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A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women.

Abstract

This prospective study sought to investigate serum levels of trace elements (cobalt, copper, zinc, and selenium) and to assess their effects on pregnancy and neonatal outcomes. Serum levels of trace elements in 245 Korean pregnant women (median gestational age at delivery was 39 + 4 weeks and interquartile range was 38 + 4-40 + 1 weeks) were compared with those of 527 general adults and those of previous studies in other ethnic groups. Pregnancy and neonatal outcomes including gestational diabetes, preeclampsia, neonatal birth weight, and congenital abnormalities were assessed. The median serum trace element concentrations of all pregnant women were: cobalt: 0.39 μg/L (interquartile range, IQR 0.29-0.53), copper: 165.0 μg/dL (IQR 144.0-187.0), zinc: 57.0 μg/dL (IQR 50.0-64.0), and selenium: 94.0 μg/L (IQR 87.0-101.0). Serum cobalt and copper concentrations were higher in pregnant women than in the general population, whereas zinc and selenium levels were lower (p < 0.01). Concentrations of all four trace elements varied significantly during the three trimesters (p < 0.05), and seasonal variation was found in copper, zinc, and selenium, but was not observed for cobalt. The prevalence of preeclampsia was significantly lower with high copper (p = 0.03). Trace element levels varied by pregnancy trimester and season, and alteration in copper status during pregnancy might influence pregnancy outcomes such as preeclampsia.

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  • Authors+Show Affiliations

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    Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. rihwa.choi@samsung.com.

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    Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. jiyu.sun@sbri.co.kr.

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    Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. heejin.yoo@sbri.co.kr.

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    Statistics and Dater Center, Samsung Biomedical Research Institute, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. seonwoo1.kim@samsung.com.

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    Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. yoonung2@hanmail.net.

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    Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. eyedr53@schmc.ac.kr.

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    Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. sunwooksmc.kim@samsung.com.

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    Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. jaeh.chung@samsung.com.

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    Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. ohsymd.oh@samsung.com.

    Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. sy117.lee@samsung.com. Department of Clinical Pharmacology & Therapeutics, Samsung Medical Center, 81 Irwon-Ro, Gangnam-Gu, Seoul 06351, Korea. sy117.lee@samsung.com.

    Source

    Nutrients 8:11 2016 Nov 23 pg

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Biomarkers
    Case-Control Studies
    Cobalt
    Copper
    Female
    Health Status
    Healthy Volunteers
    Humans
    Male
    Middle Aged
    Pre-Eclampsia
    Pregnancy
    Pregnancy Outcome
    Pregnancy Trimesters
    Prevalence
    Prospective Studies
    Republic of Korea
    Seasons
    Selenium
    Trace Elements
    Young Adult
    Zinc

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27886083

    Citation

    Choi, Rihwa, et al. "A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women." Nutrients, vol. 8, no. 11, 2016.
    Choi R, Sun J, Yoo H, et al. A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women. Nutrients. 2016;8(11).
    Choi, R., Sun, J., Yoo, H., Kim, S., Cho, Y. Y., Kim, H. J., ... Lee, S. Y. (2016). A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women. Nutrients, 8(11).
    Choi R, et al. A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women. Nutrients. 2016 Nov 23;8(11) PubMed PMID: 27886083.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A Prospective Study of Serum Trace Elements in Healthy Korean Pregnant Women. AU - Choi,Rihwa, AU - Sun,Jiyu, AU - Yoo,Heejin, AU - Kim,Seonwoo, AU - Cho,Yoon Young, AU - Kim,Hye Jeong, AU - Kim,Sun Wook, AU - Chung,Jae Hoon, AU - Oh,Soo-Young, AU - Lee,Soo-Youn, Y1 - 2016/11/23/ PY - 2016/10/31/received PY - 2016/11/16/revised PY - 2016/11/17/accepted PY - 2016/11/26/entrez PY - 2016/11/26/pubmed PY - 2017/4/11/medline KW - cobalt KW - copper KW - pregnancy KW - selenium KW - trace elements KW - zinc JF - Nutrients JO - Nutrients VL - 8 IS - 11 N2 - This prospective study sought to investigate serum levels of trace elements (cobalt, copper, zinc, and selenium) and to assess their effects on pregnancy and neonatal outcomes. Serum levels of trace elements in 245 Korean pregnant women (median gestational age at delivery was 39 + 4 weeks and interquartile range was 38 + 4-40 + 1 weeks) were compared with those of 527 general adults and those of previous studies in other ethnic groups. Pregnancy and neonatal outcomes including gestational diabetes, preeclampsia, neonatal birth weight, and congenital abnormalities were assessed. The median serum trace element concentrations of all pregnant women were: cobalt: 0.39 μg/L (interquartile range, IQR 0.29-0.53), copper: 165.0 μg/dL (IQR 144.0-187.0), zinc: 57.0 μg/dL (IQR 50.0-64.0), and selenium: 94.0 μg/L (IQR 87.0-101.0). Serum cobalt and copper concentrations were higher in pregnant women than in the general population, whereas zinc and selenium levels were lower (p < 0.01). Concentrations of all four trace elements varied significantly during the three trimesters (p < 0.05), and seasonal variation was found in copper, zinc, and selenium, but was not observed for cobalt. The prevalence of preeclampsia was significantly lower with high copper (p = 0.03). Trace element levels varied by pregnancy trimester and season, and alteration in copper status during pregnancy might influence pregnancy outcomes such as preeclampsia. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/27886083/A_Prospective_Study_of_Serum_Trace_Elements_in_Healthy_Korean_Pregnant_Women_ L2 - http://www.mdpi.com/resolver?pii=nu8110749 DB - PRIME DP - Unbound Medicine ER -