Tags

Type your tag names separated by a space and hit enter

Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation.
Mov Disord. 2017 02; 32(2):274-277.MD

Abstract

BACKGROUND

The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions.

METHODS

PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score.

RESULTS

DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found.

CONCLUSIONS

STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons. © 2016 International Parkinson and Movement Disorder Society.

Authors+Show Affiliations

Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.Banner Sun Health Research Institute, Sun City, Arizona, USA.Banner Sun Health Research Institute, Sun City, Arizona, USA.Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.Department of Neurological Sciences, Rush University, Chicago, Illinois, USA.Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.Banner Sun Health Research Institute, Sun City, Arizona, USA.Banner Sun Health Research Institute, Sun City, Arizona, USA. Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.Banner Sun Health Research Institute, Sun City, Arizona, USA. Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27911008

Citation

Pal, Gian D., et al. "Comparison of Neuropathology in Parkinson's Disease Subjects With and Without Deep Brain Stimulation." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 32, no. 2, 2017, pp. 274-277.
Pal GD, Ouyang B, Serrano G, et al. Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation. Mov Disord. 2017;32(2):274-277.
Pal, G. D., Ouyang, B., Serrano, G., Shill, H. A., Goetz, C., Stebbins, G., Metman, L. V., Driver-Dunckley, E., Mehta, S. H., Caviness, J. N., Sabbagh, M. N., Adler, C. H., & Beach, T. G. (2017). Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation. Movement Disorders : Official Journal of the Movement Disorder Society, 32(2), 274-277. https://doi.org/10.1002/mds.26882
Pal GD, et al. Comparison of Neuropathology in Parkinson's Disease Subjects With and Without Deep Brain Stimulation. Mov Disord. 2017;32(2):274-277. PubMed PMID: 27911008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation. AU - Pal,Gian D, AU - Ouyang,Bichun, AU - Serrano,Geidy, AU - Shill,Holly A, AU - Goetz,Christopher, AU - Stebbins,Glenn, AU - Metman,Leo Verhagen, AU - Driver-Dunckley,Erika, AU - Mehta,Shyamal H, AU - Caviness,John N, AU - Sabbagh,Marwan N, AU - Adler,Charles H, AU - Beach,Thomas G, AU - ,, Y1 - 2016/12/02/ PY - 2016/08/01/received PY - 2016/09/30/revised PY - 2016/10/02/accepted PY - 2016/12/3/pubmed PY - 2017/12/30/medline PY - 2016/12/3/entrez KW - Lewy body KW - Parkinson's disease KW - alpha-synuclein KW - deep brain stimulation KW - subthalamic nucleus SP - 274 EP - 277 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 32 IS - 2 N2 - BACKGROUND: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. METHODS: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. RESULTS: DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. CONCLUSIONS: STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons. © 2016 International Parkinson and Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/27911008/Comparison_of_neuropathology_in_Parkinson's_disease_subjects_with_and_without_deep_brain_stimulation_ L2 - https://doi.org/10.1002/mds.26882 DB - PRIME DP - Unbound Medicine ER -