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Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials.
Pharmacol Res. 2017 01; 115:149-161.PR

Abstract

Punica granatum L. (Pomegranate) has been claimed to provide several health benefits. Pomegranate juice is a polyphenol-rich fruit juice with high antioxidant capacity. Several studies suggested that pomegranate juice can exert antiatherogenic, antioxidant, antihypertensive, and anti-inflammatory effects. Nevertheless, the potential cardioprotective benefits of pomegranate juice deserve further clinical investigation. To systematically review and meta-analyze available evidence from randomized placebo-controlled trials (RCTs) investigating the effects of pomegranate juice consumption and blood pressure (BP). A comprehensive literature search in Medline and Scopus was carried out to identify eligible RCTs. A meta-analysis of eligible studies was performed using a random-effects model. Quality assessment, sensitivity analysisand publication bias evaluations were conducted using standard methods. Quantitative data synthesis from 8 RCTs showed significant reductions in both systolic [weighed mean difference (WMD): -4.96mmHg, 95% CI: -7.67 to -2.25, p<0.001) and diastolic BP (WMD: -2.01mmHg, 95% CI: -3.71 to -0.31, p=0.021) after pomegranate juice consumption. Effects on SBP remained stable to sensitivity analyses. Pomegranate juice reduced SBP regardless of the duration (>12 wks: WMD=-4.36mmHg, 95% CI: -7.89 to -0.82, p=0.016) and <12 wks: WMD=-5.83 mmHg, 95% CI: -10.05 to -1.61, p=0.007) and dose consumed (>240cc: WMD=-3.62mmHg, 95% CI: -6.62 to -0.63, p=0.018) and <240cc: WMD=-11.01mmHg, 95% CI: -17.38 to -4.65, p=0.001, pomegranate juice per day) whereas doses >240cc provided a borderline significant effect in reducing DBP. The present meta-analysis suggests consistent benefits of pomegranate juice consumption on BP. This evidence suggests it may be prudent to include this fruit juice in a heart-healthy diet.

Authors+Show Affiliations

Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.Department of Life, Health & Environmental Sciences, University of L'Aquila, Italy.Department of Life, Health & Environmental Sciences, University of L'Aquila, Italy.Department of Medical Sciences, University of Turin, Turin, Italy.Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of Biological and Medical Sciences, Hradec Kralove, Czechia.Department of Life, Health & Environmental Sciences, University of L'Aquila, Italy. Electronic address: davide.grassi@cc.univaq.it.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

27888156

Citation

Sahebkar, Amirhossein, et al. "Effects of Pomegranate Juice On Blood Pressure: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Pharmacological Research, vol. 115, 2017, pp. 149-161.
Sahebkar A, Ferri C, Giorgini P, et al. Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017;115:149-161.
Sahebkar, A., Ferri, C., Giorgini, P., Bo, S., Nachtigal, P., & Grassi, D. (2017). Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research, 115, 149-161. https://doi.org/10.1016/j.phrs.2016.11.018
Sahebkar A, et al. Effects of Pomegranate Juice On Blood Pressure: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Pharmacol Res. 2017;115:149-161. PubMed PMID: 27888156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. AU - Sahebkar,Amirhossein, AU - Ferri,Claudio, AU - Giorgini,Paolo, AU - Bo,Simona, AU - Nachtigal,Petr, AU - Grassi,Davide, Y1 - 2016/11/23/ PY - 2016/08/12/received PY - 2016/11/07/revised PY - 2016/11/20/accepted PY - 2016/11/27/pubmed PY - 2017/12/28/medline PY - 2016/11/27/entrez KW - Antioxidants KW - Blood pressure KW - Cardiovascular risk KW - Flavonoids KW - Pomegranate SP - 149 EP - 161 JF - Pharmacological research JO - Pharmacol. Res. VL - 115 N2 - Punica granatum L. (Pomegranate) has been claimed to provide several health benefits. Pomegranate juice is a polyphenol-rich fruit juice with high antioxidant capacity. Several studies suggested that pomegranate juice can exert antiatherogenic, antioxidant, antihypertensive, and anti-inflammatory effects. Nevertheless, the potential cardioprotective benefits of pomegranate juice deserve further clinical investigation. To systematically review and meta-analyze available evidence from randomized placebo-controlled trials (RCTs) investigating the effects of pomegranate juice consumption and blood pressure (BP). A comprehensive literature search in Medline and Scopus was carried out to identify eligible RCTs. A meta-analysis of eligible studies was performed using a random-effects model. Quality assessment, sensitivity analysisand publication bias evaluations were conducted using standard methods. Quantitative data synthesis from 8 RCTs showed significant reductions in both systolic [weighed mean difference (WMD): -4.96mmHg, 95% CI: -7.67 to -2.25, p<0.001) and diastolic BP (WMD: -2.01mmHg, 95% CI: -3.71 to -0.31, p=0.021) after pomegranate juice consumption. Effects on SBP remained stable to sensitivity analyses. Pomegranate juice reduced SBP regardless of the duration (>12 wks: WMD=-4.36mmHg, 95% CI: -7.89 to -0.82, p=0.016) and <12 wks: WMD=-5.83 mmHg, 95% CI: -10.05 to -1.61, p=0.007) and dose consumed (>240cc: WMD=-3.62mmHg, 95% CI: -6.62 to -0.63, p=0.018) and <240cc: WMD=-11.01mmHg, 95% CI: -17.38 to -4.65, p=0.001, pomegranate juice per day) whereas doses >240cc provided a borderline significant effect in reducing DBP. The present meta-analysis suggests consistent benefits of pomegranate juice consumption on BP. This evidence suggests it may be prudent to include this fruit juice in a heart-healthy diet. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/27888156/Effects_of_pomegranate_juice_on_blood_pressure:_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-6618(16)30784-8 DB - PRIME DP - Unbound Medicine ER -