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A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications.
Pharm Biol 2017; 55(1):620-635PB

Abstract

CONTEXT

Radix Bupleuri has been used in traditional Chinese medicine for over 2000 years with functions of relieving exterior syndrome, clearing heat, regulating liver-qi, and lifting yang-qi. More natural active compounds, especially saikosaponins, have been isolated from Radix Bupleuri, which possess various valuable pharmacological activities.

OBJECTIVE

To summarize the current knowledge on pharmacological activities, mechanisms and applications of extracts and saikosaponins isolated from Radix Bupleuri, and obtain new insights for further research and development of Radix Bupleuri.

METHODS

PubMed, Web of Science, Science Direct, Research Gate, Academic Journals and Google Scholar were used as information sources through the inclusion of the search terms 'Radix Bupleuri', 'Bupleurum', 'saikosaponins', 'Radix Bupleuri preparation', and their combinations, mainly from the year 2008 to 2016 without language restriction. Clinical preparations containing Radix Bupleuri were collected from official website of China Food and Drug Administration (CFDA).

RESULTS AND CONCLUSION

296 papers were searched and 128 papers were reviewed. A broad spectrum of in vitro and in vivo research has proved that Radix Bupleuri extracts, saikosaponin a, saikosaponin d, saikosaponin c, and saikosaponin b2, exhibit evident anti-inflammatory, antitumor, antiviral, anti-allergic, immunoregulation, and neuroregulation activities mainly through NF-κB, MAPK or other pathways. 15 clinical preparations approved by CFDA remarkably broaden the application of Radix Bupleuri. The main side effect of Radix Bupleuri is liver damage when the dosage is excess, which indicates that the maximum tolerated dose is critical for clinical use of Radix Bupleuri extract and purified compounds.

Authors+Show Affiliations

a School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing , China.a School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing , China.a School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing , China.a School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing , China.a School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing , China.a School of Chinese Pharmacy , Beijing University of Chinese Medicine , Beijing , China.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

27951737

Citation

Yuan, Bochuan, et al. "A Systematic Review of the Active Saikosaponins and Extracts Isolated From Radix Bupleuri and Their Applications." Pharmaceutical Biology, vol. 55, no. 1, 2017, pp. 620-635.
Yuan B, Yang R, Ma Y, et al. A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications. Pharm Biol. 2017;55(1):620-635.
Yuan, B., Yang, R., Ma, Y., Zhou, S., Zhang, X., & Liu, Y. (2017). A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications. Pharmaceutical Biology, 55(1), pp. 620-635.
Yuan B, et al. A Systematic Review of the Active Saikosaponins and Extracts Isolated From Radix Bupleuri and Their Applications. Pharm Biol. 2017;55(1):620-635. PubMed PMID: 27951737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications. AU - Yuan,Bochuan, AU - Yang,Rui, AU - Ma,Yongsheng, AU - Zhou,Shan, AU - Zhang,Xiaodong, AU - Liu,Ying, PY - 2016/12/14/entrez PY - 2016/12/14/pubmed PY - 2017/3/14/medline KW - Radix Bupleuri KW - anti-inflammatory KW - antitumor KW - neuroregulation KW - saikosaponins SP - 620 EP - 635 JF - Pharmaceutical biology JO - Pharm Biol VL - 55 IS - 1 N2 - CONTEXT: Radix Bupleuri has been used in traditional Chinese medicine for over 2000 years with functions of relieving exterior syndrome, clearing heat, regulating liver-qi, and lifting yang-qi. More natural active compounds, especially saikosaponins, have been isolated from Radix Bupleuri, which possess various valuable pharmacological activities. OBJECTIVE: To summarize the current knowledge on pharmacological activities, mechanisms and applications of extracts and saikosaponins isolated from Radix Bupleuri, and obtain new insights for further research and development of Radix Bupleuri. METHODS: PubMed, Web of Science, Science Direct, Research Gate, Academic Journals and Google Scholar were used as information sources through the inclusion of the search terms 'Radix Bupleuri', 'Bupleurum', 'saikosaponins', 'Radix Bupleuri preparation', and their combinations, mainly from the year 2008 to 2016 without language restriction. Clinical preparations containing Radix Bupleuri were collected from official website of China Food and Drug Administration (CFDA). RESULTS AND CONCLUSION: 296 papers were searched and 128 papers were reviewed. A broad spectrum of in vitro and in vivo research has proved that Radix Bupleuri extracts, saikosaponin a, saikosaponin d, saikosaponin c, and saikosaponin b2, exhibit evident anti-inflammatory, antitumor, antiviral, anti-allergic, immunoregulation, and neuroregulation activities mainly through NF-κB, MAPK or other pathways. 15 clinical preparations approved by CFDA remarkably broaden the application of Radix Bupleuri. The main side effect of Radix Bupleuri is liver damage when the dosage is excess, which indicates that the maximum tolerated dose is critical for clinical use of Radix Bupleuri extract and purified compounds. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/27951737/A_systematic_review_of_the_active_saikosaponins_and_extracts_isolated_from_Radix_Bupleuri_and_their_applications_ L2 - http://www.tandfonline.com/doi/full/10.1080/13880209.2016.1262433 DB - PRIME DP - Unbound Medicine ER -