Tags

Type your tag names separated by a space and hit enter

CCR5-Δ32 gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in patients with type 1 diabetes.
J Diabetes Complications 2017; 31(3):615-618JD

Abstract

AIM

The aim of the study was to assess the relationship between CCR5-Δ32 polymorphism and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (T1D) in children.

METHODS

420 children with T1D aged 15.5±3.0years and 350 healthy controls were studied. Characterization of CCR5-Δ32 genotypes (rs333) was analyzed by polymerase chain reaction (PCR).

RESULTS

The allele frequency was significantly different in diabetic children as compared to the healthy controls (p<0.0001). We found negative association between T1D and Δ32 allele (OR=0.383; 95% CI=0.268-0.549). Besides, we observed alterations in the frequencies of CCR5-Δ32 genotypes due to celiac and autoimmune thyroid diseases. The risk of celiac disease for patient carriers of the 32-bp deletion was more than threefold higher than for noncarriers (OR=3.490; 95% CI=1.357-8.859; p=0.009). Similar results were obtained in the case of autoimmune thyroiditis. The risk of autoimmune thyroiditis for patient carriers of the 32-bp deletion was also more than threefold higher than for noncarriers (OR=3.466; 95% CI=1.754-6.849; p=0.0004).

CONCLUSIONS

The findings of our studies suggest that the CCR5-Δ32 polymorphism is associated with type 1 diabetes mellitus and the Δ32 allele increases the risk of celiac disease and autoimmune thyroid disorders in patients with T1D.

Authors+Show Affiliations

Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk. Electronic address: bartosz@gumed.edu.pl.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk.Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211 Gdańsk.Chair & Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk.Chair & Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27894748

Citation

Słomiński, Bartosz, et al. "CCR5-Δ32 Gene Polymorphism Is Related to Celiac Disease and Autoimmune Thyroiditis Coincidence in Patients With Type 1 Diabetes." Journal of Diabetes and Its Complications, vol. 31, no. 3, 2017, pp. 615-618.
Słomiński B, Ławrynowicz U, Myśliwska J, et al. CCR5-Δ32 gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in patients with type 1 diabetes. J Diabetes Complicat. 2017;31(3):615-618.
Słomiński, B., Ławrynowicz, U., Myśliwska, J., Ryba-Stanisławowska, M., Skrzypkowska, M., Myśliwiec, M., & Brandt, A. (2017). CCR5-Δ32 gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in patients with type 1 diabetes. Journal of Diabetes and Its Complications, 31(3), pp. 615-618. doi:10.1016/j.jdiacomp.2016.10.031.
Słomiński B, et al. CCR5-Δ32 Gene Polymorphism Is Related to Celiac Disease and Autoimmune Thyroiditis Coincidence in Patients With Type 1 Diabetes. J Diabetes Complicat. 2017;31(3):615-618. PubMed PMID: 27894748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CCR5-Δ32 gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in patients with type 1 diabetes. AU - Słomiński,Bartosz, AU - Ławrynowicz,Urszula, AU - Myśliwska,Jolanta, AU - Ryba-Stanisławowska,Monika, AU - Skrzypkowska,Maria, AU - Myśliwiec,Małgorzata, AU - Brandt,Agnieszka, Y1 - 2016/11/03/ PY - 2016/06/21/received PY - 2016/10/03/revised PY - 2016/10/28/accepted PY - 2016/11/30/pubmed PY - 2018/3/7/medline PY - 2016/11/30/entrez KW - Autoimmune thyroiditis KW - CCR5-Δ32 polymorphism KW - Celiac disease KW - Children KW - Type 1 diabetes mellitus SP - 615 EP - 618 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 31 IS - 3 N2 - AIM: The aim of the study was to assess the relationship between CCR5-Δ32 polymorphism and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (T1D) in children. METHODS: 420 children with T1D aged 15.5±3.0years and 350 healthy controls were studied. Characterization of CCR5-Δ32 genotypes (rs333) was analyzed by polymerase chain reaction (PCR). RESULTS: The allele frequency was significantly different in diabetic children as compared to the healthy controls (p<0.0001). We found negative association between T1D and Δ32 allele (OR=0.383; 95% CI=0.268-0.549). Besides, we observed alterations in the frequencies of CCR5-Δ32 genotypes due to celiac and autoimmune thyroid diseases. The risk of celiac disease for patient carriers of the 32-bp deletion was more than threefold higher than for noncarriers (OR=3.490; 95% CI=1.357-8.859; p=0.009). Similar results were obtained in the case of autoimmune thyroiditis. The risk of autoimmune thyroiditis for patient carriers of the 32-bp deletion was also more than threefold higher than for noncarriers (OR=3.466; 95% CI=1.754-6.849; p=0.0004). CONCLUSIONS: The findings of our studies suggest that the CCR5-Δ32 polymorphism is associated with type 1 diabetes mellitus and the Δ32 allele increases the risk of celiac disease and autoimmune thyroid disorders in patients with T1D. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/27894748/CCR5_Δ32_gene_polymorphism_is_related_to_celiac_disease_and_autoimmune_thyroiditis_coincidence_in_patients_with_type_1_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(16)30787-5 DB - PRIME DP - Unbound Medicine ER -