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Association between fat mass and bone mineral density among Brazilian women differs by menopausal status: The Pró-Saúde Study.
Nutrition 2017; 33:14-19N

Abstract

OBJECTIVE

The aim of this study was to investigate the association between bone mineral density (BMD) and fat mass (FM) in a multiethnic population of Brazilian women and to evaluate the influence of total body mass and lean mass on this association.

METHODS

This was a cross-sectional study nested within the Pro-Saúde Study, a prospective cohort of university civil servants in Rio de Janeiro. Participants were pre- (n = 100) and postmenopausal (n = 166) women. Total fat, lean mass, and BMD of total body, lumbar spine, and femoral neck were measured using dual energy x-ray absorptiometry. The association of BMD with FM was investigated after adjustment for total body mass (model 1) and lean mass (model 2) and potential confounding variables using multivariate linear regression models.

RESULTS

In model 1, FM was inversely associated with BMD for total body (B = -0.010; P < 0.01) and for femoral neck (B = -0.009 P < 0.05) in premenopausal women. No association between FM and BMD was observed in postmenopausal women. Model 2 yielded direct associations between FM and BMD (total and specific sites; B = 0.003-0.008; P < 0.01) in postmenopausal women only.

CONCLUSIONS

Independently of the adjustment used, the results of the present study suggest the absence of an inverse association between FM and BMD in postmenopausal women. Additionally, when adjusted for lean mass, a direct association between FM and bone mass can be observed, suggesting that for postmenopausal women being slightly obese does not confer excessive risk for bone loss and may even result in a bone density advantage.

Authors+Show Affiliations

Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Instituto de Pesquisa e Capacitação Física do Exército, Rio de Janeiro, Brazil.Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: Flaviafb@uerj.br.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27908545

Citation

Chain, Amina, et al. "Association Between Fat Mass and Bone Mineral Density Among Brazilian Women Differs By Menopausal Status: the Pró-Saúde Study." Nutrition (Burbank, Los Angeles County, Calif.), vol. 33, 2017, pp. 14-19.
Chain A, Crivelli M, Faerstein E, et al. Association between fat mass and bone mineral density among Brazilian women differs by menopausal status: The Pró-Saúde Study. Nutrition. 2017;33:14-19.
Chain, A., Crivelli, M., Faerstein, E., & Bezerra, F. F. (2017). Association between fat mass and bone mineral density among Brazilian women differs by menopausal status: The Pró-Saúde Study. Nutrition (Burbank, Los Angeles County, Calif.), 33, pp. 14-19. doi:10.1016/j.nut.2016.08.001.
Chain A, et al. Association Between Fat Mass and Bone Mineral Density Among Brazilian Women Differs By Menopausal Status: the Pró-Saúde Study. Nutrition. 2017;33:14-19. PubMed PMID: 27908545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between fat mass and bone mineral density among Brazilian women differs by menopausal status: The Pró-Saúde Study. AU - Chain,Amina, AU - Crivelli,Marise, AU - Faerstein,Eduardo, AU - Bezerra,Flávia F, Y1 - 2016/08/24/ PY - 2016/04/27/received PY - 2016/08/08/revised PY - 2016/08/11/accepted PY - 2016/12/3/entrez PY - 2016/12/3/pubmed PY - 2017/6/27/medline KW - Bone mineral density KW - DXA KW - Fat mass KW - Lean mass KW - Regression models SP - 14 EP - 19 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 33 N2 - OBJECTIVE: The aim of this study was to investigate the association between bone mineral density (BMD) and fat mass (FM) in a multiethnic population of Brazilian women and to evaluate the influence of total body mass and lean mass on this association. METHODS: This was a cross-sectional study nested within the Pro-Saúde Study, a prospective cohort of university civil servants in Rio de Janeiro. Participants were pre- (n = 100) and postmenopausal (n = 166) women. Total fat, lean mass, and BMD of total body, lumbar spine, and femoral neck were measured using dual energy x-ray absorptiometry. The association of BMD with FM was investigated after adjustment for total body mass (model 1) and lean mass (model 2) and potential confounding variables using multivariate linear regression models. RESULTS: In model 1, FM was inversely associated with BMD for total body (B = -0.010; P < 0.01) and for femoral neck (B = -0.009 P < 0.05) in premenopausal women. No association between FM and BMD was observed in postmenopausal women. Model 2 yielded direct associations between FM and BMD (total and specific sites; B = 0.003-0.008; P < 0.01) in postmenopausal women only. CONCLUSIONS: Independently of the adjustment used, the results of the present study suggest the absence of an inverse association between FM and BMD in postmenopausal women. Additionally, when adjusted for lean mass, a direct association between FM and bone mass can be observed, suggesting that for postmenopausal women being slightly obese does not confer excessive risk for bone loss and may even result in a bone density advantage. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/27908545/Association_between_fat_mass_and_bone_mineral_density_among_Brazilian_women_differs_by_menopausal_status:_The_Pró_Saúde_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(16)30165-4 DB - PRIME DP - Unbound Medicine ER -