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Neurexin regulates nighttime sleep by modulating synaptic transmission.
Sci Rep. 2016 12 01; 6:38246.SR

Abstract

Neurexins are cell adhesion molecules involved in synaptic formation and synaptic transmission. Mutations in neurexin genes are linked to autism spectrum disorders (ASDs), which are frequently associated with sleep problems. However, the role of neurexin-mediated synaptic transmission in sleep regulation is unclear. Here, we show that lack of the Drosophila α-neurexin homolog significantly reduces the quantity and quality of nighttime sleep and impairs sleep homeostasis. We report that neurexin expression in Drosophila mushroom body (MB) αβ neurons is essential for nighttime sleep. We demonstrate that reduced nighttime sleep in neurexin mutants is due to impaired αβ neuronal output, and show that neurexin functionally couples calcium channels (Cac) to regulate synaptic transmission. Finally, we determine that αβ surface (αβs) neurons release both acetylcholine and short neuropeptide F (sNPF), whereas αβ core (αβc) neurons release sNPF to promote nighttime sleep. Our findings reveal that neurexin regulates nighttime sleep by mediating the synaptic transmission of αβ neurons. This study elucidates the role of synaptic transmission in sleep regulation, and might offer insights into the mechanism of sleep disturbances in patients with autism disorders.

Authors+Show Affiliations

Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China.Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Diseases, Southeast University, Nanjing 210096, China. Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, JS 226001, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27905548

Citation

Tong, Huawei, et al. "Neurexin Regulates Nighttime Sleep By Modulating Synaptic Transmission." Scientific Reports, vol. 6, 2016, p. 38246.
Tong H, Li Q, Zhang ZC, et al. Neurexin regulates nighttime sleep by modulating synaptic transmission. Sci Rep. 2016;6:38246.
Tong, H., Li, Q., Zhang, Z. C., Li, Y., & Han, J. (2016). Neurexin regulates nighttime sleep by modulating synaptic transmission. Scientific Reports, 6, 38246. https://doi.org/10.1038/srep38246
Tong H, et al. Neurexin Regulates Nighttime Sleep By Modulating Synaptic Transmission. Sci Rep. 2016 12 1;6:38246. PubMed PMID: 27905548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurexin regulates nighttime sleep by modulating synaptic transmission. AU - Tong,Huawei, AU - Li,Qian, AU - Zhang,Zi Chao, AU - Li,Yi, AU - Han,Junhai, Y1 - 2016/12/01/ PY - 2016/08/10/received PY - 2016/11/07/accepted PY - 2016/12/2/entrez PY - 2016/12/3/pubmed PY - 2018/5/31/medline SP - 38246 EP - 38246 JF - Scientific reports JO - Sci Rep VL - 6 N2 - Neurexins are cell adhesion molecules involved in synaptic formation and synaptic transmission. Mutations in neurexin genes are linked to autism spectrum disorders (ASDs), which are frequently associated with sleep problems. However, the role of neurexin-mediated synaptic transmission in sleep regulation is unclear. Here, we show that lack of the Drosophila α-neurexin homolog significantly reduces the quantity and quality of nighttime sleep and impairs sleep homeostasis. We report that neurexin expression in Drosophila mushroom body (MB) αβ neurons is essential for nighttime sleep. We demonstrate that reduced nighttime sleep in neurexin mutants is due to impaired αβ neuronal output, and show that neurexin functionally couples calcium channels (Cac) to regulate synaptic transmission. Finally, we determine that αβ surface (αβs) neurons release both acetylcholine and short neuropeptide F (sNPF), whereas αβ core (αβc) neurons release sNPF to promote nighttime sleep. Our findings reveal that neurexin regulates nighttime sleep by mediating the synaptic transmission of αβ neurons. This study elucidates the role of synaptic transmission in sleep regulation, and might offer insights into the mechanism of sleep disturbances in patients with autism disorders. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/27905548/Neurexin_regulates_nighttime_sleep_by_modulating_synaptic_transmission_ L2 - http://dx.doi.org/10.1038/srep38246 DB - PRIME DP - Unbound Medicine ER -