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Association of allergy/immunology and obstructive sleep apnea.

Abstract

Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse that results in nonrefreshing sleep, excessive daytime sleepiness, and, ultimately, adverse consequences on quality of life, the cardiovascular system, and neurocognitive performance. OSA has traditionally been linked to body habitus (obesity and increased neck circumference), racial demographics, alcohol, tobacco, and sedative use. Numerous other conditions are linked to OSA, which may have clinical relevance. Specifically, asthma and nasal obstructive syndromes, e.g., rhinitis, have been shown to be risk factors. This review used the anatomic homogeneity of the upper and lower airways as an explanation for the inflammatory conditions that underlie and interrelate rhinitis, asthma, and OSA. There is strong evidence that both immunoglobulin Emediated and irritant-induced inflammation in either airway location play a significant role in all three (OSA, rhinitis, and asthma). We highlighted pathophysiologic, chemical, and cellular factors that explain the distinct relationship among OSA, asthma, and rhinitis, with emphasis for increased provider vigilance of the other syndromes when a patient is diagnosed with either entity.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Allergy-Immunology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

    ,

    Source

    Allergy and asthma proceedings 37:6 2016 Nov pg 443-449

    MeSH

    Comorbidity
    Humans
    Hypersensitivity
    Inflammation
    Risk Factors
    Sleep Apnea, Obstructive

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    27931299

    Citation

    Calais, Charles J., et al. "Association of Allergy/immunology and Obstructive Sleep Apnea." Allergy and Asthma Proceedings, vol. 37, no. 6, 2016, pp. 443-449.
    Calais CJ, Robertson BD, Beakes DE. Association of allergy/immunology and obstructive sleep apnea. Allergy Asthma Proc. 2016;37(6):443-449.
    Calais, C. J., Robertson, B. D., & Beakes, D. E. (2016). Association of allergy/immunology and obstructive sleep apnea. Allergy and Asthma Proceedings, 37(6), pp. 443-449.
    Calais CJ, Robertson BD, Beakes DE. Association of Allergy/immunology and Obstructive Sleep Apnea. Allergy Asthma Proc. 2016;37(6):443-449. PubMed PMID: 27931299.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of allergy/immunology and obstructive sleep apnea. AU - Calais,Charles J, AU - Robertson,Brian D, AU - Beakes,Douglas E, PY - 2016/12/10/entrez PY - 2016/12/10/pubmed PY - 2017/8/18/medline SP - 443 EP - 449 JF - Allergy and asthma proceedings JO - Allergy Asthma Proc VL - 37 IS - 6 N2 - Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse that results in nonrefreshing sleep, excessive daytime sleepiness, and, ultimately, adverse consequences on quality of life, the cardiovascular system, and neurocognitive performance. OSA has traditionally been linked to body habitus (obesity and increased neck circumference), racial demographics, alcohol, tobacco, and sedative use. Numerous other conditions are linked to OSA, which may have clinical relevance. Specifically, asthma and nasal obstructive syndromes, e.g., rhinitis, have been shown to be risk factors. This review used the anatomic homogeneity of the upper and lower airways as an explanation for the inflammatory conditions that underlie and interrelate rhinitis, asthma, and OSA. There is strong evidence that both immunoglobulin Emediated and irritant-induced inflammation in either airway location play a significant role in all three (OSA, rhinitis, and asthma). We highlighted pathophysiologic, chemical, and cellular factors that explain the distinct relationship among OSA, asthma, and rhinitis, with emphasis for increased provider vigilance of the other syndromes when a patient is diagnosed with either entity. SN - 1539-6304 UR - https://www.unboundmedicine.com/medline/citation/27931299/Association_of_allergy/immunology_and_obstructive_sleep_apnea L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1088-5412&volume=37&issue=6&spage=443&aulast=Calais DB - PRIME DP - Unbound Medicine ER -