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Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive Substances via Preclinical Models of Drug Self-administration.
Curr Top Behav Neurosci. 2017; 32:145-164.CT

Abstract

Animal models of drug self-administration are currently the gold standard for making predictions regarding the relative likelihood that a recreational drug substance will lead to continued use and addiction. Such models have been found to have high predictive accuracy and discriminative validity for a number of drug classes including ethanol, nicotine, opioids, and psychostimulants such as cocaine and methamphetamine. Members of the entactogen class of psychostimulants (drugs that produce an "open mind state" including feelings of interpersonal closeness, intimacy and empathy) have been less frequently studied in self-administration models. The prototypical entactogen 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") supports self-administration but not with the same consistency nor with the same efficacy as structurally related drugs amphetamine or methamphetamine. Consistent with these observations, MDMA use is more episodic in the majority of those who use it frequently. Nevertheless, substantial numbers of MDMA users will meet the criteria for substance dependence at some point in their use history. This review examines the currently available evidence from rodent self-administration studies of MDMA and two of the new and emerging psychoactive substances (NPS) that produce entactogen type neuropharmacological responses - mephedrone (4-methylmethcathinone; 4MMC; "meow meow") and methylone (3,4-methylenedioxymethcathinone). Overall, the current evidence predicts that these NPS entactogens have enhanced abuse liability compared with MDMA.

Authors+Show Affiliations

Committee on the Neurobiology of Addictive Disorders Mailcode SP30-2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.Committee on the Neurobiology of Addictive Disorders Mailcode SP30-2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. mtaffe@scripps.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

27909988

Citation

Aarde, Shawn M., and Michael A. Taffe. "Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive Substances Via Preclinical Models of Drug Self-administration." Current Topics in Behavioral Neurosciences, vol. 32, 2017, pp. 145-164.
Aarde SM, Taffe MA. Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive Substances via Preclinical Models of Drug Self-administration. Curr Top Behav Neurosci. 2017;32:145-164.
Aarde, S. M., & Taffe, M. A. (2017). Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive Substances via Preclinical Models of Drug Self-administration. Current Topics in Behavioral Neurosciences, 32, 145-164. https://doi.org/10.1007/7854_2016_54
Aarde SM, Taffe MA. Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive Substances Via Preclinical Models of Drug Self-administration. Curr Top Behav Neurosci. 2017;32:145-164. PubMed PMID: 27909988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive Substances via Preclinical Models of Drug Self-administration. AU - Aarde,Shawn M, AU - Taffe,Michael A, PY - 2016/12/3/pubmed PY - 2017/7/14/medline PY - 2016/12/3/entrez KW - Addiction KW - Drug abuse KW - Empathogen KW - Entactogen KW - MDMA KW - Mephedrone KW - Methylone KW - Self-administration SP - 145 EP - 164 JF - Current topics in behavioral neurosciences JO - Curr Top Behav Neurosci VL - 32 N2 - Animal models of drug self-administration are currently the gold standard for making predictions regarding the relative likelihood that a recreational drug substance will lead to continued use and addiction. Such models have been found to have high predictive accuracy and discriminative validity for a number of drug classes including ethanol, nicotine, opioids, and psychostimulants such as cocaine and methamphetamine. Members of the entactogen class of psychostimulants (drugs that produce an "open mind state" including feelings of interpersonal closeness, intimacy and empathy) have been less frequently studied in self-administration models. The prototypical entactogen 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy") supports self-administration but not with the same consistency nor with the same efficacy as structurally related drugs amphetamine or methamphetamine. Consistent with these observations, MDMA use is more episodic in the majority of those who use it frequently. Nevertheless, substantial numbers of MDMA users will meet the criteria for substance dependence at some point in their use history. This review examines the currently available evidence from rodent self-administration studies of MDMA and two of the new and emerging psychoactive substances (NPS) that produce entactogen type neuropharmacological responses - mephedrone (4-methylmethcathinone; 4MMC; "meow meow") and methylone (3,4-methylenedioxymethcathinone). Overall, the current evidence predicts that these NPS entactogens have enhanced abuse liability compared with MDMA. SN - 1866-3370 UR - https://www.unboundmedicine.com/medline/citation/27909988/Predicting_the_Abuse_Liability_of_Entactogen_Class_New_and_Emerging_Psychoactive_Substances_via_Preclinical_Models_of_Drug_Self_administration_ L2 - https://dx.doi.org/10.1007/7854_2016_54 DB - PRIME DP - Unbound Medicine ER -