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Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS.
Lipids Health Dis. 2016 Nov 25; 15(1):206.LH

Abstract

It has been suggested that aspirin may be of benefit in treating sepsis and ARDS in view of its ability to block cyclo-oxygenase-1 (COX-1) and COX-2 activities; inhibit nuclear factor kappa B (NF-κB); enhance the production of endothelial nitric oxide (eNO) and lipoxin A4 (LXA4). Our previous studies revealed that plasma phospholipid content of arachidonic acid (AA) and eicosapentaenoic acid (EPA) is low in patients with sepsis. This implies that beneficial actions of aspirin in sepsis and ARDS is unlikely to be obtained in view of deficiency of AA and EPA, the precursors of LXA4 and resolvins respectively that are potent anti-inflammatory compounds and enhancers of eNO generation. In view of this, I propose that a combination of aspirin and AA and EPA (and possibly, docosahexaenoic acid, DHA) is likely to be superior in the management of sepsis and ARDS compared to aspirin alone. This suggestion is supported by the recent observation that trauma patients with uncomplicated recoveries had higher resolvin pathway gene expression and lower gene expression ratios of leukotriene: resolvin pathways.

Authors+Show Affiliations

UND Life Sciences, 2020 S 360th St, # K-202, Federal Way, WA, 98003, USA. Undurti@hotmail.com. BioScience Research Centre, GVP College of Engineering Campus and Department of Medicine, GVP Hospital, Madhurawada, Visakhapatnam, 530 048, India. Undurti@hotmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27887602

Citation

Das, Undurti N.. "Combination of Aspirin With Essential Fatty Acids Is Superior to Aspirin Alone to Prevent or Ameliorate Sepsis or ARDS." Lipids in Health and Disease, vol. 15, no. 1, 2016, p. 206.
Das UN. Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. Lipids Health Dis. 2016;15(1):206.
Das, U. N. (2016). Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. Lipids in Health and Disease, 15(1), 206.
Das UN. Combination of Aspirin With Essential Fatty Acids Is Superior to Aspirin Alone to Prevent or Ameliorate Sepsis or ARDS. Lipids Health Dis. 2016 Nov 25;15(1):206. PubMed PMID: 27887602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. A1 - Das,Undurti N, Y1 - 2016/11/25/ PY - 2016/07/01/received PY - 2016/11/15/accepted PY - 2016/11/27/entrez PY - 2016/11/27/pubmed PY - 2017/4/8/medline KW - Acute respiratory distress syndrome KW - Arachidonic acid KW - Aspirin KW - Cyclo-oxygenase KW - Docosahexaenoic acid KW - Eicosapentaenoic acid KW - Essential fatty acids KW - Lipoxin A4 KW - Lipoxygenase KW - Nitric oxide KW - Protectins KW - Resolvin KW - Sepsis SP - 206 EP - 206 JF - Lipids in health and disease JO - Lipids Health Dis VL - 15 IS - 1 N2 - It has been suggested that aspirin may be of benefit in treating sepsis and ARDS in view of its ability to block cyclo-oxygenase-1 (COX-1) and COX-2 activities; inhibit nuclear factor kappa B (NF-κB); enhance the production of endothelial nitric oxide (eNO) and lipoxin A4 (LXA4). Our previous studies revealed that plasma phospholipid content of arachidonic acid (AA) and eicosapentaenoic acid (EPA) is low in patients with sepsis. This implies that beneficial actions of aspirin in sepsis and ARDS is unlikely to be obtained in view of deficiency of AA and EPA, the precursors of LXA4 and resolvins respectively that are potent anti-inflammatory compounds and enhancers of eNO generation. In view of this, I propose that a combination of aspirin and AA and EPA (and possibly, docosahexaenoic acid, DHA) is likely to be superior in the management of sepsis and ARDS compared to aspirin alone. This suggestion is supported by the recent observation that trauma patients with uncomplicated recoveries had higher resolvin pathway gene expression and lower gene expression ratios of leukotriene: resolvin pathways. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/27887602/Combination_of_aspirin_with_essential_fatty_acids_is_superior_to_aspirin_alone_to_prevent_or_ameliorate_sepsis_or_ARDS_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-016-0377-2 DB - PRIME DP - Unbound Medicine ER -