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M1 muscarinic receptors are necessary for retrieval of remote context fear memory.
Physiol Behav. 2017 02 01; 169:202-207.PB

Abstract

Several studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully understood. Some evidences suggest that the central cholinergic system appears be involved in the modulation of these processes. Therefore, the present study aimed to investigate the effects of a pre-test administration of dicyclomine, a high-affinity M1 muscarinic receptor antagonist, on the retrieval of remote memories in fear conditioning and IA tasks. Male Wistar rats were trained, and after 1 or 28days, the rats received dicyclomine (16 or 32mg/kg, intraperitoneally, i.p.) and were tested in CFC, tone fear conditioning (TFC) and IA tasks. At both time intervals, 32mg/kg dicyclomine induced impairment of CFC. In TFC task only the performance of the rats 28days after training was impaired. The IA task was not affected in any of the studied intervals. These findings suggest a differential contribution of muscarinic receptors on recent and remote memories retrieval revealing a more generalized role in remote memory.

Authors+Show Affiliations

Departamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil.Departamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil. Electronic address: julianacarlota@gmail.com.Departamento de Psicobiologia, Universidade Federal de São Paulo - UNIFESP, São Paulo, SP, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27940145

Citation

Patricio, Rafael Rodisanski, et al. "M1 Muscarinic Receptors Are Necessary for Retrieval of Remote Context Fear Memory." Physiology & Behavior, vol. 169, 2017, pp. 202-207.
Patricio RR, Soares JC, Oliveira MG. M1 muscarinic receptors are necessary for retrieval of remote context fear memory. Physiol Behav. 2017;169:202-207.
Patricio, R. R., Soares, J. C., & Oliveira, M. G. (2017). M1 muscarinic receptors are necessary for retrieval of remote context fear memory. Physiology & Behavior, 169, 202-207. https://doi.org/10.1016/j.physbeh.2016.12.008
Patricio RR, Soares JC, Oliveira MG. M1 Muscarinic Receptors Are Necessary for Retrieval of Remote Context Fear Memory. Physiol Behav. 2017 02 1;169:202-207. PubMed PMID: 27940145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - M1 muscarinic receptors are necessary for retrieval of remote context fear memory. AU - Patricio,Rafael Rodisanski, AU - Soares,Juliana Carlota Kramer, AU - Oliveira,Maria Gabriela Menezes, Y1 - 2016/12/07/ PY - 2016/08/04/received PY - 2016/10/17/revised PY - 2016/12/02/accepted PY - 2016/12/13/pubmed PY - 2017/6/29/medline PY - 2016/12/13/entrez KW - Acetylcholine KW - Fear conditioning KW - Inhibitory avoidance KW - M1 receptor KW - Memory retrieval KW - Remote memory SP - 202 EP - 207 JF - Physiology & behavior JO - Physiol Behav VL - 169 N2 - Several studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully understood. Some evidences suggest that the central cholinergic system appears be involved in the modulation of these processes. Therefore, the present study aimed to investigate the effects of a pre-test administration of dicyclomine, a high-affinity M1 muscarinic receptor antagonist, on the retrieval of remote memories in fear conditioning and IA tasks. Male Wistar rats were trained, and after 1 or 28days, the rats received dicyclomine (16 or 32mg/kg, intraperitoneally, i.p.) and were tested in CFC, tone fear conditioning (TFC) and IA tasks. At both time intervals, 32mg/kg dicyclomine induced impairment of CFC. In TFC task only the performance of the rats 28days after training was impaired. The IA task was not affected in any of the studied intervals. These findings suggest a differential contribution of muscarinic receptors on recent and remote memories retrieval revealing a more generalized role in remote memory. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/27940145/M1_muscarinic_receptors_are_necessary_for_retrieval_of_remote_context_fear_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(16)30621-7 DB - PRIME DP - Unbound Medicine ER -