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Association between Dietary Isoflavones in Soy and Legumes and Endometrial Cancer: A Systematic Review and Meta-Analysis.
J Acad Nutr Diet 2018; 118(4):637-651JA

Abstract

BACKGROUND

Epidemiologic studies have reported conflicting findings between soy- and legume-derived dietary isoflavones and risk of endometrial cancer.

OBJECTIVE

The aim of the present meta-analysis was to quantitatively investigate the association between daily intake of soy- and legume-derived isoflavones and risk of endometrial cancer.

DESIGN

A broad search was conducted in the following electronic databases: PubMed, EMBASE, Google Scholar, the Cochrane Library, the China Knowledge Resource Integrated Database, and the Chinese Biomedical Database based on combinations of the key words endometrial cancer, isoflavone, soy, and legume for epidemiologic studies that focused on relationships between dietary isoflavones and endometrial cancer risk. A fixed-effect or random-effect model was used to pool study-specific risk estimates.

RESULTS

A total of 13 epidemiologic studies were included in the present meta-analysis, consisting of three prospective cohort studies and 10 population-based case-control studies. The final results indicated that higher dietary isoflavone levels from soy products and legumes were associated with a reduced risk of endometrial cancer (odds ratio [OR] 0.81, 95% CI 0.74 to 0.89). Low heterogeneous bias was observed (I2=11.7%; P=0.327). Subgroup analyses were conducted based on study design, source of dietary isoflavones, and study region. When restricted to study design, dietary isoflavones from soy and legumes played a role in prevention of endometrial cancer in case-control studies (OR 0.81, 95% CI 0.73 to 0.90). However, there did not appear to be an association between dietary isoflavones and endometrial cancer in cohort studies (OR 0.81, 95% CI 0.66 to 1.00). Significant associations were found between dietary isoflavones from soy products (OR 0.82, 95% CI 0.72 to 0.92) and legumes (OR 0.84, 95% CI 0.74 to 0.96) and endometrial cancer. Dietary isoflavones were associated with reduced incidence of endometrial cancer, both in Asian countries (OR 0.78, 95% CI 0.66 to 0.93) and non-Asian countries (OR 0.82, 95% CI 0.73 to 0.92).

CONCLUSIONS

The findings suggest a weak inverse association between higher consumption of dietary isoflavones from soy products and legumes and endometrial cancer risk. However, there is still a need for large, prospective epidemiologic studies that provide a higher level of evidence to verify these findings.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

27914914

Citation

Zhong, Xue-Shan, et al. "Association Between Dietary Isoflavones in Soy and Legumes and Endometrial Cancer: a Systematic Review and Meta-Analysis." Journal of the Academy of Nutrition and Dietetics, vol. 118, no. 4, 2018, pp. 637-651.
Zhong XS, Ge J, Chen SW, et al. Association between Dietary Isoflavones in Soy and Legumes and Endometrial Cancer: A Systematic Review and Meta-Analysis. J Acad Nutr Diet. 2018;118(4):637-651.
Zhong, X. S., Ge, J., Chen, S. W., Xiong, Y. Q., Ma, S. J., & Chen, Q. (2018). Association between Dietary Isoflavones in Soy and Legumes and Endometrial Cancer: A Systematic Review and Meta-Analysis. Journal of the Academy of Nutrition and Dietetics, 118(4), pp. 637-651. doi:10.1016/j.jand.2016.09.036.
Zhong XS, et al. Association Between Dietary Isoflavones in Soy and Legumes and Endometrial Cancer: a Systematic Review and Meta-Analysis. J Acad Nutr Diet. 2018;118(4):637-651. PubMed PMID: 27914914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Dietary Isoflavones in Soy and Legumes and Endometrial Cancer: A Systematic Review and Meta-Analysis. AU - Zhong,Xue-Shan, AU - Ge,Jing, AU - Chen,Shao-Wei, AU - Xiong,Yi-Quan, AU - Ma,Shu-Juan, AU - Chen,Qing, Y1 - 2016/12/01/ PY - 2016/01/28/received PY - 2016/09/28/accepted PY - 2016/12/5/pubmed PY - 2019/9/26/medline PY - 2016/12/5/entrez KW - Endometrial cancer KW - Isoflavones KW - Legume KW - Meta-analysis KW - Soy SP - 637 EP - 651 JF - Journal of the Academy of Nutrition and Dietetics JO - J Acad Nutr Diet VL - 118 IS - 4 N2 - BACKGROUND: Epidemiologic studies have reported conflicting findings between soy- and legume-derived dietary isoflavones and risk of endometrial cancer. OBJECTIVE: The aim of the present meta-analysis was to quantitatively investigate the association between daily intake of soy- and legume-derived isoflavones and risk of endometrial cancer. DESIGN: A broad search was conducted in the following electronic databases: PubMed, EMBASE, Google Scholar, the Cochrane Library, the China Knowledge Resource Integrated Database, and the Chinese Biomedical Database based on combinations of the key words endometrial cancer, isoflavone, soy, and legume for epidemiologic studies that focused on relationships between dietary isoflavones and endometrial cancer risk. A fixed-effect or random-effect model was used to pool study-specific risk estimates. RESULTS: A total of 13 epidemiologic studies were included in the present meta-analysis, consisting of three prospective cohort studies and 10 population-based case-control studies. The final results indicated that higher dietary isoflavone levels from soy products and legumes were associated with a reduced risk of endometrial cancer (odds ratio [OR] 0.81, 95% CI 0.74 to 0.89). Low heterogeneous bias was observed (I2=11.7%; P=0.327). Subgroup analyses were conducted based on study design, source of dietary isoflavones, and study region. When restricted to study design, dietary isoflavones from soy and legumes played a role in prevention of endometrial cancer in case-control studies (OR 0.81, 95% CI 0.73 to 0.90). However, there did not appear to be an association between dietary isoflavones and endometrial cancer in cohort studies (OR 0.81, 95% CI 0.66 to 1.00). Significant associations were found between dietary isoflavones from soy products (OR 0.82, 95% CI 0.72 to 0.92) and legumes (OR 0.84, 95% CI 0.74 to 0.96) and endometrial cancer. Dietary isoflavones were associated with reduced incidence of endometrial cancer, both in Asian countries (OR 0.78, 95% CI 0.66 to 0.93) and non-Asian countries (OR 0.82, 95% CI 0.73 to 0.92). CONCLUSIONS: The findings suggest a weak inverse association between higher consumption of dietary isoflavones from soy products and legumes and endometrial cancer risk. However, there is still a need for large, prospective epidemiologic studies that provide a higher level of evidence to verify these findings. SN - 2212-2672 UR - https://www.unboundmedicine.com/medline/citation/27914914/Association_between_Dietary_Isoflavones_in_Soy_and_Legumes_and_Endometrial_Cancer:_A_Systematic_Review_and_Meta_Analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-2672(16)31203-5 DB - PRIME DP - Unbound Medicine ER -