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Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode.
Sensors (Basel). 2008 Jun 12; 8(6):3952-3969.S

Abstract

Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM - 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors.

Authors+Show Affiliations

University of Medicine and Pharmacy "Victor Babes" Timisoara, PiaŃa E. Murgu, Nr. 2, 300041 Timisoara, Romania. cofancodruta@umft.ro.West University of Timisoara, Laboratory of Electrochemistry, Str. Pestalozzi Nr.16, 300115 Timisoara, Romania. radovan@cbg.uvt.ro.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27879917

Citation

Cofan, Codruţa, and Ciprian Radovan. "Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode." Sensors (Basel, Switzerland), vol. 8, no. 6, 2008, pp. 3952-3969.
Cofan C, Radovan C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors (Basel). 2008;8(6):3952-3969.
Cofan, C., & Radovan, C. (2008). Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors (Basel, Switzerland), 8(6), 3952-3969.
Cofan C, Radovan C. Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. Sensors (Basel). 2008 Jun 12;8(6):3952-3969. PubMed PMID: 27879917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous Chronoamperometric Sensing of Ascorbic Acid and Acetaminophen at a Boron-Doped Diamond Electrode. AU - Cofan,Codruţa, AU - Radovan,Ciprian, Y1 - 2008/06/12/ PY - 2008/05/21/received PY - 2008/06/09/revised PY - 2008/06/09/accepted PY - 2016/11/24/entrez PY - 2008/6/12/pubmed PY - 2008/6/12/medline KW - acetaminophen KW - ascorbic acid KW - boron-doped diamond electrode KW - buffered media. KW - chronoamperometry SP - 3952 EP - 3969 JF - Sensors (Basel, Switzerland) JO - Sensors (Basel) VL - 8 IS - 6 N2 - Cyclic voltammetry (CV) and chronoamperometry (CA) have been used to sense and determine simultaneously L-ascorbic acid (AA) and acetaminophen (AC) at a boron-doped diamond electrode (BDDE) in a Britton-Robinson buffer solution. The calibration plots of anodic current peak versus concentration obtained from CV and CA data for both investigated compounds in single and di-component solutions over the concentration range 0.01 mM - 0.1 mM proved to be linear, with very good correlation parameters. Sensitivity values and RSD of 2-3% were obtained for various situations, involving both individual and simultaneous presence of AA and AC. The chronoamperometric technique associated with standard addition in sequential one step and/or two successive and continuous chronoamperograms at two characteristic potential levels represented a feasible option for the simultaneous determination of AA and AC in real sample systems such as pharmaceutical formulations. The average values indicated by the supplier were confirmed to a very close approximation from chronoamperomgrams by using several additions with the application of suitable current correction factors. SN - 1424-8220 UR - https://www.unboundmedicine.com/medline/citation/27879917/Simultaneous_Chronoamperometric_Sensing_of_Ascorbic_Acid_and_Acetaminophen_at_a_Boron_Doped_Diamond_Electrode_ L2 - https://www.mdpi.com/resolver?pii=s8063952 DB - PRIME DP - Unbound Medicine ER -
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