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Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India.
J Med Microbiol. 2016 Dec; 65(12):1536-1539.JM

Abstract

Decreased ciprofloxacin susceptibility (DCS) and multidrug resistance in typhoidal Salmonella isolates in areas of endemicity are significant therapeutic problems. Guidelines for azithromycin disc diffusion and MIC interpretive criteria for Salmonella enterica serovar Typhi were published recently by the Clinical and Laboratory Standards Institute in 2015. We investigated the antimicrobial susceptibility pattern of azithromycin in 100 isolates of Salmonella Typhi (n=80), Paratyphi A (n=18) and B (n=2) recovered from bloodstream infections from January 2013 to December 2015. Zone sizes were extrapolated against MIC values, and a scatter plot was constructed. The azithromycin MICs by Etest ranged from 2 to 16 µg ml-1, while the disc diffusion diameters were from 13 to 22 mm. We observed that the margin of the zone of inhibition around the azithromycin disc may not be very clear and therefore difficult to interpret and that there was wide variation in the zone sizes for the same MIC value in both serovars. DCS was observed in 85 % of Salmonella Typhi recovered (68/80) and in 15/18 (83.3 %) Paratyphi A isolates. Judicious use of azithromycin is advocated as an alternative oral agent in endemic areas where DCS is common.

Authors+Show Affiliations

Department of Microbiology, Division Bacteriology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow 226014, India.Department of Microbiology, Division Bacteriology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow 226014, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27902389

Citation

Misra, Richa, and Kashi Nath Prasad. "Antimicrobial Susceptibility to Azithromycin Among Salmonella Enterica Typhi and Paratyphi a Isolates From India." Journal of Medical Microbiology, vol. 65, no. 12, 2016, pp. 1536-1539.
Misra R, Prasad KN. Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India. J Med Microbiol. 2016;65(12):1536-1539.
Misra, R., & Prasad, K. N. (2016). Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India. Journal of Medical Microbiology, 65(12), 1536-1539. https://doi.org/10.1099/jmm.0.000390
Misra R, Prasad KN. Antimicrobial Susceptibility to Azithromycin Among Salmonella Enterica Typhi and Paratyphi a Isolates From India. J Med Microbiol. 2016;65(12):1536-1539. PubMed PMID: 27902389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India. AU - Misra,Richa, AU - Prasad,Kashi Nath, Y1 - 2016/11/10/ PY - 2016/12/3/pubmed PY - 2017/1/28/medline PY - 2016/12/1/entrez SP - 1536 EP - 1539 JF - Journal of medical microbiology JO - J Med Microbiol VL - 65 IS - 12 N2 - Decreased ciprofloxacin susceptibility (DCS) and multidrug resistance in typhoidal Salmonella isolates in areas of endemicity are significant therapeutic problems. Guidelines for azithromycin disc diffusion and MIC interpretive criteria for Salmonella enterica serovar Typhi were published recently by the Clinical and Laboratory Standards Institute in 2015. We investigated the antimicrobial susceptibility pattern of azithromycin in 100 isolates of Salmonella Typhi (n=80), Paratyphi A (n=18) and B (n=2) recovered from bloodstream infections from January 2013 to December 2015. Zone sizes were extrapolated against MIC values, and a scatter plot was constructed. The azithromycin MICs by Etest ranged from 2 to 16 µg ml-1, while the disc diffusion diameters were from 13 to 22 mm. We observed that the margin of the zone of inhibition around the azithromycin disc may not be very clear and therefore difficult to interpret and that there was wide variation in the zone sizes for the same MIC value in both serovars. DCS was observed in 85 % of Salmonella Typhi recovered (68/80) and in 15/18 (83.3 %) Paratyphi A isolates. Judicious use of azithromycin is advocated as an alternative oral agent in endemic areas where DCS is common. SN - 1473-5644 UR - https://www.unboundmedicine.com/medline/citation/27902389/Antimicrobial_susceptibility_to_azithromycin_among_Salmonella_enterica_Typhi_and_Paratyphi_A_isolates_from_India_ DB - PRIME DP - Unbound Medicine ER -