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Effects of annual influenza vaccination on morbidity and mortality in patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study.

Abstract

Studies on the clinical efficacy of influenza vaccination on patients with systemic lupus erythematosus (SLE) are scant. The present study compared the incidence of hospitalization, morbidity, and mortality in patients with SLE between cohorts with and without influenza vaccination. We used the Taiwan's insurance claims data between 2001 and 2012 for identifying annual adult patients with SLE with (N = 1765) and without (N = 8360) influenza vaccination. The incidence rate ratio and hazard ratio (HR) for morbidities and mortality were measured for the vaccine and nonvaccine cohorts. The vaccine cohort had a lower hospitalization rate than did the nonvaccine cohort, with an adjusted HR of 0.82 (95% CI 0.73-0.92). Furthermore, the vaccine cohort was less likely to be admitted to the intensive care unit [adjusted HR 0.55 (95% CI 0.39-0.79)], to be hospitalized for septicemia, bacteremia, or viremia [adjusted HR 0.48 (95% CI 0.32-0.73)], to undergo in-hospital dialysis [adjusted HR 0.40 (95% CI 0.20-0.81)], and were less predisposed to death [adjusted HR 0.41 (95% CI 0.27-0.61)]. In conclusion, influenza vaccination in patients with SLE is associated with a reduced risk of morbidity and mortality.

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  • Authors+Show Affiliations

    ,

    Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan. Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

    ,

    Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

    ,

    Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taipei Veterans General Hospital, and National Yang-Ming University, Taipei, Taiwan.

    ,

    Biostatistics Center, College of Management, Taipei Medical University, Taipei, Taiwan.

    Biostatistics Center and School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan.

    Source

    Scientific reports 6: 2016 12 02 pg 37817

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Data Collection
    Dialysis
    Female
    Hospitalization
    Humans
    Incidence
    Influenza Vaccines
    Influenza, Human
    Intensive Care Units
    Lupus Erythematosus, Systemic
    Male
    Middle Aged
    Proportional Hazards Models
    Registries
    Retrospective Studies
    Risk
    Taiwan
    Vaccination
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27910867

    Citation

    Chang, Chi-Ching, et al. "Effects of Annual Influenza Vaccination On Morbidity and Mortality in Patients With Systemic Lupus Erythematosus: a Nationwide Cohort Study." Scientific Reports, vol. 6, 2016, p. 37817.
    Chang CC, Chang YS, Chen WS, et al. Effects of annual influenza vaccination on morbidity and mortality in patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study. Sci Rep. 2016;6:37817.
    Chang, C. C., Chang, Y. S., Chen, W. S., Chen, Y. H., & Chen, J. H. (2016). Effects of annual influenza vaccination on morbidity and mortality in patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study. Scientific Reports, 6, p. 37817. doi:10.1038/srep37817.
    Chang CC, et al. Effects of Annual Influenza Vaccination On Morbidity and Mortality in Patients With Systemic Lupus Erythematosus: a Nationwide Cohort Study. Sci Rep. 2016 12 2;6:37817. PubMed PMID: 27910867.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of annual influenza vaccination on morbidity and mortality in patients with Systemic Lupus Erythematosus: A Nationwide Cohort Study. AU - Chang,Chi-Ching, AU - Chang,Yu-Sheng, AU - Chen,Wei-Sheng, AU - Chen,Yi-Hsuan, AU - Chen,Jin-Hua, Y1 - 2016/12/02/ PY - 2016/03/01/received PY - 2016/10/31/accepted PY - 2016/12/3/entrez PY - 2016/12/3/pubmed PY - 2018/6/5/medline SP - 37817 EP - 37817 JF - Scientific reports JO - Sci Rep VL - 6 N2 - Studies on the clinical efficacy of influenza vaccination on patients with systemic lupus erythematosus (SLE) are scant. The present study compared the incidence of hospitalization, morbidity, and mortality in patients with SLE between cohorts with and without influenza vaccination. We used the Taiwan's insurance claims data between 2001 and 2012 for identifying annual adult patients with SLE with (N = 1765) and without (N = 8360) influenza vaccination. The incidence rate ratio and hazard ratio (HR) for morbidities and mortality were measured for the vaccine and nonvaccine cohorts. The vaccine cohort had a lower hospitalization rate than did the nonvaccine cohort, with an adjusted HR of 0.82 (95% CI 0.73-0.92). Furthermore, the vaccine cohort was less likely to be admitted to the intensive care unit [adjusted HR 0.55 (95% CI 0.39-0.79)], to be hospitalized for septicemia, bacteremia, or viremia [adjusted HR 0.48 (95% CI 0.32-0.73)], to undergo in-hospital dialysis [adjusted HR 0.40 (95% CI 0.20-0.81)], and were less predisposed to death [adjusted HR 0.41 (95% CI 0.27-0.61)]. In conclusion, influenza vaccination in patients with SLE is associated with a reduced risk of morbidity and mortality. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/27910867/Effects_of_annual_influenza_vaccination_on_morbidity_and_mortality_in_patients_with_Systemic_Lupus_Erythematosus:_A_Nationwide_Cohort_Study_ L2 - http://dx.doi.org/10.1038/srep37817 DB - PRIME DP - Unbound Medicine ER -