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Comparison of OCT angiography and indocyanine green angiographic findings with subtypes of polypoidal choroidal vasculopathy.
Br J Ophthalmol. 2017 Jan; 101(1):51-55.BJ

Abstract

PURPOSE

To compare the findings of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV) that was divided into two types: polypoidal choroidal neovascularisation (CNV) and typical PCV (type 2 PCV).

METHODS

We studied a retrospective case series of 32 patients with treatment-naïve PCV (24 men, eight women; mean age 65.4 years). PCV was categorised into polypoidal CNV (type 1 PCV) and type 2 PCV based on ICGA findings. OCTA was performed using the RTVue XR Avanti. Macular cubes (3×3 or 6×6 mm) were acquired. To evaluate the locations of polyps and branched vessel networks (BVNs), we used B-mode scan.

RESULTS

OCTA clearly depicted only 17% of the type 1 PCV polyps and 46% of the type 2 PCV polyps which were detectable by ICGA. All type 1 PCV polyps detectable by OCTA were located just beneath the retinal pigment epithelium (RPE). On the other hand, type 2 PCV polyps were detected in various locations. All BVNs of type 1 PCV were located between the RPE and Bruch's membrane on OCTA images. However, the BVNs in type 2 PCV were located mainly under the RPE, though some were located in the choroid.

CONCLUSIONS

Polyps of type 1 PCV were more difficult to detect with OCTA than those of type 2 PCV. Polyps of type 1 PCV were located just beneath the RPE. The BVNs of type 1 PCV were located between the RPE and Bruch's membrane.

Authors+Show Affiliations

Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27913447

Citation

Tanaka, Koji, et al. "Comparison of OCT Angiography and Indocyanine Green Angiographic Findings With Subtypes of Polypoidal Choroidal Vasculopathy." The British Journal of Ophthalmology, vol. 101, no. 1, 2017, pp. 51-55.
Tanaka K, Mori R, Kawamura A, et al. Comparison of OCT angiography and indocyanine green angiographic findings with subtypes of polypoidal choroidal vasculopathy. Br J Ophthalmol. 2017;101(1):51-55.
Tanaka, K., Mori, R., Kawamura, A., Nakashizuka, H., Wakatsuki, Y., & Yuzawa, M. (2017). Comparison of OCT angiography and indocyanine green angiographic findings with subtypes of polypoidal choroidal vasculopathy. The British Journal of Ophthalmology, 101(1), 51-55. https://doi.org/10.1136/bjophthalmol-2016-309264
Tanaka K, et al. Comparison of OCT Angiography and Indocyanine Green Angiographic Findings With Subtypes of Polypoidal Choroidal Vasculopathy. Br J Ophthalmol. 2017;101(1):51-55. PubMed PMID: 27913447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of OCT angiography and indocyanine green angiographic findings with subtypes of polypoidal choroidal vasculopathy. AU - Tanaka,Koji, AU - Mori,Ryusaburo, AU - Kawamura,Akiyuki, AU - Nakashizuka,Hiroyuki, AU - Wakatsuki,Yu, AU - Yuzawa,Mitsuko, Y1 - 2016/12/02/ PY - 2016/06/28/received PY - 2016/11/09/revised PY - 2016/11/15/accepted PY - 2016/12/4/pubmed PY - 2017/5/26/medline PY - 2016/12/4/entrez KW - Imaging KW - Neovascularisation KW - Retina SP - 51 EP - 55 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 101 IS - 1 N2 - PURPOSE: To compare the findings of optical coherence tomography angiography (OCTA) with indocyanine green angiography (ICGA) in polypoidal choroidal vasculopathy (PCV) that was divided into two types: polypoidal choroidal neovascularisation (CNV) and typical PCV (type 2 PCV). METHODS: We studied a retrospective case series of 32 patients with treatment-naïve PCV (24 men, eight women; mean age 65.4 years). PCV was categorised into polypoidal CNV (type 1 PCV) and type 2 PCV based on ICGA findings. OCTA was performed using the RTVue XR Avanti. Macular cubes (3×3 or 6×6 mm) were acquired. To evaluate the locations of polyps and branched vessel networks (BVNs), we used B-mode scan. RESULTS: OCTA clearly depicted only 17% of the type 1 PCV polyps and 46% of the type 2 PCV polyps which were detectable by ICGA. All type 1 PCV polyps detectable by OCTA were located just beneath the retinal pigment epithelium (RPE). On the other hand, type 2 PCV polyps were detected in various locations. All BVNs of type 1 PCV were located between the RPE and Bruch's membrane on OCTA images. However, the BVNs in type 2 PCV were located mainly under the RPE, though some were located in the choroid. CONCLUSIONS: Polyps of type 1 PCV were more difficult to detect with OCTA than those of type 2 PCV. Polyps of type 1 PCV were located just beneath the RPE. The BVNs of type 1 PCV were located between the RPE and Bruch's membrane. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/27913447/Comparison_of_OCT_angiography_and_indocyanine_green_angiographic_findings_with_subtypes_of_polypoidal_choroidal_vasculopathy_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&pmid=27913447 DB - PRIME DP - Unbound Medicine ER -