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Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds.
Int J Biol Macromol. 2017 Feb; 95:625-634.IJ

Abstract

The aim of this work was to evaluate the antioxidant and hemolytic activities as well as the in vivo wound healing performance of a novel polysaccharide (FWEP) extracted from fenugreek (Trigonella foenum-graecum) seeds. The antioxidant activity was evaluated in vivo and in vitro using various assays. Results showed that FWEP exhibited strong antioxidant activities but no hemolytic activity was observed towards bovine erythrocytes. The application of FWEP hydrogel on the wound site in a rat model enhanced significantly wound healing activity and accelerated the wound closure after 14days of wound induction. Histological examination also demonstrated fully re-epithelialized wound with a complete epidermal regeneration. Altogether, these evidences demonstrated that FWEP had strong wound healing potential presumably achieved through its antioxidant activities.

Authors+Show Affiliations

Laboratory of Enzyme Engineering and Microbiology, National School of Engineering of Sfax, University of Sfax, P.O. 1173-3038, Sfax, Tunisia.Laboratory of Microorganisms and Biomolecules (LMB), Centre of Biotechnology of Sfax, Road of Sidi Mansour Km 6, P.O. Box 1177, Sfax 3018, Tunisia.Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Avenue Majida Boulila, Sfax 3029, Tunisia.Laboratory of Microorganisms and Biomolecules (LMB), Centre of Biotechnology of Sfax, Road of Sidi Mansour Km 6, P.O. Box 1177, Sfax 3018, Tunisia.Laboratory of Enzyme Engineering and Microbiology, National School of Engineering of Sfax, University of Sfax, P.O. 1173-3038, Sfax, Tunisia.Laboratory of Enzyme Engineering and Microbiology, National School of Engineering of Sfax, University of Sfax, P.O. 1173-3038, Sfax, Tunisia.Laboratory of Enzyme Engineering and Microbiology, National School of Engineering of Sfax, University of Sfax, P.O. 1173-3038, Sfax, Tunisia.Laboratory of Microorganisms and Biomolecules (LMB), Centre of Biotechnology of Sfax, Road of Sidi Mansour Km 6, P.O. Box 1177, Sfax 3018, Tunisia. Electronic address: riadh_fss@yahoo.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27914964

Citation

Ktari, Naourez, et al. "Antioxidant and Hemolytic Activities, and Effects in Rat Cutaneous Wound Healing of a Novel Polysaccharide From Fenugreek (Trigonella Foenum-graecum) Seeds." International Journal of Biological Macromolecules, vol. 95, 2017, pp. 625-634.
Ktari N, Trabelsi I, Bardaa S, et al. Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds. Int J Biol Macromol. 2017;95:625-634.
Ktari, N., Trabelsi, I., Bardaa, S., Triki, M., Bkhairia, I., Ben Slama-Ben Salem, R., Nasri, M., & Ben Salah, R. (2017). Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds. International Journal of Biological Macromolecules, 95, 625-634. https://doi.org/10.1016/j.ijbiomac.2016.11.091
Ktari N, et al. Antioxidant and Hemolytic Activities, and Effects in Rat Cutaneous Wound Healing of a Novel Polysaccharide From Fenugreek (Trigonella Foenum-graecum) Seeds. Int J Biol Macromol. 2017;95:625-634. PubMed PMID: 27914964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds. AU - Ktari,Naourez, AU - Trabelsi,Imen, AU - Bardaa,Sana, AU - Triki,Mehdi, AU - Bkhairia,Intidhar, AU - Ben Slama-Ben Salem,Rabab, AU - Nasri,Moncef, AU - Ben Salah,Riadh, Y1 - 2016/11/30/ PY - 2016/09/28/received PY - 2016/10/25/revised PY - 2016/11/23/accepted PY - 2016/12/5/pubmed PY - 2017/4/12/medline PY - 2016/12/5/entrez KW - Antioxidant activities KW - Fenugreek seeds KW - Hemolytic activity KW - Polysaccharide KW - Wound healing SP - 625 EP - 634 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 95 N2 - The aim of this work was to evaluate the antioxidant and hemolytic activities as well as the in vivo wound healing performance of a novel polysaccharide (FWEP) extracted from fenugreek (Trigonella foenum-graecum) seeds. The antioxidant activity was evaluated in vivo and in vitro using various assays. Results showed that FWEP exhibited strong antioxidant activities but no hemolytic activity was observed towards bovine erythrocytes. The application of FWEP hydrogel on the wound site in a rat model enhanced significantly wound healing activity and accelerated the wound closure after 14days of wound induction. Histological examination also demonstrated fully re-epithelialized wound with a complete epidermal regeneration. Altogether, these evidences demonstrated that FWEP had strong wound healing potential presumably achieved through its antioxidant activities. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/27914964/Antioxidant_and_hemolytic_activities_and_effects_in_rat_cutaneous_wound_healing_of_a_novel_polysaccharide_from_fenugreek__Trigonella_foenum_graecum__seeds_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(16)31809-8 DB - PRIME DP - Unbound Medicine ER -