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[Esophageal varices: physiopathology and treatment. The role of the lower esophageal sphincter].
Ugeskr Laeger. 1989 Jun 12; 151(24):1529-31.UL

Abstract

Development of esophageal varices depends on local esophageal factors and portal gradient, vascular resistance in the azygos vein or presence of other portosystemic collaterals. Esophageal varices are found in the lamina propria of lower esophageal sphincter (LES), the pressure of which exceeds the normal portal pressure. Factors reducing LES pressure promote development of varices and enlarge these. Contraction of LES leads to reduction of the variceal and azygos flows, decrease in the pressure gradient across the varix wall and diminishes the varices. Pharmacological contraction of LES arrests the endoscopically proved bleeding from esophageal varices. Manipulation of LES pressure appears to be a genuine alternative to the current methods of treatment of the bleeding esophageal varices.

Authors

No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

dan

PubMed ID

2789444

Citation

Miskowiak, J. "[Esophageal Varices: Physiopathology and Treatment. the Role of the Lower Esophageal Sphincter]." Ugeskrift for Laeger, vol. 151, no. 24, 1989, pp. 1529-31.
Miskowiak J. [Esophageal varices: physiopathology and treatment. The role of the lower esophageal sphincter]. Ugeskr Laeger. 1989;151(24):1529-31.
Miskowiak, J. (1989). [Esophageal varices: physiopathology and treatment. The role of the lower esophageal sphincter]. Ugeskrift for Laeger, 151(24), 1529-31.
Miskowiak J. [Esophageal Varices: Physiopathology and Treatment. the Role of the Lower Esophageal Sphincter]. Ugeskr Laeger. 1989 Jun 12;151(24):1529-31. PubMed PMID: 2789444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Esophageal varices: physiopathology and treatment. The role of the lower esophageal sphincter]. A1 - Miskowiak,J, PY - 1989/6/12/pubmed PY - 1989/6/12/medline PY - 1989/6/12/entrez SP - 1529 EP - 31 JF - Ugeskrift for laeger JO - Ugeskr Laeger VL - 151 IS - 24 N2 - Development of esophageal varices depends on local esophageal factors and portal gradient, vascular resistance in the azygos vein or presence of other portosystemic collaterals. Esophageal varices are found in the lamina propria of lower esophageal sphincter (LES), the pressure of which exceeds the normal portal pressure. Factors reducing LES pressure promote development of varices and enlarge these. Contraction of LES leads to reduction of the variceal and azygos flows, decrease in the pressure gradient across the varix wall and diminishes the varices. Pharmacological contraction of LES arrests the endoscopically proved bleeding from esophageal varices. Manipulation of LES pressure appears to be a genuine alternative to the current methods of treatment of the bleeding esophageal varices. SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/2789444/[Esophageal_varices:_physiopathology_and_treatment__The_role_of_the_lower_esophageal_sphincter]_ L2 - http://www.diseaseinfosearch.org/result/2658 DB - PRIME DP - Unbound Medicine ER -
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