Tags

Type your tag names separated by a space and hit enter

Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study.
PLoS One. 2016; 11(12):e0167331.Plos

Abstract

BACKGROUND

Despite significant advances in quantitative neuroimaging, the diagnosis of ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis. The objective of this study is to develop a robust, disease-specific, multimodal classification protocol and validate its diagnostic accuracy in independent, early-stage and follow-up data sets.

METHODS

147 participants (81 ALS patients and 66 healthy controls) were divided into a training sample and a validation sample. Patients in the validation sample underwent follow-up imaging longitudinally. After removing age-related variability, indices of grey and white matter integrity in ALS-specific pathognomonic brain regions were included in a cross-validated binary logistic regression model to determine the probability of individual scans indicating ALS. The following anatomical regions were assessed for diagnostic classification: average grey matter density of the left and right precentral gyrus, the average fractional anisotropy and radial diffusivity of the left and right superior corona radiata, inferior corona radiata, internal capsule, mesencephalic crus of the cerebral peduncles, pontine segment of the corticospinal tract, and the average diffusivity values of the genu, corpus and splenium of the corpus callosum.

RESULTS

Using a 50% probability cut-off value of suffering from ALS, the model was able to discriminate ALS patients and HC with good sensitivity (80.0%) and moderate accuracy (70.0%) in the training sample and superior sensitivity (85.7%) and accuracy (78.4%) in the independent validation sample.

CONCLUSIONS

This diagnostic classification study endeavours to advance ALS biomarker research towards pragmatic clinical applications by providing an approach of automated individual-data interpretation based on group-level observations.

Authors+Show Affiliations

Quantitative Neuroimaging Group, Academic Unit of Neurology, Biomedical Sciences Institute, Trinity College Dublin, Ireland.Quantitative Neuroimaging Group, Academic Unit of Neurology, Biomedical Sciences Institute, Trinity College Dublin, Ireland.Quantitative Neuroimaging Group, Academic Unit of Neurology, Biomedical Sciences Institute, Trinity College Dublin, Ireland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27907080

Citation

Schuster, Christina, et al. "Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: a Quantitative Disease-State Classification Study." PloS One, vol. 11, no. 12, 2016, pp. e0167331.
Schuster C, Hardiman O, Bede P. Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study. PLoS ONE. 2016;11(12):e0167331.
Schuster, C., Hardiman, O., & Bede, P. (2016). Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study. PloS One, 11(12), e0167331. https://doi.org/10.1371/journal.pone.0167331
Schuster C, Hardiman O, Bede P. Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: a Quantitative Disease-State Classification Study. PLoS ONE. 2016;11(12):e0167331. PubMed PMID: 27907080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study. AU - Schuster,Christina, AU - Hardiman,Orla, AU - Bede,Peter, Y1 - 2016/12/01/ PY - 2016/06/07/received PY - 2016/11/12/accepted PY - 2016/12/2/entrez PY - 2016/12/3/pubmed PY - 2017/7/1/medline SP - e0167331 EP - e0167331 JF - PloS one JO - PLoS ONE VL - 11 IS - 12 N2 - BACKGROUND: Despite significant advances in quantitative neuroimaging, the diagnosis of ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis. The objective of this study is to develop a robust, disease-specific, multimodal classification protocol and validate its diagnostic accuracy in independent, early-stage and follow-up data sets. METHODS: 147 participants (81 ALS patients and 66 healthy controls) were divided into a training sample and a validation sample. Patients in the validation sample underwent follow-up imaging longitudinally. After removing age-related variability, indices of grey and white matter integrity in ALS-specific pathognomonic brain regions were included in a cross-validated binary logistic regression model to determine the probability of individual scans indicating ALS. The following anatomical regions were assessed for diagnostic classification: average grey matter density of the left and right precentral gyrus, the average fractional anisotropy and radial diffusivity of the left and right superior corona radiata, inferior corona radiata, internal capsule, mesencephalic crus of the cerebral peduncles, pontine segment of the corticospinal tract, and the average diffusivity values of the genu, corpus and splenium of the corpus callosum. RESULTS: Using a 50% probability cut-off value of suffering from ALS, the model was able to discriminate ALS patients and HC with good sensitivity (80.0%) and moderate accuracy (70.0%) in the training sample and superior sensitivity (85.7%) and accuracy (78.4%) in the independent validation sample. CONCLUSIONS: This diagnostic classification study endeavours to advance ALS biomarker research towards pragmatic clinical applications by providing an approach of automated individual-data interpretation based on group-level observations. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27907080/Development_of_an_Automated_MRI_Based_Diagnostic_Protocol_for_Amyotrophic_Lateral_Sclerosis_Using_Disease_Specific_Pathognomonic_Features:_A_Quantitative_Disease_State_Classification_Study_ L2 - http://dx.plos.org/10.1371/journal.pone.0167331 DB - PRIME DP - Unbound Medicine ER -