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Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer.
Cancer Res. 1989 Nov 01; 49(21):6144-8.CR

Abstract

To examine the association between serum nutrients and the development of bladder cancer we measured selenium, alpha-tocopherol, lycopene, beta-carotene, retinol, and retinol-binding protein in serum collected from 25,802 persons in Washington County, MD, in 1974. Serum samples were kept frozen at -70 degrees C. In the subsequent 12-year period, 35 cases of bladder cancer developed among participants. Comparisons of serum levels in 1974 among cases and two matched controls for each case showed that selenium was significantly lower among cases than controls (P = 0.03), lycopene was lower among cases at a borderline level of significance (P = 0.07), and alpha-tocopherol was nonsignificantly lower (P = 0.13). For selenium there was a nearly linear increase in risk with decreasing serum levels (P = 0.03). When examined by tertiles, the odds ratio associated with the lowest tertile of selenium compared to the highest tertile was 2.06. Serum levels of retinol, retinol-binding protein, and beta-carotene were similar among cases and controls. These results support a role for selenium in the prevention of bladder cancer.

Authors+Show Affiliations

Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2790827

Citation

Helzlsouer, K J., et al. "Selenium, Lycopene, Alpha-tocopherol, Beta-carotene, Retinol, and Subsequent Bladder Cancer." Cancer Research, vol. 49, no. 21, 1989, pp. 6144-8.
Helzlsouer KJ, Comstock GW, Morris JS. Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Res. 1989;49(21):6144-8.
Helzlsouer, K. J., Comstock, G. W., & Morris, J. S. (1989). Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. Cancer Research, 49(21), 6144-8.
Helzlsouer KJ, Comstock GW, Morris JS. Selenium, Lycopene, Alpha-tocopherol, Beta-carotene, Retinol, and Subsequent Bladder Cancer. Cancer Res. 1989 Nov 1;49(21):6144-8. PubMed PMID: 2790827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium, lycopene, alpha-tocopherol, beta-carotene, retinol, and subsequent bladder cancer. AU - Helzlsouer,K J, AU - Comstock,G W, AU - Morris,J S, PY - 1989/11/1/pubmed PY - 1989/11/1/medline PY - 1989/11/1/entrez SP - 6144 EP - 8 JF - Cancer research JO - Cancer Res. VL - 49 IS - 21 N2 - To examine the association between serum nutrients and the development of bladder cancer we measured selenium, alpha-tocopherol, lycopene, beta-carotene, retinol, and retinol-binding protein in serum collected from 25,802 persons in Washington County, MD, in 1974. Serum samples were kept frozen at -70 degrees C. In the subsequent 12-year period, 35 cases of bladder cancer developed among participants. Comparisons of serum levels in 1974 among cases and two matched controls for each case showed that selenium was significantly lower among cases than controls (P = 0.03), lycopene was lower among cases at a borderline level of significance (P = 0.07), and alpha-tocopherol was nonsignificantly lower (P = 0.13). For selenium there was a nearly linear increase in risk with decreasing serum levels (P = 0.03). When examined by tertiles, the odds ratio associated with the lowest tertile of selenium compared to the highest tertile was 2.06. Serum levels of retinol, retinol-binding protein, and beta-carotene were similar among cases and controls. These results support a role for selenium in the prevention of bladder cancer. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/2790827/Selenium_lycopene_alpha_tocopherol_beta_carotene_retinol_and_subsequent_bladder_cancer_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=2790827 DB - PRIME DP - Unbound Medicine ER -