Abstract
In this study, a method is presented that can be used to generate full out-of-die compressibility and compactibility profiles using the data from only 2 tablets. For each material, one tablet was compacted at the maximum pressure of interest and a second tablet at a relatively low pressure. The in-die data collected during compaction to the maximum pressure of interest and the solid fraction change after ejection for both tablets were used to generate a profile equivalent to a complete out-of-die compressibility profile. After measuring the tensile strengths of each tablet, a compactibility profile was produced by fitting the out-of-die porosity and tensile strength data to the Ryshkewitch-Duckworth equation. This method generated accurate out-of-die compressibility and compactibility profiles for each of the materials studied. Not only is this technique computationally simple, but in cases where only small amounts of raw material are available, this method allows a detailed understanding of a material's mechanical behavior to be assessed.
TY - JOUR
T1 - Full Out-of-Die Compressibility and Compactibility Profiles From Two Tablets.
AU - Katz,Jeffrey M,
AU - Buckner,Ira S,
Y1 - 2016/12/06/
PY - 2016/09/28/received
PY - 2016/11/07/revised
PY - 2016/11/08/accepted
PY - 2016/12/13/pubmed
PY - 2017/12/5/medline
PY - 2016/12/13/entrez
KW - compaction
KW - compression
KW - mechanical properties
KW - powder technology
KW - tablet
KW - tableting
SP - 843
EP - 849
JF - Journal of pharmaceutical sciences
JO - J Pharm Sci
VL - 106
IS - 3
N2 - In this study, a method is presented that can be used to generate full out-of-die compressibility and compactibility profiles using the data from only 2 tablets. For each material, one tablet was compacted at the maximum pressure of interest and a second tablet at a relatively low pressure. The in-die data collected during compaction to the maximum pressure of interest and the solid fraction change after ejection for both tablets were used to generate a profile equivalent to a complete out-of-die compressibility profile. After measuring the tensile strengths of each tablet, a compactibility profile was produced by fitting the out-of-die porosity and tensile strength data to the Ryshkewitch-Duckworth equation. This method generated accurate out-of-die compressibility and compactibility profiles for each of the materials studied. Not only is this technique computationally simple, but in cases where only small amounts of raw material are available, this method allows a detailed understanding of a material's mechanical behavior to be assessed.
SN - 1520-6017
UR - https://www.unboundmedicine.com/medline/citation/27938894/Full_Out_of_Die_Compressibility_and_Compactibility_Profiles_From_Two_Tablets_
DB - PRIME
DP - Unbound Medicine
ER -
