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Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica.
Pharm Biol. 2017 Dec; 55(1):324-329.PB

Abstract

CONTEXT

Stachys guyoniana Noë ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine.

OBJECTIVE

To investigate their antioxidant, anticholinesterase and antibacterial activities.

MATERIAL AND METHODS

n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and methanol (MEMA) and chloroform (CEMA) aerial part extracts of M. aquatica and methanol (MERMA) and acetone (AERMA) roots extracts of M. aquatica were evaluated for their antioxidant activity by the β-carotene-linoleic acid, DPPH• and ABTS•+ scavenging, CUPRAC and metal chelating assays. The anticholinesterase activity was tested against AChE and BChE. The antibacterial activity was assessed by MICs determination against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella heidelberg, Klebsiella pneumoniae, Enterobacter aerogenes and Morganella morganii strains.

RESULTS

In the β-carotene test, the CESG (IC50: 2.3 ± 1.27 μg/mL) exhibited the highest activity. The BESG was the best scavenger of DPPH• (IC50: 2.91 ± 0.14 μg/mL). In the ABTS test, AERMA was the most active (IC50: 4.21 ± 0.28 μg/mL). However, with the CUPRAC, the BESG exhibited the best activity (A0.50: 0.15 ± 0.05 μg/mL) and was active in metal chelating assay with 48% inhibition at 100 μg/mL. The BESG was the best AChE inhibitor (IC50: 5.78 ± 0.01 μg/mL) however, the AERMA showed the highest BChE inhibitory activity (IC50: 19.23 ± 1.42 μg/mL). The tested extracts exhibited a good antibacterial activity.

CONCLUSION

This study demonstrated good antioxidant, anticholinesterase and antibacterial potential of S. guyoniana and M. aquatica, which fits in well with their use in folk medicine.

Authors+Show Affiliations

a Département de chimie, Laboratoire d'Obtention de Substances Thérapeutiques (LOST) , Université des frères Mentouri-Constantine , Constantine , Algeria.b Faculty of Sciences, Department of Chemistry , Mugla Sıtkı Koçman University , Muğla , Turkey.a Département de chimie, Laboratoire d'Obtention de Substances Thérapeutiques (LOST) , Université des frères Mentouri-Constantine , Constantine , Algeria.b Faculty of Sciences, Department of Chemistry , Mugla Sıtkı Koçman University , Muğla , Turkey.a Département de chimie, Laboratoire d'Obtention de Substances Thérapeutiques (LOST) , Université des frères Mentouri-Constantine , Constantine , Algeria.b Faculty of Sciences, Department of Chemistry , Mugla Sıtkı Koçman University , Muğla , Turkey.a Département de chimie, Laboratoire d'Obtention de Substances Thérapeutiques (LOST) , Université des frères Mentouri-Constantine , Constantine , Algeria.a Département de chimie, Laboratoire d'Obtention de Substances Thérapeutiques (LOST) , Université des frères Mentouri-Constantine , Constantine , Algeria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27927090

Citation

Ferhat, Maria, et al. "Antioxidant, Anticholinesterase and Antibacterial Activities of Stachys Guyoniana and Mentha Aquatica." Pharmaceutical Biology, vol. 55, no. 1, 2017, pp. 324-329.
Ferhat M, Erol E, Beladjila KA, et al. Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica. Pharm Biol. 2017;55(1):324-329.
Ferhat, M., Erol, E., Beladjila, K. A., Çetintaş, Y., Duru, M. E., Öztürk, M., Kabouche, A., & Kabouche, Z. (2017). Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica. Pharmaceutical Biology, 55(1), 324-329.
Ferhat M, et al. Antioxidant, Anticholinesterase and Antibacterial Activities of Stachys Guyoniana and Mentha Aquatica. Pharm Biol. 2017;55(1):324-329. PubMed PMID: 27927090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica. AU - Ferhat,Maria, AU - Erol,Ebru, AU - Beladjila,Khadidja Aya, AU - Çetintaş,Yunus, AU - Duru,Mehmet Emin, AU - Öztürk,Mehmet, AU - Kabouche,Ahmed, AU - Kabouche,Zahia, PY - 2016/12/9/entrez PY - 2016/12/9/pubmed PY - 2017/3/10/medline KW - ABTS+ KW - CUPRAC KW - DPPH KW - agar dilution KW - cholinesterase inhibitory activity KW - metal chelating KW - β-carotene/linoleic acid SP - 324 EP - 329 JF - Pharmaceutical biology JO - Pharm Biol VL - 55 IS - 1 N2 - CONTEXT: Stachys guyoniana Noë ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine. OBJECTIVE: To investigate their antioxidant, anticholinesterase and antibacterial activities. MATERIAL AND METHODS: n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and methanol (MEMA) and chloroform (CEMA) aerial part extracts of M. aquatica and methanol (MERMA) and acetone (AERMA) roots extracts of M. aquatica were evaluated for their antioxidant activity by the β-carotene-linoleic acid, DPPH• and ABTS•+ scavenging, CUPRAC and metal chelating assays. The anticholinesterase activity was tested against AChE and BChE. The antibacterial activity was assessed by MICs determination against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella heidelberg, Klebsiella pneumoniae, Enterobacter aerogenes and Morganella morganii strains. RESULTS: In the β-carotene test, the CESG (IC50: 2.3 ± 1.27 μg/mL) exhibited the highest activity. The BESG was the best scavenger of DPPH• (IC50: 2.91 ± 0.14 μg/mL). In the ABTS test, AERMA was the most active (IC50: 4.21 ± 0.28 μg/mL). However, with the CUPRAC, the BESG exhibited the best activity (A0.50: 0.15 ± 0.05 μg/mL) and was active in metal chelating assay with 48% inhibition at 100 μg/mL. The BESG was the best AChE inhibitor (IC50: 5.78 ± 0.01 μg/mL) however, the AERMA showed the highest BChE inhibitory activity (IC50: 19.23 ± 1.42 μg/mL). The tested extracts exhibited a good antibacterial activity. CONCLUSION: This study demonstrated good antioxidant, anticholinesterase and antibacterial potential of S. guyoniana and M. aquatica, which fits in well with their use in folk medicine. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/27927090/Antioxidant_anticholinesterase_and_antibacterial_activities_of_Stachys_guyoniana_and_Mentha_aquatica_ L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2016.1238488 DB - PRIME DP - Unbound Medicine ER -