Tags

Type your tag names separated by a space and hit enter

Abnormalities of brain neural circuits related to obesity: A Diffusion Tensor Imaging study.
Magn Reson Imaging. 2017 Apr; 37:116-121.MR

Abstract

PURPOSE

Increased Body-Mass-Index (BMI) has been associated with brain atrophy in both gray and white matter structures. However, little is known concerning the integrity of white matter tracts in obesity. The purpose of the study was to evaluate the pattern of changes in white matter microstructure in human adiposity.

MATERIAL AND METHODS

The study included 268 participants (52 obese, 96 overweight and 120 normal-weight) that were retrospectively evaluated by Diffusion Tensor Imaging. The fractional anisotropy, axial, radial and mean diffusivity values were compared between the above groups using Tract Based Spatial Statistics.

RESULTS

The analysis revealed that the increased BMI was related with decreased fractional anisotropy in several white matter regions including the anterior and posterior thalamic radiation, the inferior fronto-occipital fasciculus, the inferior and superior longitudinal fasciculus, the corpus callosum (callosal body and forceps minor), the uncinate fasciculus, the internal capsule, the corticospinal tract and the cingulum (cingulate gyrus and hippocampus).

CONCLUSIONS

Anisotropic diffusion of anatomic regions governing important brain circuits such as reward seeking inhibition, motivation/drive and learning/conditioning decreases with increasing BMI.

Authors+Show Affiliations

Department of Radiology, Medical School University of Ioannina, Ioannina 45110, Greece.Department of Medical Physics, Medical School University of Ioannina, Ioannina 45110, Greece.Department of Radiology, Medical School University of Ioannina, Ioannina 45110, Greece.Department of Neurosurgery, Medical School University of Ioannina, Ioannina 45110, Greece. Electronic address: alexiougrg@yahoo.gr.Department of Physiology, Medical School University of Ioannina, Ioannina 45110, Greece.Department of Radiology, Medical School University of Ioannina, Ioannina 45110, Greece.Department of Radiology, Medical School University of Ioannina, Ioannina 45110, Greece.Department of Physiology, Medical School University of Ioannina, Ioannina 45110, Greece.Department of Radiology, Medical School University of Ioannina, Ioannina 45110, Greece.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27899333

Citation

Papageorgiou, Ioannis, et al. "Abnormalities of Brain Neural Circuits Related to Obesity: a Diffusion Tensor Imaging Study." Magnetic Resonance Imaging, vol. 37, 2017, pp. 116-121.
Papageorgiou I, Astrakas LG, Xydis V, et al. Abnormalities of brain neural circuits related to obesity: A Diffusion Tensor Imaging study. Magn Reson Imaging. 2017;37:116-121.
Papageorgiou, I., Astrakas, L. G., Xydis, V., Alexiou, G. A., Bargiotas, P., Tzarouchi, L., Zikou, A. K., Kiortsis, D. N., & Argyropoulou, M. I. (2017). Abnormalities of brain neural circuits related to obesity: A Diffusion Tensor Imaging study. Magnetic Resonance Imaging, 37, 116-121. https://doi.org/10.1016/j.mri.2016.11.018
Papageorgiou I, et al. Abnormalities of Brain Neural Circuits Related to Obesity: a Diffusion Tensor Imaging Study. Magn Reson Imaging. 2017;37:116-121. PubMed PMID: 27899333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormalities of brain neural circuits related to obesity: A Diffusion Tensor Imaging study. AU - Papageorgiou,Ioannis, AU - Astrakas,Loukas G, AU - Xydis,Vassileios, AU - Alexiou,George A, AU - Bargiotas,Panagiotis, AU - Tzarouchi,Loukia, AU - Zikou,Anastasia K, AU - Kiortsis,Dimitrios N, AU - Argyropoulou,Maria I, Y1 - 2016/11/27/ PY - 2016/04/25/received PY - 2016/11/24/revised PY - 2016/11/25/accepted PY - 2016/12/3/pubmed PY - 2017/8/11/medline PY - 2016/12/1/entrez KW - Body-Mass-Index KW - Food addiction KW - Fractional anisotropy KW - Reward system SP - 116 EP - 121 JF - Magnetic resonance imaging JO - Magn Reson Imaging VL - 37 N2 - PURPOSE: Increased Body-Mass-Index (BMI) has been associated with brain atrophy in both gray and white matter structures. However, little is known concerning the integrity of white matter tracts in obesity. The purpose of the study was to evaluate the pattern of changes in white matter microstructure in human adiposity. MATERIAL AND METHODS: The study included 268 participants (52 obese, 96 overweight and 120 normal-weight) that were retrospectively evaluated by Diffusion Tensor Imaging. The fractional anisotropy, axial, radial and mean diffusivity values were compared between the above groups using Tract Based Spatial Statistics. RESULTS: The analysis revealed that the increased BMI was related with decreased fractional anisotropy in several white matter regions including the anterior and posterior thalamic radiation, the inferior fronto-occipital fasciculus, the inferior and superior longitudinal fasciculus, the corpus callosum (callosal body and forceps minor), the uncinate fasciculus, the internal capsule, the corticospinal tract and the cingulum (cingulate gyrus and hippocampus). CONCLUSIONS: Anisotropic diffusion of anatomic regions governing important brain circuits such as reward seeking inhibition, motivation/drive and learning/conditioning decreases with increasing BMI. SN - 1873-5894 UR - https://www.unboundmedicine.com/medline/citation/27899333/Abnormalities_of_brain_neural_circuits_related_to_obesity:_A_Diffusion_Tensor_Imaging_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0730-725X(16)30231-4 DB - PRIME DP - Unbound Medicine ER -