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Red ginseng powder fermented with probiotics exerts antidiabetic effects in the streptozotocin-induced mouse diabetes model.
Pharm Biol. 2017 Dec; 55(1):317-323.PB

Abstract

CONTEXT

Red ginseng (heat-processed Panax ginseng) is a well-known alternative medicine with pharmacological antidiabetic activity. It exerts pharmacological effects through the transformation of saponin into metabolites by the intestinal microbiota. Given that intestinal conditions and intestinal microflora vary among individuals, the pharmacological effects of orally administered red ginseng likely may vary among individuals.

OBJECTIVE

To overcome this variation and produce homogeneously effective red ginseng, we evaluated the antidiabetic effects of probiotic-fermented red ginseng in a mouse model.

MATERIALS AND METHODS

The antidiabetic efficacy of orally administered probiotic-fermented red ginseng was assessed in ICR mice after induction of diabetes using streptozotocin (170 mg/kg body weight). Samples were given orally for 8 weeks, and indicators involved in diabetic disorders such as body weight change, water intake, blood glucose, glucose tolerance and various biochemical parameters were determined.

RESULTS

Oral administration of probiotic-fermented red ginseng significantly decreased the level of blood glucose of about 62.5% in the fasting state and induced a significant increase in glucose tolerance of about 10.2% compared to the control diabetic mice. Additionally, various indicators of diabetes and biochemical data (e.g., blood glycosylated haemoglobin level, serum concentrations of insulin, and α-amylase activity) showed a significant improvement in the diabetic conditions of the mice treated with probiotic-fermented red ginseng in comparison with those of control diabetic mice.

DISCUSSION AND CONCLUSION

Our results demonstrate the antidiabetic effects of probiotic-fermented red ginseng in the streptozotocin-induced mouse diabetes model and suggest that probiotic-fermented red ginseng may be a uniformly effective red ginseng product.

Authors+Show Affiliations

a Department of Molecular Biology and the Institute for Molecular Biology and Genetics , Chonbuk National University , Jeonju , Korea.b Department of Bioactive Material Sciences and Research Center of Bioactive Materials , Chonbuk National University , Jeonju , Korea.a Department of Molecular Biology and the Institute for Molecular Biology and Genetics , Chonbuk National University , Jeonju , Korea. b Department of Bioactive Material Sciences and Research Center of Bioactive Materials , Chonbuk National University , Jeonju , Korea.c Department of Efficacy Research , Institute of Jinan Red Ginseng , Jinan , Korea.c Department of Efficacy Research , Institute of Jinan Red Ginseng , Jinan , Korea.c Department of Efficacy Research , Institute of Jinan Red Ginseng , Jinan , Korea.d Department of Mathematics , Sogang University , Seoul , Korea.e Department of Oral Maxillofacial Surgery , Korea University Ansan Hospital , Ansan , Korea.a Department of Molecular Biology and the Institute for Molecular Biology and Genetics , Chonbuk National University , Jeonju , Korea. c Department of Efficacy Research , Institute of Jinan Red Ginseng , Jinan , Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27927080

Citation

Jang, Sun-Hee, et al. "Red Ginseng Powder Fermented With Probiotics Exerts Antidiabetic Effects in the Streptozotocin-induced Mouse Diabetes Model." Pharmaceutical Biology, vol. 55, no. 1, 2017, pp. 317-323.
Jang SH, Park J, Kim SH, et al. Red ginseng powder fermented with probiotics exerts antidiabetic effects in the streptozotocin-induced mouse diabetes model. Pharm Biol. 2017;55(1):317-323.
Jang, S. H., Park, J., Kim, S. H., Choi, K. M., Ko, E. S., Cha, J. D., Lee, Y. R., Jang, H., & Jang, Y. S. (2017). Red ginseng powder fermented with probiotics exerts antidiabetic effects in the streptozotocin-induced mouse diabetes model. Pharmaceutical Biology, 55(1), 317-323.
Jang SH, et al. Red Ginseng Powder Fermented With Probiotics Exerts Antidiabetic Effects in the Streptozotocin-induced Mouse Diabetes Model. Pharm Biol. 2017;55(1):317-323. PubMed PMID: 27927080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red ginseng powder fermented with probiotics exerts antidiabetic effects in the streptozotocin-induced mouse diabetes model. AU - Jang,Sun-Hee, AU - Park,Jisang, AU - Kim,Sae-Hae, AU - Choi,Kyung-Min, AU - Ko,Eun-Sil, AU - Cha,Jeong-Dan, AU - Lee,Young-Ran, AU - Jang,Hyonseok, AU - Jang,Yong-Suk, PY - 2016/12/9/entrez PY - 2016/12/9/pubmed PY - 2017/3/11/medline KW - Diabetes KW - fermentation KW - glucose tolerance KW - insulin SP - 317 EP - 323 JF - Pharmaceutical biology JO - Pharm Biol VL - 55 IS - 1 N2 - CONTEXT: Red ginseng (heat-processed Panax ginseng) is a well-known alternative medicine with pharmacological antidiabetic activity. It exerts pharmacological effects through the transformation of saponin into metabolites by the intestinal microbiota. Given that intestinal conditions and intestinal microflora vary among individuals, the pharmacological effects of orally administered red ginseng likely may vary among individuals. OBJECTIVE: To overcome this variation and produce homogeneously effective red ginseng, we evaluated the antidiabetic effects of probiotic-fermented red ginseng in a mouse model. MATERIALS AND METHODS: The antidiabetic efficacy of orally administered probiotic-fermented red ginseng was assessed in ICR mice after induction of diabetes using streptozotocin (170 mg/kg body weight). Samples were given orally for 8 weeks, and indicators involved in diabetic disorders such as body weight change, water intake, blood glucose, glucose tolerance and various biochemical parameters were determined. RESULTS: Oral administration of probiotic-fermented red ginseng significantly decreased the level of blood glucose of about 62.5% in the fasting state and induced a significant increase in glucose tolerance of about 10.2% compared to the control diabetic mice. Additionally, various indicators of diabetes and biochemical data (e.g., blood glycosylated haemoglobin level, serum concentrations of insulin, and α-amylase activity) showed a significant improvement in the diabetic conditions of the mice treated with probiotic-fermented red ginseng in comparison with those of control diabetic mice. DISCUSSION AND CONCLUSION: Our results demonstrate the antidiabetic effects of probiotic-fermented red ginseng in the streptozotocin-induced mouse diabetes model and suggest that probiotic-fermented red ginseng may be a uniformly effective red ginseng product. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/27927080/Red_ginseng_powder_fermented_with_probiotics_exerts_antidiabetic_effects_in_the_streptozotocin_induced_mouse_diabetes_model_ L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2016.1237978 DB - PRIME DP - Unbound Medicine ER -