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Intake of key micronutrients and food groups in patients with late-stage age-related macular degeneration compared with age-sex-matched controls.

Abstract

BACKGROUND

Knowledge of the risk factor profile of patients presenting with late-stage age-related macular degeneration (AMD) could help identify the most frequent modifiable AMD precursors among people who are referred for treatment. We aimed to assess dietary behaviours by comparing adjusted mean intakes of micronutrients and major food groups (fruits, vegetables, fish) among patients with AMD and a sample of age-sex-matched controls.

METHODS

Cross-sectional analysis of 480 late AMD cases and 518 population-based age-sex-matched controls with no AMD signs. AMD cases (aged 60+ years) were those presenting for treatment to a hospital eye clinic in Sydney, Australia, during 2012-2015. The comparator group were obtained from a cohort study (Blue Mountains Eye Study; Sydney, Australia) during 2002-2009. Dietary intake was assessed using a semiquantitative food-frequency questionnaire. AMD lesions were assessed from retinal photographs.

RESULTS

After multivariable adjustment, patients with late-stage AMD compared with controls had significantly lower intakes of vitamin E (7.4 vs 9.8 mg/day; p<0.0001), beta-carotene (6232 vs 7738 μg/day; p<0.0001), vitamin C (161 vs 184 mg/day; p=0.0002) and folate (498.3 vs 602 μg/day; p<0.0001); but had higher intakes of zinc (13.0 vs 11.9 mg/day; p<0.0001). A significantly lower proportion of patients with late AMD met the recommended intake of vegetables than controls: 52.9% versus 64.5%; p=0.0002.

CONCLUSIONS

This study showed significant differences in intakes of vitamins C and E, beta-carotene, folate and vegetables between patients with late-stage AMD and healthy controls, and thus has provided a better understanding of the nutritional intake of patients presenting with advanced AMD.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Centre for Vision Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.

    ,

    Centre for Vision Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.

    ,

    Faculty of Social Sciences, School of Health and Society, University of Wollongong, Sydney, New South Wales, Australia.

    ,

    Centre for Vision Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.

    ,

    Centre for Vision Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.

    Centre for Vision Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.

    Source

    The British journal of ophthalmology 101:8 2017 08 pg 1027-1031

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Ascorbic Acid
    Case-Control Studies
    Cross-Sectional Studies
    Diet
    Fish Products
    Food
    Fruit
    Humans
    Macular Degeneration
    Male
    Micronutrients
    Middle Aged
    Vegetables
    Vitamin E
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    27899367

    Citation

    Gopinath, Bamini, et al. "Intake of Key Micronutrients and Food Groups in Patients With Late-stage Age-related Macular Degeneration Compared With Age-sex-matched Controls." The British Journal of Ophthalmology, vol. 101, no. 8, 2017, pp. 1027-1031.
    Gopinath B, Liew G, Russell J, et al. Intake of key micronutrients and food groups in patients with late-stage age-related macular degeneration compared with age-sex-matched controls. Br J Ophthalmol. 2017;101(8):1027-1031.
    Gopinath, B., Liew, G., Russell, J., Cosatto, V., Burlutsky, G., & Mitchell, P. (2017). Intake of key micronutrients and food groups in patients with late-stage age-related macular degeneration compared with age-sex-matched controls. The British Journal of Ophthalmology, 101(8), pp. 1027-1031. doi:10.1136/bjophthalmol-2016-309490.
    Gopinath B, et al. Intake of Key Micronutrients and Food Groups in Patients With Late-stage Age-related Macular Degeneration Compared With Age-sex-matched Controls. Br J Ophthalmol. 2017;101(8):1027-1031. PubMed PMID: 27899367.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of key micronutrients and food groups in patients with late-stage age-related macular degeneration compared with age-sex-matched controls. AU - Gopinath,Bamini, AU - Liew,Gerald, AU - Russell,Joanna, AU - Cosatto,Victoria, AU - Burlutsky,George, AU - Mitchell,Paul, Y1 - 2016/11/29/ PY - 2016/08/09/received PY - 2016/11/14/revised PY - 2016/11/16/accepted PY - 2016/12/3/pubmed PY - 2017/7/27/medline PY - 2016/12/1/entrez KW - Epidemiology KW - Macula KW - Public health SP - 1027 EP - 1031 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 101 IS - 8 N2 - BACKGROUND: Knowledge of the risk factor profile of patients presenting with late-stage age-related macular degeneration (AMD) could help identify the most frequent modifiable AMD precursors among people who are referred for treatment. We aimed to assess dietary behaviours by comparing adjusted mean intakes of micronutrients and major food groups (fruits, vegetables, fish) among patients with AMD and a sample of age-sex-matched controls. METHODS: Cross-sectional analysis of 480 late AMD cases and 518 population-based age-sex-matched controls with no AMD signs. AMD cases (aged 60+ years) were those presenting for treatment to a hospital eye clinic in Sydney, Australia, during 2012-2015. The comparator group were obtained from a cohort study (Blue Mountains Eye Study; Sydney, Australia) during 2002-2009. Dietary intake was assessed using a semiquantitative food-frequency questionnaire. AMD lesions were assessed from retinal photographs. RESULTS: After multivariable adjustment, patients with late-stage AMD compared with controls had significantly lower intakes of vitamin E (7.4 vs 9.8 mg/day; p<0.0001), beta-carotene (6232 vs 7738 μg/day; p<0.0001), vitamin C (161 vs 184 mg/day; p=0.0002) and folate (498.3 vs 602 μg/day; p<0.0001); but had higher intakes of zinc (13.0 vs 11.9 mg/day; p<0.0001). A significantly lower proportion of patients with late AMD met the recommended intake of vegetables than controls: 52.9% versus 64.5%; p=0.0002. CONCLUSIONS: This study showed significant differences in intakes of vitamins C and E, beta-carotene, folate and vegetables between patients with late-stage AMD and healthy controls, and thus has provided a better understanding of the nutritional intake of patients presenting with advanced AMD. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/27899367/Intake_of_key_micronutrients_and_food_groups_in_patients_with_late_stage_age_related_macular_degeneration_compared_with_age_sex_matched_controls_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=27899367 DB - PRIME DP - Unbound Medicine ER -