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Sugar-Sweetened Beverage but Not Diet Soda Consumption Is Positively Associated with Progression of Insulin Resistance and Prediabetes.
J Nutr. 2016 Dec; 146(12):2544-2550.JN

Abstract

BACKGROUND

Previous studies have shown an inconsistent relation between habitual beverage consumption and insulin resistance and prediabetes.

OBJECTIVE

The objective of the present study was to test the hypothesis that the consumption of sugar-sweetened beverages (SSBs), rather than diet soda, is associated with long-term progression of insulin resistance and the development of prediabetes.

METHODS

We analyzed the prospective association between cumulative mean consumption of SSBs or diet soda and incident prediabetes (n = 1685) identified across a median of 14 y of follow-up in participants [mean ± SD age: 51.9 ± 9.2 y; 59.6% women; mean ± SD body mass index (BMI; kg/m2): 26.3 ± 4.4] of the Framingham Offspring cohort. The prospective association between beverage consumption and change in homeostasis model assessment of insulin resistance (HOMA-IR; n = 2076) over ∼7 y was also analyzed. The cumulative mean consumption of SSBs and diet soda was estimated by using food-frequency questionnaires. Multivariable Cox proportional hazards models and linear regression models were implemented to estimate the HRs of incident prediabetes and change in HOMA-IR, respectively.

RESULTS

After adjustment for multiple potential confounders, including baseline BMI, we observed that SSB intake was positively associated with incident prediabetes (P-trend < 0.001); the highest SSB consumers (>3 servings/wk; median: 6 servings/wk) had a 46% higher risk of developing prediabetes than did the SSB nonconsumers (HR: 1.46; 95% CI: 1.16, 1.83). Higher SSB intake was also associated with a greater increase in HOMA-IR (P-trend = 0.006). No prospective associations were observed between diet soda intake and risk of prediabetes (P-trend = 0.24) or changes in HOMA-IR (P-trend = 0.25). These associations were similar after additional adjustment for change in BMI.

CONCLUSION

Regular SSB intake, but not diet soda intake, is associated with a greater increase in insulin resistance and a higher risk of developing prediabetes in a group of middle-aged adults.

Authors+Show Affiliations

Nutritional Epidemiology Laboratory.Nutritional Epidemiology Laboratory.Division of General Internal Medicine, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA; and.Framingham Heart Study, Population Science Branch, National Heart, Lung, and Blood Institute, Framingham, MA.Nutritional Epidemiology Laboratory.Nutrition and Genomics Laboratory, and.Nutritional Epidemiology Laboratory.Energy Metabolism Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.Nutritional Epidemiology Laboratory, nicola.mckeown@tufts.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27934644

Citation

Ma, Jiantao, et al. "Sugar-Sweetened Beverage but Not Diet Soda Consumption Is Positively Associated With Progression of Insulin Resistance and Prediabetes." The Journal of Nutrition, vol. 146, no. 12, 2016, pp. 2544-2550.
Ma J, Jacques PF, Meigs JB, et al. Sugar-Sweetened Beverage but Not Diet Soda Consumption Is Positively Associated with Progression of Insulin Resistance and Prediabetes. J Nutr. 2016;146(12):2544-2550.
Ma, J., Jacques, P. F., Meigs, J. B., Fox, C. S., Rogers, G. T., Smith, C. E., Hruby, A., Saltzman, E., & McKeown, N. M. (2016). Sugar-Sweetened Beverage but Not Diet Soda Consumption Is Positively Associated with Progression of Insulin Resistance and Prediabetes. The Journal of Nutrition, 146(12), 2544-2550.
Ma J, et al. Sugar-Sweetened Beverage but Not Diet Soda Consumption Is Positively Associated With Progression of Insulin Resistance and Prediabetes. J Nutr. 2016;146(12):2544-2550. PubMed PMID: 27934644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sugar-Sweetened Beverage but Not Diet Soda Consumption Is Positively Associated with Progression of Insulin Resistance and Prediabetes. AU - Ma,Jiantao, AU - Jacques,Paul F, AU - Meigs,James B, AU - Fox,Caroline S, AU - Rogers,Gail T, AU - Smith,Caren E, AU - Hruby,Adela, AU - Saltzman,Edward, AU - McKeown,Nicola M, Y1 - 2016/11/09/ PY - 2016/04/11/received PY - 2016/05/06/revised PY - 2016/10/11/accepted PY - 2016/12/10/entrez PY - 2016/12/10/pubmed PY - 2017/6/7/medline KW - HOMA-IR KW - diet soda KW - insulin resistance KW - prediabetes KW - sugar-sweetened beverages SP - 2544 EP - 2550 JF - The Journal of nutrition JO - J Nutr VL - 146 IS - 12 N2 - BACKGROUND: Previous studies have shown an inconsistent relation between habitual beverage consumption and insulin resistance and prediabetes. OBJECTIVE: The objective of the present study was to test the hypothesis that the consumption of sugar-sweetened beverages (SSBs), rather than diet soda, is associated with long-term progression of insulin resistance and the development of prediabetes. METHODS: We analyzed the prospective association between cumulative mean consumption of SSBs or diet soda and incident prediabetes (n = 1685) identified across a median of 14 y of follow-up in participants [mean ± SD age: 51.9 ± 9.2 y; 59.6% women; mean ± SD body mass index (BMI; kg/m2): 26.3 ± 4.4] of the Framingham Offspring cohort. The prospective association between beverage consumption and change in homeostasis model assessment of insulin resistance (HOMA-IR; n = 2076) over ∼7 y was also analyzed. The cumulative mean consumption of SSBs and diet soda was estimated by using food-frequency questionnaires. Multivariable Cox proportional hazards models and linear regression models were implemented to estimate the HRs of incident prediabetes and change in HOMA-IR, respectively. RESULTS: After adjustment for multiple potential confounders, including baseline BMI, we observed that SSB intake was positively associated with incident prediabetes (P-trend < 0.001); the highest SSB consumers (>3 servings/wk; median: 6 servings/wk) had a 46% higher risk of developing prediabetes than did the SSB nonconsumers (HR: 1.46; 95% CI: 1.16, 1.83). Higher SSB intake was also associated with a greater increase in HOMA-IR (P-trend = 0.006). No prospective associations were observed between diet soda intake and risk of prediabetes (P-trend = 0.24) or changes in HOMA-IR (P-trend = 0.25). These associations were similar after additional adjustment for change in BMI. CONCLUSION: Regular SSB intake, but not diet soda intake, is associated with a greater increase in insulin resistance and a higher risk of developing prediabetes in a group of middle-aged adults. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/27934644/Sugar_Sweetened_Beverage_but_Not_Diet_Soda_Consumption_Is_Positively_Associated_with_Progression_of_Insulin_Resistance_and_Prediabetes_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.116.234047 DB - PRIME DP - Unbound Medicine ER -