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Association between Parkinson's disease and risk of colorectal cancer.
Parkinsonism Relat Disord. 2017 02; 35:42-47.PR

Abstract

BACKGROUND

Growing evidence has reported that gut microbiota is involved in pathogenesis of Parkinson's disease (PD) and colorectal cancer (CRC), and the association between PD and CRC does not reach a consensus. In order to explore their correlation, herein we summarize the epidemiological evidence and included relevant studies to perform a meta-analysis.

METHODS

A comprehensive literature search for relevant articles published was performed in Medline, Web of Science and Embase up to June 30, 2016. The pooled risk ratio (RR) with 95% confidence intervals (CI) was used to estimate the effects and calculated using the method of generic inverse variance with the Random-effects model.

RESULTS

Thirteen studies were included and analyzed in this meta-analysis. The pooled result of 11 cohort studies and 2 case-control studies comprising 343,226 PD patients showed that patients with PD had a decreased risk of CRC (RR: 0.79, 95% CI: 0.66-0.93, P = 0.006). Further subgroup analyses performed in Western population revealed that the significant inverse association between PD and risk of CRC was not undermined by many factors, including study design, tumor location, gender and quality of the study.

CONCLUSION

Patients with PD was significantly associated with a decreased risk of CRC in Western population. Future studies are warranted to further clarify this association in Asian population.

Authors+Show Affiliations

Department of Neurology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City 110001, PR China.Department of Neurology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang City 110001, PR China. Electronic address: grace_shenyang@163.com.Clinics of the People's Armed Police Command College, Tianjin City, 300000, PR China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27913126

Citation

Xie, Xin, et al. "Association Between Parkinson's Disease and Risk of Colorectal Cancer." Parkinsonism & Related Disorders, vol. 35, 2017, pp. 42-47.
Xie X, Luo X, Xie M. Association between Parkinson's disease and risk of colorectal cancer. Parkinsonism Relat Disord. 2017;35:42-47.
Xie, X., Luo, X., & Xie, M. (2017). Association between Parkinson's disease and risk of colorectal cancer. Parkinsonism & Related Disorders, 35, 42-47. https://doi.org/10.1016/j.parkreldis.2016.11.011
Xie X, Luo X, Xie M. Association Between Parkinson's Disease and Risk of Colorectal Cancer. Parkinsonism Relat Disord. 2017;35:42-47. PubMed PMID: 27913126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Parkinson's disease and risk of colorectal cancer. AU - Xie,Xin, AU - Luo,Xiaoguang, AU - Xie,Mingliang, Y1 - 2016/11/22/ PY - 2016/08/08/received PY - 2016/10/03/revised PY - 2016/11/20/accepted PY - 2016/12/4/pubmed PY - 2018/2/16/medline PY - 2016/12/4/entrez KW - Colorectal neoplasms KW - Meta-analysis KW - Parkinson's disease KW - Risk SP - 42 EP - 47 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 35 N2 - BACKGROUND: Growing evidence has reported that gut microbiota is involved in pathogenesis of Parkinson's disease (PD) and colorectal cancer (CRC), and the association between PD and CRC does not reach a consensus. In order to explore their correlation, herein we summarize the epidemiological evidence and included relevant studies to perform a meta-analysis. METHODS: A comprehensive literature search for relevant articles published was performed in Medline, Web of Science and Embase up to June 30, 2016. The pooled risk ratio (RR) with 95% confidence intervals (CI) was used to estimate the effects and calculated using the method of generic inverse variance with the Random-effects model. RESULTS: Thirteen studies were included and analyzed in this meta-analysis. The pooled result of 11 cohort studies and 2 case-control studies comprising 343,226 PD patients showed that patients with PD had a decreased risk of CRC (RR: 0.79, 95% CI: 0.66-0.93, P = 0.006). Further subgroup analyses performed in Western population revealed that the significant inverse association between PD and risk of CRC was not undermined by many factors, including study design, tumor location, gender and quality of the study. CONCLUSION: Patients with PD was significantly associated with a decreased risk of CRC in Western population. Future studies are warranted to further clarify this association in Asian population. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/27913126/Association_between_Parkinson's_disease_and_risk_of_colorectal_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(16)30456-4 DB - PRIME DP - Unbound Medicine ER -