Cell Growth and Migration in Bladder Cancer Cell. J Cancer. 2016;7(14):2132-2138. PubMed PMID: 27877230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell. AU - Dong,Liang, AU - Lin,Fan, AU - Wu,Wanjun, AU - Huang,Weiren, AU - Cai,Zhiming, Y1 - 2016/10/23/ PY - 2016/06/09/received PY - 2016/09/03/accepted PY - 2016/11/24/entrez PY - 2016/11/24/pubmed PY - 2016/11/24/medline KW - Mask2 KW - YAP KW - bladder cancer KW - cell growth and migration SP - 2132 EP - 2138 JF - Journal of Cancer JO - J Cancer VL - 7 IS - 14 N2 - The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in bladder cancer, we overexpress YAP in bladder cancer cells and discover that YAP is able to promote bladder cancer cell growth and migration. In addition, we provide evidence that knockdown of Mask2 is able to repress bladder cancer cell growth and migration. Furthermore, we demonstrate knockdown of Mask2 is able to inhibit bladder cancer cell growth and migration induced by the excessive YAP. To explain the function of YAP/Mask2 complex in bladder cancer, we check the target genes' expression of Hippo signaling pathway involved in cell growth and migration and find overexpressed YAP is able to upregulate the target genes' expression while depletion of Mask2 downregulates them. Taken together, we demonstrate that Mask2 is required for the function of bladder cancer cell growth and migration induced by YAP via the target genes of Hippo pathway. SN - 1837-9664 UR - https://www.unboundmedicine.com/medline/citation/27877230/Transcriptional_cofactor_Mask2_is_required_for_YAP_induced_cell_growth_and_migration_in_bladder_cancer_cell_ L2 - http://www.jcancer.org/v07p2132.htm DB - PRIME DP - Unbound Medicine ER -