Citation
Chung, Lorinda, et al. "Utility of B-type Natriuretic Peptides in the Assessment of Patients With Systemic Sclerosis-associated Pulmonary Hypertension in the PHAROS Registry." Clinical and Experimental Rheumatology, vol. 35 Suppl 106, no. 4, 2017, pp. 106-113.
Chung L, Fairchild RM, Furst DE, et al. Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry. Clin Exp Rheumatol. 2017;35 Suppl 106(4):106-113.
Chung, L., Fairchild, R. M., Furst, D. E., Li, S., Alkassab, F., Bolster, M. B., Csuka, M. E., Derk, C. T., Domsic, R. T., Fischer, A., Frech, T. M., Gomberg-Maitland, M., Gordon, J. K., Hinchcliff, M., Hsu, V., Hummers, L. K., Khanna, D., Medsger, T. A. J., Molitor, J. A., ... Zamanian, R. T. (2017). Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry. Clinical and Experimental Rheumatology, 35 Suppl 106(4), 106-113.
Chung L, et al. Utility of B-type Natriuretic Peptides in the Assessment of Patients With Systemic Sclerosis-associated Pulmonary Hypertension in the PHAROS Registry. Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):106-113. PubMed PMID: 27908301.
TY - JOUR
T1 - Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry.
AU - Chung,Lorinda,
AU - Fairchild,Robert M,
AU - Furst,Daniel E,
AU - Li,Shufeng,
AU - Alkassab,Firas,
AU - Bolster,Marcy B,
AU - Csuka,Mary Ellen,
AU - Derk,Chris T,
AU - Domsic,Robyn T,
AU - Fischer,Aryeh,
AU - Frech,Tracy M,
AU - Gomberg-Maitland,Mardi,
AU - Gordon,Jessica K,
AU - Hinchcliff,Monique,
AU - Hsu,Vivien,
AU - Hummers,Laura K,
AU - Khanna,Dinesh,
AU - Medsger,Thomas A Jr,
AU - Molitor,Jerry A,
AU - Preston,Ivana R,
AU - Schiopu,Elena,
AU - Shapiro,Lee,
AU - Hant,Faye,
AU - Silver,Richard,
AU - Simms,Robert,
AU - Varga,John,
AU - Steen,Virginia D,
AU - Zamanian,Roham T,
Y1 - 2016/11/10/
PY - 2016/03/01/received
PY - 2016/09/28/accepted
PY - 2016/12/3/pubmed
PY - 2017/12/22/medline
PY - 2016/12/3/entrez
SP - 106
EP - 113
JF - Clinical and experimental rheumatology
JO - Clin Exp Rheumatol
VL - 35 Suppl 106
IS - 4
N2 - OBJECTIVES: To assess the utility of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) in detecting and monitoring pulmonary hypertension (PH) in systemic sclerosis (SSc). METHODS: PHAROS is a multicenter prospective cohort of SSc patients at high risk for developing pulmonary arterial hypertension (SSc-AR-PAH) or with a definitive diagnosis of SSc-PH. We evaluated 1) the sensitivity and specificity of BNP≥64 and NT-proBNP≥210 pg/mL for the detection of SSc-PAH and/ or SSc-PH in the SSc-AR-PAH population; 2) baseline and longitudinal BNP and NT-proBNP levels as predictors of progression to SSc-PAH and/or SSc-PH; 3) baseline BNP≥180, NT-proBNP≥553 pg/mL, and longitudinal changes in BNP and NT-proBNP as predictors of mortality in SSc-PH diagnosed patients. RESULTS: 172 SSc-PH and 157 SSc-AR- PAH patients had natriuretic peptide levels available. Median BNP and NT-proBNP were significantly higher in the SSc-PH versus SSc-AR-PAH group. The sensitivity and specificity for SSc-PAH detection using baseline BNP≥64 pg/mL was 71% and 59%; and for NT-proBNP≥210 pg/mL, 73% and 78%. NT-proBNP showed stronger correlations with haemodynamic indicators of right ventricular dysfunction than BNP. Baseline creatinine, RVSP > 40 mmHg, and FVC%:DLco% ratio ≥1.8 were associated with progression from SSc-AR-PAH to SSc-PH but no association with individual or combined baseline BNP and NT-proBNP levels was observed. Baseline and follow-up BNP or NT-proBNP levels were not predictive of death, however, a composite BNP/NT-proBNP group predicted mortality (HR 3.81 (2.08-6.99), p<.0001). CONCLUSIONS: NT-proBNP may be more useful than BNP in the detection and monitoring of PAH in SSc patients, but additional studies are necessary.
SN - 0392-856X
UR - https://www.unboundmedicine.com/medline/citation/27908301/Utility_of_B_type_natriuretic_peptides_in_the_assessment_of_patients_with_systemic_sclerosis_associated_pulmonary_hypertension_in_the_PHAROS_registry_
L2 - http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=27908301
DB - PRIME
DP - Unbound Medicine
ER -