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Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa.
J Adolesc Health. 2017 Feb; 60(2):229-232.JA

Abstract

PURPOSE

We examined the relationships between malnutrition, lifestyle factors, and bone health in anorexia nervosa (AN) via dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT).

METHODS

Seventy adolescent girls with AN and 132 normal-weighted controls underwent pQCT tibial measures including trabecular volumetric bone mineral density (vBMD), cortical vBMD, and cortical thickness. Participants with AN underwent DXA measures of the axial skeleton. We assessed the association of DXA and pQCT measures with clinical and lifestyle variables.

RESULTS

Body mass index Z-score and ideal body weight percentage were positively correlated with trabecular vBMD, cortical CSA, and section modulus (p < .04). Exercise was associated with all pQCT measures but only with hip BMD by DXA. In AN, the use of antidepressants was associated with lower pQCT measures (p < .03).

CONCLUSIONS

Antidepressants may negatively, and exercise positively, influence BMD in adolescents with eating disorders. These findings offer a provocative look at two longstanding questions.

Authors+Show Affiliations

Division of Adolescent Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Division of Gynecology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: amy.divasta@childrens.harvard.edu.Clinical Research Program, Boston Children's Hospital, Boston, Massachusetts; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts.Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.Division of Pediatric Nephrology, Stanford University School of Medicine, Palo Alto, California.Division of Pediatric Nephrology, Stanford University School of Medicine, Palo Alto, California.Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27939877

Citation

DiVasta, Amy D., et al. "Effect of Exercise and Antidepressants On Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa." The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, vol. 60, no. 2, 2017, pp. 229-232.
DiVasta AD, Feldman HA, O'Donnell JM, et al. Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa. J Adolesc Health. 2017;60(2):229-232.
DiVasta, A. D., Feldman, H. A., O'Donnell, J. M., Long, J., Leonard, M. B., & Gordon, C. M. (2017). Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa. The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 60(2), 229-232. https://doi.org/10.1016/j.jadohealth.2016.10.003
DiVasta AD, et al. Effect of Exercise and Antidepressants On Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa. J Adolesc Health. 2017;60(2):229-232. PubMed PMID: 27939877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa. AU - DiVasta,Amy D, AU - Feldman,Henry A, AU - O'Donnell,Jennifer M, AU - Long,Jin, AU - Leonard,Mary B, AU - Gordon,Catherine M, Y1 - 2016/12/06/ PY - 2016/07/21/received PY - 2016/10/07/revised PY - 2016/10/07/accepted PY - 2016/12/13/pubmed PY - 2017/11/29/medline PY - 2016/12/13/entrez KW - Anorexia nervosa KW - Antidepressant KW - DXA KW - Exercise KW - Malnutrition KW - Peripheral quantitative computed tomography SP - 229 EP - 232 JF - The Journal of adolescent health : official publication of the Society for Adolescent Medicine JO - J Adolesc Health VL - 60 IS - 2 N2 - PURPOSE: We examined the relationships between malnutrition, lifestyle factors, and bone health in anorexia nervosa (AN) via dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). METHODS: Seventy adolescent girls with AN and 132 normal-weighted controls underwent pQCT tibial measures including trabecular volumetric bone mineral density (vBMD), cortical vBMD, and cortical thickness. Participants with AN underwent DXA measures of the axial skeleton. We assessed the association of DXA and pQCT measures with clinical and lifestyle variables. RESULTS: Body mass index Z-score and ideal body weight percentage were positively correlated with trabecular vBMD, cortical CSA, and section modulus (p < .04). Exercise was associated with all pQCT measures but only with hip BMD by DXA. In AN, the use of antidepressants was associated with lower pQCT measures (p < .03). CONCLUSIONS: Antidepressants may negatively, and exercise positively, influence BMD in adolescents with eating disorders. These findings offer a provocative look at two longstanding questions. SN - 1879-1972 UR - https://www.unboundmedicine.com/medline/citation/27939877/Effect_of_Exercise_and_Antidepressants_on_Skeletal_Outcomes_in_Adolescent_Girls_With_Anorexia_Nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1054-139X(16)30380-9 DB - PRIME DP - Unbound Medicine ER -