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Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon?
Pharmacol Res. 2017 01; 115:200-208.PR

Abstract

The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types 1 and 2 (CB1 and CB2) for marijuana's psychoactive ingredient Δ9-tetrahydrocannabinol (Δ9-THC), the endogenous ligands (AEA and 2-AG) and the enzymatic systems involved in their biosynthesis and degradation, recently emerged as important modulator of emotional and non-emotional behaviors. For centuries, in addition to its recreational actions, several contradictory claims regarding the effects of Cannabis use in sexual functioning and behavior (e.g. aphrodisiac vs anti-aphrodisiac) of both sexes have been accumulated. The identification of Δ9-THC and later on, the discovery of the ECS have opened a potential therapeutic target for sexual dysfunctions, given the partial efficacy of current pharmacological treatment. In agreement with the bidirectional modulation induced by cannabinoids on several behavioral responses, the endogenous cannabinoid AEA elicited biphasic effects on sexual behavior as well. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of several aspects of sexuality in preclinical and human studies, highlighting their therapeutic potential.

Authors+Show Affiliations

National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.National Institute of Mental Health, Klecany, Czech Republic; 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic. Electronic address: vincenzomicale@inwind.it.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27884725

Citation

Androvicova, Renata, et al. "Endocannabinoid System in Sexual Motivational Processes: Is It a Novel Therapeutic Horizon?" Pharmacological Research, vol. 115, 2017, pp. 200-208.
Androvicova R, Horacek J, Stark T, et al. Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? Pharmacol Res. 2017;115:200-208.
Androvicova, R., Horacek, J., Stark, T., Drago, F., & Micale, V. (2017). Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? Pharmacological Research, 115, 200-208. https://doi.org/10.1016/j.phrs.2016.11.021
Androvicova R, et al. Endocannabinoid System in Sexual Motivational Processes: Is It a Novel Therapeutic Horizon. Pharmacol Res. 2017;115:200-208. PubMed PMID: 27884725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? AU - Androvicova,Renata, AU - Horacek,Jiri, AU - Stark,Tibor, AU - Drago,Filippo, AU - Micale,Vincenzo, Y1 - 2016/11/21/ PY - 2016/06/24/received PY - 2016/11/20/revised PY - 2016/11/20/accepted PY - 2016/11/26/pubmed PY - 2017/12/28/medline PY - 2016/11/26/entrez KW - Cannabinoid CB1 receptor KW - Endocannabinoids KW - Sexual behavior KW - Δ(9)-THC SP - 200 EP - 208 JF - Pharmacological research JO - Pharmacol. Res. VL - 115 N2 - The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types 1 and 2 (CB1 and CB2) for marijuana's psychoactive ingredient Δ9-tetrahydrocannabinol (Δ9-THC), the endogenous ligands (AEA and 2-AG) and the enzymatic systems involved in their biosynthesis and degradation, recently emerged as important modulator of emotional and non-emotional behaviors. For centuries, in addition to its recreational actions, several contradictory claims regarding the effects of Cannabis use in sexual functioning and behavior (e.g. aphrodisiac vs anti-aphrodisiac) of both sexes have been accumulated. The identification of Δ9-THC and later on, the discovery of the ECS have opened a potential therapeutic target for sexual dysfunctions, given the partial efficacy of current pharmacological treatment. In agreement with the bidirectional modulation induced by cannabinoids on several behavioral responses, the endogenous cannabinoid AEA elicited biphasic effects on sexual behavior as well. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of several aspects of sexuality in preclinical and human studies, highlighting their therapeutic potential. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/27884725/Endocannabinoid_system_in_sexual_motivational_processes:_Is_it_a_novel_therapeutic_horizon L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(16)31238-5 DB - PRIME DP - Unbound Medicine ER -