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Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing.
PLoS One 2016; 11(12):e0166330Plos

Abstract

This paper demonstrates flexible and stretchable microneedle patches that combine soft and flexible base substrates with hard and sharp stainless steel microneedles. An elastomeric polymer base enables conformal contact between the microneedle patch and the complex topography and texture of the underlying skin, while robust and sharp stainless steel microneedles reliably pierce the outer layers of the skin. The flexible microneedle patches have been realized by magnetically assembling short stainless steel microneedles into a flexible polymer supporting base. In our experimental investigation, the microneedle patches were applied to human skin and an excellent adaptation of the patch to the wrinkles and deformations of the skin was verified, while at the same time the microneedles reliably penetrate the surface of the skin. The unobtrusive flexible and stretchable microneedle patches have great potential for transdermal biointerfacing in a variety of emerging applications such as transdermal drug delivery, bioelectric treatments and wearable bio-electronics for health and fitness monitoring.

Authors+Show Affiliations

KTH Royal Institute of Technology, School of Electrical Engineering, Department of Micro and Nanosystems, Stockholm, Sweden.KTH Royal Institute of Technology, School of Electrical Engineering, Department of Micro and Nanosystems, Stockholm, Sweden.KTH Royal Institute of Technology, School of Electrical Engineering, Department of Micro and Nanosystems, Stockholm, Sweden.KTH Royal Institute of Technology, School of Electrical Engineering, Department of Micro and Nanosystems, Stockholm, Sweden.KTH Royal Institute of Technology, School of Electrical Engineering, Department of Micro and Nanosystems, Stockholm, Sweden. Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology, Karlsruhe, Germany.KTH Royal Institute of Technology, School of Electrical Engineering, Department of Micro and Nanosystems, Stockholm, Sweden.KTH Royal Institute of Technology, School of Electrical Engineering, Department of Micro and Nanosystems, Stockholm, Sweden.KTH Royal Institute of Technology, School of Electrical Engineering, Department of Micro and Nanosystems, Stockholm, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27935976

Citation

Rajabi, Mina, et al. "Flexible and Stretchable Microneedle Patches With Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing." PloS One, vol. 11, no. 12, 2016, pp. e0166330.
Rajabi M, Roxhed N, Shafagh RZ, et al. Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing. PLoS ONE. 2016;11(12):e0166330.
Rajabi, M., Roxhed, N., Shafagh, R. Z., Haraldson, T., Fischer, A. C., Wijngaart, W. V., ... Niklaus, F. (2016). Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing. PloS One, 11(12), pp. e0166330. doi:10.1371/journal.pone.0166330.
Rajabi M, et al. Flexible and Stretchable Microneedle Patches With Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing. PLoS ONE. 2016;11(12):e0166330. PubMed PMID: 27935976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing. AU - Rajabi,Mina, AU - Roxhed,Niclas, AU - Shafagh,Reza Zandi, AU - Haraldson,Tommy, AU - Fischer,Andreas Christin, AU - Wijngaart,Wouter van der, AU - Stemme,Göran, AU - Niklaus,Frank, Y1 - 2016/12/09/ PY - 2016/07/27/received PY - 2016/10/26/accepted PY - 2016/12/10/entrez PY - 2016/12/10/pubmed PY - 2017/7/15/medline SP - e0166330 EP - e0166330 JF - PloS one JO - PLoS ONE VL - 11 IS - 12 N2 - This paper demonstrates flexible and stretchable microneedle patches that combine soft and flexible base substrates with hard and sharp stainless steel microneedles. An elastomeric polymer base enables conformal contact between the microneedle patch and the complex topography and texture of the underlying skin, while robust and sharp stainless steel microneedles reliably pierce the outer layers of the skin. The flexible microneedle patches have been realized by magnetically assembling short stainless steel microneedles into a flexible polymer supporting base. In our experimental investigation, the microneedle patches were applied to human skin and an excellent adaptation of the patch to the wrinkles and deformations of the skin was verified, while at the same time the microneedles reliably penetrate the surface of the skin. The unobtrusive flexible and stretchable microneedle patches have great potential for transdermal biointerfacing in a variety of emerging applications such as transdermal drug delivery, bioelectric treatments and wearable bio-electronics for health and fitness monitoring. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/27935976/Flexible_and_Stretchable_Microneedle_Patches_with_Integrated_Rigid_Stainless_Steel_Microneedles_for_Transdermal_Biointerfacing_ L2 - http://dx.plos.org/10.1371/journal.pone.0166330 DB - PRIME DP - Unbound Medicine ER -