Tags

Type your tag names separated by a space and hit enter

The Association of Family History of Premature Cardiovascular Disease or Diabetes Mellitus on the Occurrence of Gestational Hypertensive Disease and Diabetes.
PLoS One. 2016; 11(12):e0167528.Plos

Abstract

BACKGROUND

Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) increase the risk of cardiovascular disease (CVD) later in life. However, the association between gestational medical diseases and familial history of CVD has not been investigated to date. In the present study, we examined the association between familial history of CVD and GHD or GDM via reliable questionnaires in a large cohort of registered nurses.

METHODS

The Korean Nurses' Survey was conducted through a web-based computer-assisted self-interview, which was developed through consultation with cardiologists, gynecologists, and statisticians. We enrolled a total of 9,989 female registered nurses who reliably answered the questionnaires including family history of premature CVD (FHpCVD), hypertension (FHH), and diabetes mellitus (FHDM) based on their medical knowledge. Either multivariable logistic regression analysis or generalized estimation equation was used to clarify the effect of positive family histories on GHD and GDM in subjects or at each repeated pregnancy in an individual.

RESULTS

In this survey, 3,695 subjects had at least 1 pregnancy and 8,783 cumulative pregnancies. Among them, 247 interviewees (6.3%) experienced GHD and 120 (3.1%) experienced GDM. In a multivariable analysis adjusted for age, obstetric, and gynecologic variables, age at the first pregnancy over 35 years (adjusted OR 1.61, 95% CI 1.02-2.43) and FHpCVD (adjusted OR 1.60, 95% CI 1.16-2.22) were risk factors for GHD in individuals, whereas FHH was not. FHDM and history of infertility therapy were risk factors for GDM in individuals (adjusted OR 2.68, 95% CI 1.86-3.86; 1.84, 95% CI 1.05-3.23, respectively). In any repeated pregnancies in an individual, age at the current pregnancy and at the first pregnancy, and FHpCVD were risk factors for GHD, while age at the current pregnancy, history of infertility therapy, and FHDM were risk factors for GDM.

CONCLUSIONS

The FHpCVD and FHDM are significantly associated with GHD and GDM, respectively. Meticulous family histories should be obtained, and women with family histories of these conditions should be carefully monitored during pregnancy.

Authors+Show Affiliations

Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea.Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea.Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea.MRCC, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Obstetrics & Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.Division of Cardiovascular and Rare Diseases, Center for Biomedical Science, National Institute of Health, Chungbuk, Korea.Korean Nurses Association, Seoul, Korea.Department of Internal Medicine, Chungbuk National University, Chungbuk, Korea.Cardiology Division, School of Medicine, Ewha Womans University, Seoul, Korea.Division of Cardiology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.Division of Cardiology, Cardiovascular Imaging Center, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Cardiology Division, Severance Cardiovascular Hospital, Yonsei University, Seoul, Korea.Department of Cardiovascular Medicine, Dongtan Sacred Heart Hospital, Hwaseong, Korea.Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27918585

Citation

Choi, Dong-Ju, et al. "The Association of Family History of Premature Cardiovascular Disease or Diabetes Mellitus On the Occurrence of Gestational Hypertensive Disease and Diabetes." PloS One, vol. 11, no. 12, 2016, pp. e0167528.
Choi DJ, Yoon CH, Lee H, et al. The Association of Family History of Premature Cardiovascular Disease or Diabetes Mellitus on the Occurrence of Gestational Hypertensive Disease and Diabetes. PLoS ONE. 2016;11(12):e0167528.
Choi, D. J., Yoon, C. H., Lee, H., Ahn, S. Y., Oh, K. J., Park, H. Y., Lee, H. Y., Cho, M. C., Chung, I. M., Shin, M. S., Park, S. J., Shim, C. Y., Han, S. W., & Chae, I. H. (2016). The Association of Family History of Premature Cardiovascular Disease or Diabetes Mellitus on the Occurrence of Gestational Hypertensive Disease and Diabetes. PloS One, 11(12), e0167528. https://doi.org/10.1371/journal.pone.0167528
Choi DJ, et al. The Association of Family History of Premature Cardiovascular Disease or Diabetes Mellitus On the Occurrence of Gestational Hypertensive Disease and Diabetes. PLoS ONE. 2016;11(12):e0167528. PubMed PMID: 27918585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association of Family History of Premature Cardiovascular Disease or Diabetes Mellitus on the Occurrence of Gestational Hypertensive Disease and Diabetes. AU - Choi,Dong-Ju, AU - Yoon,Chang-Hwan, AU - Lee,Heesun, AU - Ahn,So-Yeon, AU - Oh,Kyung Joon, AU - Park,Hyun-Young, AU - Lee,Hea Young, AU - Cho,Myeong Chan, AU - Chung,Ick-Mo, AU - Shin,Mi-Seung, AU - Park,Sung-Ji, AU - Shim,Chi Young, AU - Han,Seong Woo, AU - Chae,In-Ho, Y1 - 2016/12/05/ PY - 2016/07/29/received PY - 2016/11/15/accepted PY - 2016/12/6/entrez PY - 2016/12/6/pubmed PY - 2017/7/4/medline SP - e0167528 EP - e0167528 JF - PloS one JO - PLoS ONE VL - 11 IS - 12 N2 - BACKGROUND: Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) increase the risk of cardiovascular disease (CVD) later in life. However, the association between gestational medical diseases and familial history of CVD has not been investigated to date. In the present study, we examined the association between familial history of CVD and GHD or GDM via reliable questionnaires in a large cohort of registered nurses. METHODS: The Korean Nurses' Survey was conducted through a web-based computer-assisted self-interview, which was developed through consultation with cardiologists, gynecologists, and statisticians. We enrolled a total of 9,989 female registered nurses who reliably answered the questionnaires including family history of premature CVD (FHpCVD), hypertension (FHH), and diabetes mellitus (FHDM) based on their medical knowledge. Either multivariable logistic regression analysis or generalized estimation equation was used to clarify the effect of positive family histories on GHD and GDM in subjects or at each repeated pregnancy in an individual. RESULTS: In this survey, 3,695 subjects had at least 1 pregnancy and 8,783 cumulative pregnancies. Among them, 247 interviewees (6.3%) experienced GHD and 120 (3.1%) experienced GDM. In a multivariable analysis adjusted for age, obstetric, and gynecologic variables, age at the first pregnancy over 35 years (adjusted OR 1.61, 95% CI 1.02-2.43) and FHpCVD (adjusted OR 1.60, 95% CI 1.16-2.22) were risk factors for GHD in individuals, whereas FHH was not. FHDM and history of infertility therapy were risk factors for GDM in individuals (adjusted OR 2.68, 95% CI 1.86-3.86; 1.84, 95% CI 1.05-3.23, respectively). In any repeated pregnancies in an individual, age at the current pregnancy and at the first pregnancy, and FHpCVD were risk factors for GHD, while age at the current pregnancy, history of infertility therapy, and FHDM were risk factors for GDM. CONCLUSIONS: The FHpCVD and FHDM are significantly associated with GHD and GDM, respectively. Meticulous family histories should be obtained, and women with family histories of these conditions should be carefully monitored during pregnancy. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27918585/The_Association_of_Family_History_of_Premature_Cardiovascular_Disease_or_Diabetes_Mellitus_on_the_Occurrence_of_Gestational_Hypertensive_Disease_and_Diabetes_ L2 - http://dx.plos.org/10.1371/journal.pone.0167528 DB - PRIME DP - Unbound Medicine ER -