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Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies.

Abstract

BACKGROUND

Data on the longitudinal association of walking pace with the risk of cognitive decline and dementia are inconsistent and inconclusive. Therefore, researchers conducted a meta-analysis of prospective cohort studies to quantitatively assess the association of walking pace with the risk of cognitive decline and dementia among elderly populations.

METHODS

Eligible studies were searched in PubMed and EMBASE through April 22, 2016. Additional information was retrieved through Google Scholar or hand review of the reference lists from the relevant studies. Prospective cohort studies were included if they reported relative risk (RR) and the corresponding 95% confidence interval (CI) of cognitive decline or dementia in relation to walking pace.

RESULTS

Seventeen studies were identified, including 10 studies reporting the RR of cognitive decline (9,949 participants and 2,547 events) and 10 presenting the RR of dementia (14,140 participants and 1,903 events). Comparing the lowest to the highest category of walking pace, the pooled RR was 1.89 (95% CI = 1.54-2.31) for cognitive decline and 1.66 (95% CI = 1.43-1.92) for dementia. With every 1 dm/s (360 m/h) decrement in walking pace, the risk of dementia was increased by 13% (RR = 1.13; 95% CI = 1.08-1.18).

CONCLUSIONS

This meta-analysis provides accumulated evidence supporting that slow or decreased walking pace is significantly associated with elevated risk of cognitive decline and dementia in elderly populations.

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  • Authors+Show Affiliations

    ,

    Department of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China. Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.

    ,

    Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.

    ,

    Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.

    ,

    Department of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China.

    ,

    Department of Kinesiology and Nutrition, College of Applied Health Science, University of Illinois at Chicago.

    ,

    Department of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China.

    ,

    Department of Sport Rehabilitation, School of Kinesiology, Shanghai University of Sport, Shanghai, China. chenpeijie@sus.edu.cn kahe@indiana.edu.

    Department of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University.

    Source

    MeSH

    Aged
    Cognitive Dysfunction
    Cohort Studies
    Dementia
    Humans
    Prospective Studies
    Risk Assessment
    Walking Speed

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Research Support, Non-U.S. Gov't
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    27927757

    Citation

    Quan, Minghui, et al. "Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: a Meta-analysis of Prospective Cohort Studies." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 72, no. 2, 2017, pp. 266-270.
    Quan M, Xun P, Chen C, et al. Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies. J Gerontol A Biol Sci Med Sci. 2017;72(2):266-270.
    Quan, M., Xun, P., Chen, C., Wen, J., Wang, Y., Wang, R., ... He, K. (2017). Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 72(2), pp. 266-270. doi:10.1093/gerona/glw121.
    Quan M, et al. Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: a Meta-analysis of Prospective Cohort Studies. J Gerontol A Biol Sci Med Sci. 2017;72(2):266-270. PubMed PMID: 27927757.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Walking Pace and the Risk of Cognitive Decline and Dementia in Elderly Populations: A Meta-analysis of Prospective Cohort Studies. AU - Quan,Minghui, AU - Xun,Pengcheng, AU - Chen,Cheng, AU - Wen,Ju, AU - Wang,Yiyu, AU - Wang,Ru, AU - Chen,Peijie, AU - He,Ka, Y1 - 2016/12/07/ PY - 2016/02/17/received PY - 2016/06/07/accepted PY - 2016/12/9/pubmed PY - 2017/8/15/medline PY - 2016/12/9/entrez KW - Cognitive decline KW - Dementia KW - Walking pace KW - “Meta-analysis” SP - 266 EP - 270 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 72 IS - 2 N2 - BACKGROUND: Data on the longitudinal association of walking pace with the risk of cognitive decline and dementia are inconsistent and inconclusive. Therefore, researchers conducted a meta-analysis of prospective cohort studies to quantitatively assess the association of walking pace with the risk of cognitive decline and dementia among elderly populations. METHODS: Eligible studies were searched in PubMed and EMBASE through April 22, 2016. Additional information was retrieved through Google Scholar or hand review of the reference lists from the relevant studies. Prospective cohort studies were included if they reported relative risk (RR) and the corresponding 95% confidence interval (CI) of cognitive decline or dementia in relation to walking pace. RESULTS: Seventeen studies were identified, including 10 studies reporting the RR of cognitive decline (9,949 participants and 2,547 events) and 10 presenting the RR of dementia (14,140 participants and 1,903 events). Comparing the lowest to the highest category of walking pace, the pooled RR was 1.89 (95% CI = 1.54-2.31) for cognitive decline and 1.66 (95% CI = 1.43-1.92) for dementia. With every 1 dm/s (360 m/h) decrement in walking pace, the risk of dementia was increased by 13% (RR = 1.13; 95% CI = 1.08-1.18). CONCLUSIONS: This meta-analysis provides accumulated evidence supporting that slow or decreased walking pace is significantly associated with elevated risk of cognitive decline and dementia in elderly populations. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/27927757/Walking_Pace_and_the_Risk_of_Cognitive_Decline_and_Dementia_in_Elderly_Populations:_A_Meta_analysis_of_Prospective_Cohort_Studies_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glw121 DB - PRIME DP - Unbound Medicine ER -