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Potential of probiotics in hypercholesterolemia: A meta-analysis.
Indian J Public Health 2016 Oct-Dec; 60(4):280-286IJ

Abstract

Human studies on the effects of probiotics on lowering blood cholesterol levels have not yielded conclusive results. A meta-analysis of randomized controlled trials evaluating the effect of probiotics on lipid profile was conducted. Articles were reviewed systematically from web search bases; PubMed, Cochrane Clinical Trial Registry. Those studies which were meeting the inclusion criteria-providing matching placebo, at least single blind for probiotics and placebo, providing mean and standard deviations and not involving the use of probiotics were selected. 14 studies from 12 randomized controlled trials were analyzed providing information of 606 normo/hypercholesterolemic patients using Review Manager 5.3 (The Cochrane Collaboration, Oxford, UK). The pooled mean net change for total cholesterol (TC) is -8.40 mg/dl (-13.63, -3.61), for low-density lipoprotein (LDL) is -6.63 mg/dl (-10.63, -2.63), for high-density-lipoprotein-cholesterol is 0.59 mg/dl (-0.92, 2.09), and for triglycerides is -1.32 mg/dl (-6.49, 3.85). The findings of the analysis conclude that probiotics supplementation does lower serum TC and LDL-cholesterol levels significantly and hence a reduction in the risk factor of developing coronary heart disease.

Authors+Show Affiliations

Senior Research Fellow, Food and Nutrition, Department of Home Science, University of Delhi, New Delhi, India.Professor and Head, Department of Physiology, St. John's Medical College, Bengaluru, Karnataka, India.Associate Professor, Department of Nutrition, Institute of Home Economics, University of Delhi, New Delhi, India.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

27976649

Citation

Sharma, Smriti, et al. "Potential of Probiotics in Hypercholesterolemia: a Meta-analysis." Indian Journal of Public Health, vol. 60, no. 4, 2016, pp. 280-286.
Sharma S, Kurpad AV, Puri S. Potential of probiotics in hypercholesterolemia: A meta-analysis. Indian J Public Health. 2016;60(4):280-286.
Sharma, S., Kurpad, A. V., & Puri, S. (2016). Potential of probiotics in hypercholesterolemia: A meta-analysis. Indian Journal of Public Health, 60(4), pp. 280-286. doi:10.4103/0019-557X.195859.
Sharma S, Kurpad AV, Puri S. Potential of Probiotics in Hypercholesterolemia: a Meta-analysis. Indian J Public Health. 2016;60(4):280-286. PubMed PMID: 27976649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential of probiotics in hypercholesterolemia: A meta-analysis. AU - Sharma,Smriti, AU - Kurpad,Anura V, AU - Puri,Seema, PY - 2016/12/16/entrez PY - 2016/12/16/pubmed PY - 2019/3/20/medline SP - 280 EP - 286 JF - Indian journal of public health JO - Indian J Public Health VL - 60 IS - 4 N2 - Human studies on the effects of probiotics on lowering blood cholesterol levels have not yielded conclusive results. A meta-analysis of randomized controlled trials evaluating the effect of probiotics on lipid profile was conducted. Articles were reviewed systematically from web search bases; PubMed, Cochrane Clinical Trial Registry. Those studies which were meeting the inclusion criteria-providing matching placebo, at least single blind for probiotics and placebo, providing mean and standard deviations and not involving the use of probiotics were selected. 14 studies from 12 randomized controlled trials were analyzed providing information of 606 normo/hypercholesterolemic patients using Review Manager 5.3 (The Cochrane Collaboration, Oxford, UK). The pooled mean net change for total cholesterol (TC) is -8.40 mg/dl (-13.63, -3.61), for low-density lipoprotein (LDL) is -6.63 mg/dl (-10.63, -2.63), for high-density-lipoprotein-cholesterol is 0.59 mg/dl (-0.92, 2.09), and for triglycerides is -1.32 mg/dl (-6.49, 3.85). The findings of the analysis conclude that probiotics supplementation does lower serum TC and LDL-cholesterol levels significantly and hence a reduction in the risk factor of developing coronary heart disease. SN - 0019-557X UR - https://www.unboundmedicine.com/medline/citation/27976649/Potential_of_probiotics_in_hypercholesterolemia:_A_meta_analysis_ L2 - http://www.ijph.in/article.asp?issn=0019-557X;year=2016;volume=60;issue=4;spage=280;epage=286;aulast=Sharma;type=2 DB - PRIME DP - Unbound Medicine ER -